In an extended effective operator framework of isospin violating interactions with light mediators, we investigate the compatibility of the candidate signal of the CDMS-II-Si with the latest constraints from DarkSide-50 and XENON-1T, etc. We show that the constraints from DarkSide-50 which utilizes Argon as the target is complementary to that from XENON-1T which utilizes Xenon. Combining the results of the two experiments, we find that for isospin violating interaction with light mediator there is no parameter space which can be compatible with the positive signals from CDMS-II-Si. As a concrete example of this framework, we investigate the dark photon model in detail. We obtain the combined limits on the dark matter mass m χ , the dark photon mass m A ′ , and the kinetic mixing parameter ε in the dark photon model. The DarkSide-50 gives more stringent upper limits in the region of mediator mass from 0.001 to 1 GeV, for m χ 6 GeV in the (m A ′ ,ε) plane, and more stringent constraints for m χ 8 GeV and ε ∼ 10 −8 in the (m χ ,m A 1 predicted background. The results of CoGeNT are inconsistent with the negative results from CDEX [20-23] which utilizes the same type of germanium detector. The CDMS-II-Si reported three WIMP-candidate events. It favors a DM particle mass ∼ 8.6 GeV and a spin-independent DM-nucleon scattering cross section ∼ 1.9 × 10 −41 cm 2 . This results are also in tension with the limits of other experiments, when interpreted in terms of DM-nucleus elastic scattering in the simple DM model.The interpretations of the experimental data involve simplified assumptions. For instance, the interactions between DM particles and target nuclei are often assumed to be isospin conserving, contact, and elastic etc. Simplified assumptions are also adopted on the DM velocity distribution, DM local energy density, nuclear form factors, detector responses, etc. The interpretations of the experimental data can be changed dramatically if some of the assumptions is modified. In order to reconcile the conflicts among the experiments, several mechanisms have been discussed, such as the isospin violating interactions [24][25][26], the light WIMPs-nucleus mediators [27][28][29], exothermic scattering [28][29][30][31][32], the different DM velocity profile [33][34][35][36] and halo-independent [37-39] ,etc.In this work, we reinterpret the results from CDMS-II-Si with the new data from DarkSide-50 [14], XENON1T [13], CDEX-10 [23], etc., in the extended effective operator framework [27,[40][41][42][43] with both isospin violating interactions and light mediators. The effective operator framework is actually the secluded DM scenario, where the DM and the mediator compose a hidden DM sector. The mediator may have sizable coupling with the DM, but its coupling with SM particles is usually very weak by some mechanism. The isospin-violating interaction and light mediators are the popular methods to ameliorate the tensions in the direct detection experiments. In the scenario of isospin violating, the DM particle couples to proton ...