Lowering Serum Urate With <scp>Urate‐Lowering</scp> Therapy to Target and Incident Fracture Among People With Gout

Wei, Jie; Choi, Hyon K.; Dalbeth, Nicola; Lane, Nancy E.; Wu, Jian; Lyu, Houchen; Zeng, Chao; Lei, Guanghua; Zhang, Yuqing

doi:10.1002/art.42504

Cited by 7 publications

(3 citation statements)

References 51 publications

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“…That said, gout is associated with a moderately higher risk of fracture [40,154], and postmenopausal females have elevated risk of osteoporotic fracture. A recent study indicated that ULT that achieves the serum urate target reduces the risk of fracture in gout patients [155]. Therefore, postmenopausal gout patients with osteoporosis might benefit from treat-to-target ULT.…”

Section: Treatment Responses In Females With Goutmentioning

confidence: 99%

The Evolving Landscape of Gout in the Female: A Narrative Review

Lee,

Sumpter,

Merriman

et al. 2023

GUCDD

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Gout is at least three times more prevalent in males than in females. However, concurrent with rising total gout prevalence, complex factors, including comorbidities, diet, lifestyle, and aging, have promoted higher gout prevalence in females. This narrative review focuses on summarizing recent developments in the landscape of gout in females and the mechanisms involved. New knowledge on sex hormone effects on both urate-excreting and urate-reabsorbing transporters and higher hypertension and chronic kidney disease prevalence in females compared to males may help explain why gout incidence rises robustly after menopause in females, to approach that in males. Racial and ethnic factors, risk profiles based on heritable genetic polymorphisms of urate transporters, diet, body mass index, and lifestyle factors differ according to sex. In addition, sex differences in clinical phenotypes, outcomes of gout, and non-gout illnesses include more frequent comorbidities, more pain and disability during gout flares, different perceptions of disease burden, and more frequent severe cutaneous hypersensitivity reaction to allopurinol in females. Collectively, such findings support the potential clinical benefits of tailoring gout and hyperuricemia treatment according to sex.

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Section: Treatment Responses In Females With Goutmentioning

confidence: 99%

The Evolving Landscape of Gout in the Female: A Narrative Review

Lee,

Sumpter,

Merriman

et al. 2023

GUCDD

View full text Add to dashboard Cite

show abstract

“…In an organism, uric acid is the final metabolite produced by the degradation of purine compounds by the liver. A delicate dynamic balance is maintained through production and excretion. , Once the balance is disturbed, it can lead to a variety of diseases, such as hyperuricemia, gout, , and cardiovascular system diseases. , As the most abundant catecholamine neurotransmitter in the brain, dopamine regulates the central nervous system. The abnormal concentration of dopamine can cause neurological disorders such as Parkinson’s disease, , schizophrenia, and Tourette’s syndrome …”

Section: Introductionmentioning

confidence: 99%

“…A delicate dynamic balance is maintained through production and excretion. 1,2 Once the balance is disturbed, it can lead to a variety of diseases, such as hyperuricemia, 3 gout, 4,5 and cardiovascular system diseases. 6,7 As the most abundant catecholamine neurotransmitter in the brain, dopamine regulates the central nervous system.…”

Section: Introductionmentioning

confidence: 99%

Co Single-Atom Nanozymes for the Simultaneous Electrochemical Detection of Uric Acid and Dopamine in Biofluids

Liu,

Zhang,

Wang

et al. 2024

ACS Appl. Nano Mater.

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The development of enzyme-like electrochemical sensors with atomic-level catalytic activity sites is essential for the accurate and sensitive detection of active molecules in biological fluids. In this study, a sensitive signal amplification platform for simultaneous analysis of dopamine (DA) and uric acid (UA) was prepared on a screen-printed carbon electrode (SPCE). The sensing platform combines polypyrrole (Ppy) with high electrical conductivity and cobalt single-atom nanozymes of tubular bisparaben nitrogen-carbon (Co-NNC) with excellent strong oxidase activity, named Ppy-Co-NNC/SPCE. The single-atom catalytic process and detection mechanism were investigated by using density functional theory. DA and UA were simultaneously detected in the ranges of 1−50 and 2−500 μM with detection limits as low as 0.025 and 0.411 μM, respectively. In addition, real-time detection of uric acid in sweat under resting and exercising conditions was achieved using a poly(vinyl alcohol) hydrogel as a sweat collector in combination with Ppy-Co-NNC/SPCE. Moreover, the simultaneous detection of UA and DA in human urine was also achieved. The method provides a new strategy for the detection of small molecules in biofluids, which is promising for sensing and personalized medicine.

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Lowering serum urate level to a guideline‐based target is associated with a lower risk of incident fracture in people with gout: comment on the article by Wei et al

Wang

Zhuo

Dong

et al. 2023

Arthritis & Rheumatology

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Lowering Serum Urate With Urate‐Lowering Therapy to Target and Incident Fracture Among People With Gout

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 7 publications

References 51 publications

The Evolving Landscape of Gout in the Female: A Narrative Review

The Evolving Landscape of Gout in the Female: A Narrative Review

Co Single-Atom Nanozymes for the Simultaneous Electrochemical Detection of Uric Acid and Dopamine in Biofluids

Lowering serum urate level to a guideline‐based target is associated with a lower risk of incident fracture in people with gout: comment on the article by Wei et al

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