LOX family and ZFPM2 as novel diagnostic biomarkers for malignant pleural mesothelioma

Kim, Minkyu; Kim, Hyun-won; Jang, Mirae; Oh, Sung Soo; Yong, Suk-Joong; Jeong, Yangsik; Jung, Soon-Hee; Choi, Jong-Whan

doi:10.1186/s40364-019-0180-0

Cited by 57 publications

(41 citation statements)

References 41 publications

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“…For example, targeted deletion of PD-1 in myeloid cells was already shown to induce antitumor immunity [ 52 ]. Similar to our results, therapeutic modulation of myeloid polarization through the IFN-γR/STAT1 signaling axis was found to enhance antitumor immune function by activating tumor infiltrating myeloid cells, regulating PD-L1 expression, and promoting immunogenic cell death [ 53 , 54 , 55 , 56 , 57 , 58 ]. New studies indicate that autophagy in addition to its cell-autonomous antitumorigenic functions inhibits cancer development by orchestrating inflammation and immunity.…”

Section: Discussionsupporting

confidence: 89%

Marine Seagrass Extract of Thalassia testudinum Suppresses Colorectal Tumor Growth, Motility and Angiogenesis by Autophagic Stress and Immunogenic Cell Death Pathways

Hernández-Balmaseda¹,

Guerra²,

Declerck

et al. 2021

Marine Drugs

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Marine plants have become an inexhaustible reservoir of new phytopharmaceuticals for cancer treatment. We demonstrate in vitro/in vivo antitumor efficacy of a standardized polyphenol extract from the marine angiosperm Thalassia testudinum (TTE) in colon tumor cell lines (RKO, SW480, and CT26) and a syngeneic allograft murine colorectal cancer model. MTT assays revealed a dose-dependent decrease of cell viability of RKO, CT26, and SW480 cells upon TTE treatment with IC50 values of, respectively, 175, 115, and 60 μg/mL. Furthermore, TTE significantly prevented basal and bFGF-induced angiogenesis in the chicken chorioallantoic membrane angiogenesis assay. In addition, TTE suppressed bFGF-induced migration of endothelial cells in a wound closure assay. Finally, TTE treatment abrogated CT26 colorectal cancer growth and increased overall organism survival in a syngeneic murine allograft model. Corresponding transcriptome profiling and pathway analysis allowed for the identification of the mechanism of action for the antitumor effects of TTE. In line with our in vitro/in vivo results, TTE treatment triggers ATF4-P53-NFκB specific gene expression and autophagy stress pathways. This results in suppression of colon cancer cell growth, cell motility, and angiogenesis pathways in vitro and in addition promotes antitumor immunogenic cell death in vivo.

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Section: Discussionsupporting

confidence: 89%

Marine Seagrass Extract of Thalassia testudinum Suppresses Colorectal Tumor Growth, Motility and Angiogenesis by Autophagic Stress and Immunogenic Cell Death Pathways

Hernández-Balmaseda¹,

Guerra²,

Declerck

et al. 2021

Marine Drugs

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“…Studies have shown that LOX mRNA level was increased in various cancer types, including head and neck squamous cell carcinoma, and breast and prostate cancers (Kirschmann et al, 2002;Lapointe et al, 2004;Erler et al, 2006). Recently, LOX was identified as a potential diagnostic biomarker in MPM (Kim et al, 2020). We also note that patients with high expression of LOX had shorter overall survival time and worse prognosis compared with patients with low expression of LOX (Supplementary Figures 4E, 5E).…”

