Lowering the linoleic acid to alpha-linoleic acid ratio decreases the production of inflammatory mediators by cultured human endothelial cells

Bork, Christian Sørensen; Baker, Ella J.; Lundbye‐Christensen, Søren; Miles, Elizabeth A.; Calder, Philip C.

doi:10.1016/j.plefa.2018.12.001

Cited by 16 publications

(16 citation statements)

References 31 publications

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“…Shen et al [37] described no changes in IL-6 production after treatment of HUVECs with ALA at 50 and 200 µM followed by stimulation with lipopolysaccharide. In contrast, Bork et al [38] described reduced secretion of ICAM-1 after treatment of EA.hy926 cells with ALA at 100 µM. The current study did not explore the effects of FAs at this concentration since there was evidence of toxicity.…”

Section: Discussionmentioning

confidence: 58%

“…The functionality of plant n-3 PUFAs has been underexplored, this study examines the potential of plant-derived n-3 PUFAs as sustainable alternative sources to marine derived n-3 PUFAs with respect to modulation of inflammatory processes. A number of studies have examined the actions of EPA and DHA on EC inflammation and function [25-28, 30, 34-36], whereas only few have described effects of ALA [37][38][39][40] and none have described the effects of SDA in this context. There is no previous research which has compared the functions of marine derived n-3 PUFAs to those of plant derived n-3 PUFAs in ECs.…”

Section: Discussionmentioning

confidence: 99%

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Comparative anti-inflammatory effects of plant- and marine-derived omega-3 fatty acids explored in an endothelial cell line

Baker

Valenzuela

Souza

et al. 2020

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Comparative anti-inflammatory effects of plant- and marine-derived omega-3 fatty acids explored in an endothelial cell line

Baker

Valenzuela

Souza

et al. 2020

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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“…It is known that high amounts of oleic acid are important due to lowering of cholesterol and triglycerides, and these effects are helpful in preventing cancer, cardiovascular diseases, and autoimmune disorders [51]. Linoleic acid, the second main unsaturated fatty acid, is usually thought to suppress immune responses, and it may have benefits for asthma and inflammation [52,53]. As expected, the content of these two unsaturated fatty acids of C. oleifera oil were relatively high, which was consistent with the result of Li et al (2011) [54].…”

Section: Most Enzymes In C Oleifera Are Key Proteins Involved In Fatmentioning

confidence: 99%

Complementary transcriptome and proteome profiling in the mature seeds of Camellia oleifera from Hainan Island

Muhammad

et al. 2020

PLoS ONE

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Camellia oleifera Abel. (C. oleifera), as an important woody tree species producing edible oils in China, has attracted enormous attention due to its abundant unsaturated fatty acids and their associated benefits to human health. To reveal novel insights into the characters during the maturation period of this plant as well as the molecular basis of fatty acid biosynthesis and degradation, we conducted a conjoint analysis of the transcriptome and proteome of C. oleifera seeds from Hainan Island. Using RNA sequencing (RNA-seq) technology and shotgun proteomic method, 59,391 transcripts and 40,500 unigenes were obtained by TIGR Gene Indices Clustering Tools (TGICL), while 1691 protein species were identified from Mass Spectrometry (MS). Subsequently, all genes and proteins were employed in euKaryotic Orthologous Groups (KOG) classification, Gene Ontology (GO) annotation, and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis to investigate their essential functions. The results indicated that the most abundant pathways were biological metabolic processes. There were 946 unigenes associated with lipid metabolism at the transcriptome level, with 116 proteins at the proteome level; among these, 38 specific proteins were involved in protein-protein interactions, with the majority being related to fatty acid catabolic process. The expression levels of 21 candidate unigenes encoding target proteins were further detected by quantitative real-time polymerase chain reaction (qRT-PCR). Finally, Gas Chromatography Mass Spectrometry (GC-MS) was carried out to determine the fatty acid composition of C. oleifera oil. These findings not only deepened our understanding about the molecular mechanisms of fatty acid metabolism but also offered new evidence concerning the roles of relevant proteins in oilbearing crops. Furthermore, the lipid-associated proteins recognized in this research might be helpful in providing a reference for the synthetic regulation of C. oleifera oil quality by genetic engineering techniques, thus resulting in potential application in agriculture.

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“…Nevertheless, it is recommended that this metric not be used in isolation without consideration of the independent effects of the fatty acids under investigation. Further insight into the interplay between fatty acids may be gained by providing them in combination and increasing the concentration of the denominator while keeping the concentration of the numerator constant, or vice versa 117. impacts upon intra-and inter-organ partitioning of metabolic fuels 118.…”

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confidence: 99%

Polyunsaturated fatty acids as modulators of fat mass and lean mass in human body composition regulation and cardiometabolic health

Monnard

Dulloo

2021

Obesity Reviews

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It is now recognized that the amount and type of dietary fat consumed play an important role in metabolic health. In humans, high intake of polyunsaturated fatty acids (PUFAs) has been associated with reductions in cardiovascular disease risk, improvements in glucose homeostasis, and changes in body composition that involve reductions in central adiposity and, more recently, increases in lean body mass. There is also emerging evidence, which suggests that high intakes of the plant-based essential fatty acids (ePUFAs)-n-6 linoleic acid (LA) and n-3 α-linolenic acid (ALA)-have a greater impact on body composition (fat mass and lean mass) and on glucose homeostasis than the marine-derived long-chain n-3 PUFA-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In addition, high intake of both ePUFAs (LA and ALA) may also have anti-inflammatory effects in humans. The purpose of this review is to highlight the emerging evidence, from both epidemiological prospective studies and clinical intervention trials, of a role for PUFA, in particular ePUFA, in the longterm regulation of body weight and body composition, and their impact on cardiometabolic health. It also discusses current notions about the mechanisms by which PUFAs modulate fat mass and lean mass through altered control of energy intake, thermogenesis, or lean-fat partitioning.

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Lowering the linoleic acid to alpha-linoleic acid ratio decreases the production of inflammatory mediators by cultured human endothelial cells

Cited by 16 publications

References 31 publications

Comparative anti-inflammatory effects of plant- and marine-derived omega-3 fatty acids explored in an endothelial cell line

Comparative anti-inflammatory effects of plant- and marine-derived omega-3 fatty acids explored in an endothelial cell line

Complementary transcriptome and proteome profiling in the mature seeds of Camellia oleifera from Hainan Island

Polyunsaturated fatty acids as modulators of fat mass and lean mass in human body composition regulation and cardiometabolic health

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