Lowering of Sensory, Motor, and Pain-Tolerance Thresholds With Burst Duration Using Kilohertz-Frequency Alternating Current Electric Stimulation

Ward, Alexandra M.; Lucas-Toumbourou, Stacey

doi:10.1016/j.apmr.2007.04.009

Cited by 36 publications

(23 citation statements)

References 10 publications

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“…It also causes an increase in the frequency range capacity of the random frequency stimulation. Results from both the empirical data [37,51,52] and the simulation [our unpublished simulation result], support the idea of stimulation in the lower cycles, by increasing of the neuron diameters in the pain, motor, and sensory neurons. this could be extended as a rule that: for thinner neurons, the stimulation threshold is increased [51].…”

Section: It Is Well Known That There Is An Inverse Correlation Betweesupporting

confidence: 57%

“…Due to the existence of an asymmetry in the closing and opening dynamics of channels, for an open channel, by removing the external field or even applying the inverse one, these channels will not be closed (by the same opening mechanism). Hence if the field amplitude and the frequency are high enough [51,52] so that the summation phenomena occur [37,48,49], after certain periods, the induced membrane fields reach the threshold and initiate an action potential, ( Figure 5). This onset response, both in-vitro [37,48,51,52] and in-silico [53,54,80,81] have been well characterized.…”

Section: The First Stagementioning

confidence: 99%

“…Our data and other experimental data [1,[73][74][75][76][77][78][79]90] show the positive effects of increasing frequency for the reduction of the injected charge amplitude, achieving a proper stimulation of neurons. In addition, experimental evidence [37,51,52] show that the type of the axon (neuron) could affect the stimulation threshold, as will be discussed in more detail in the following section.…”

Section: The First Stagementioning

confidence: 99%

“…switching stimulation off and on periodically in the natural frequency of neurons, is the basic principle of the stimulation at ultrahigh frequencies. Figure 6 which was adapted from the references [51,52], shows the dependency of recovery time to stimulation amplitudes. It is worthy to note that in the low amplitude stimulation, the recovery time is more a function of the size and type of excitable neurons [56].…”

Section: Recovery Time Depends On the Inherent Properties Of Stimulatmentioning

confidence: 99%

“…Ultra high frequency has been mainly used for three cases: nerve conduction blocking, radiofrequency nerve ablation (and heating), and nerve stimulation. In the nerve conduction blocking, which used for example in chronic pain treatment [36,37,[51][52][53][54], stimulation signal in the kHz-frequency (1-100 KHz) is continuously applied to the tissue. This stimulation prevents signal transmission through the nerve, by blocking axons conduction [36].…”

Section: Introductionmentioning

confidence: 99%

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A new method of brain stimulation at ultra-high frequency

Jamali

Golshani

2019

Preprint

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Nerve stimulation via micro-electrode implants is one of the neurostimulation approaches which is used frequently in the medical treatment of some brain disorders, neural prosthetics, brainmachine interfaces and also in the cyborg. In this method, the electrical stimulation signal can be categorized by the frequency band: low frequency, high frequency, and ultra-high frequency. The stimulation should be less destructive, more smooth, and controllable. In this article, we present a brief description of the mechanism underlying the ultra-high frequency stimulation. In the flowing, from an informatics perspective, we propose a state-of-the-art, low destructive, and highly efficient stimulation method at the low amplitude ultra-high frequency signal. In this method, we have tried to reduce the adaptation of the nerve system by modulating the stimulation signal via a low frequency rectangular random wave. By this method, we could reach the "almost zero discharge" with minimum destructive effect in the experimental test on the fish nervous system.

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