Section: Discussionsupporting

confidence: 58%

Identification of a Five-Gene Signature for Predicting Survival in Malignant Pleural Mesothelioma Patients

et al. 2020

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Malignant pleural mesothelioma (MPM), predominantly caused by asbestos exposure, is a highly aggressive cancer with poor prognosis. The staging systems currently used in clinics is inadequate in evaluating the prognosis of MPM. In this study, a five-gene signature was developed and enrolled into a prognostic risk score model by LASSO Cox regression analysis based on two expression profiling datasets (GSE2549 and GSE51024) from Gene Expression Omnibus (GEO). The five-gene signature was further validated using the Cancer Genome Atlas (TCGA) MPM dataset. Univariate and multivariate Cox analyses proved that the five-gene signature was an independent prognostic factor for MPM. The signature remained statistically significant upon stratification by Brigham stage, AJCC stage, gender, tumor size, and lymph node status. Time-dependent receiver operating characteristic (ROC) curve indicated good performance of our model in predicting 1-and 2-years overall survival in MPM patients. The C-index was 0.784 for GSE2549 and 0.753 for the TCGA dataset showing moderate predictive accuracy of our model. Furthermore, Gene Set Enrichment Analysis suggested that the five-gene signature was related to pathways resulting in MPM tumor progression. Together, we have established a five-gene signature significantly associated with prognosis in MPM patients. Hence, the five-genes signature may serve as a potentially useful prognostic tool for MPM patients.

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“…At last, the four genes, DTNA, PRR11, TMEM178B, and CACNA1D, were mainly related to gastric cancer or prostate cancer [ 39 – 42 ]. In miRNA-targeted genes of READ, ZFPM2 was recommended as a diagnostic biomarker for malignant pleural mesothelioma and PLXNA1 and PTPRU were related to lung cancer or colon cancer [ 43 – 46 ]. Combining the expression levels of those target genes with TNM stage classification, SERPINE1 is the most important gene associated with tumor size and metastasis status in COAD.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-Related Prognosis Biomarkers from High-Throughput Sequencing Data of Colorectal Cancer

Xing

Yao

Zhang

et al. 2020

BioMed Research International

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Background. Colorectal cancer (CRC) is the third most common cancer in the world, and most of them are adenocarcinomas. CRC could be classified as colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) according to the original tumorigenesis position. Increasing evidences indicated that microRNAs (miRNAs) play an important role in the occurrence of multiple tumors. Methods. In this study, we firstly downloaded miRNA (COAD, 8 controls vs. 455 tumors; READ, 3 controls vs. 161 tumors) and mRNA (COAD, 41 controls vs. 478 tumors; READ, 10 controls vs. 166 tumors) data from The Cancer Genome Atlas (TCGA) database and then used DESeq2, RegParallel, miRDB, TargetScanHuman 7.2, DAVID 6.8, STRING, and Cytoscape software to identify the potential prognosis biomarkers. Results. We identified 175 differential expression miRNAs (DEMs) and 3747 differential expression genes (DEGs) in COAD and 184 DEMs and 3928 DEGs in READ. And then, we obtained 21 (13 in COAD and 8 in READ) DEMs associated with the survival rates, which correlated with 440 (217 in COAD and 223 in READ) overlapping DEGs. Through survival analysis for those overlapping DEGs, we found 11 (8 in COAD and 3 in READ) overlapping DGEs associated with survival rates of patients, which were correlated with 9 (7 in COAD and 2 in READ) DEMs significantly. Conclusion. In this study, we found several candidate prognostic biomarkers which have been identified in various cancers and also found several new prognosis biomarkers of COAD and READ. In conclusion, this analysis based on theoretical knowledge and clinical outcomes we have done needs further confirmation by more researches.

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LOX family and ZFPM2 as novel diagnostic biomarkers for malignant pleural mesothelioma

Cited by 57 publications

References 41 publications

Marine Seagrass Extract of Thalassia testudinum Suppresses Colorectal Tumor Growth, Motility and Angiogenesis by Autophagic Stress and Immunogenic Cell Death Pathways

Marine Seagrass Extract of Thalassia testudinum Suppresses Colorectal Tumor Growth, Motility and Angiogenesis by Autophagic Stress and Immunogenic Cell Death Pathways

Identification of a Five-Gene Signature for Predicting Survival in Malignant Pleural Mesothelioma Patients

MicroRNA-Related Prognosis Biomarkers from High-Throughput Sequencing Data of Colorectal Cancer

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