LPS-aggravated Ferroptosis via Disrupting Circadian Rhythm by Bmal1/AKT/p53 in Sepsis-Induced Myocardial Injury

Lin, Hui; Ji, Fang; Lin, Kong-Qin; Zhu, Yutao; Ye, Wen; Zhang, Long-Hai; Zhao, Jianhua; Pei, Ying-Hao

doi:10.1007/s10753-023-01804-7

Cited by 11 publications

(2 citation statements)

References 53 publications

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“…LPS injection also causes hypothermia ( Mul Fedele et al, 2020 ) and “sickness behavior” that includes reduced locomotor activity ( Santana-Coelho et al, 2023 ). In vitro experiments with cell lines have found a similar reduction of clock gene expression upon LPS treatment ( Liu et al, 2017 ; Lin et al, 2023 ). Furthermore, a decrease in the amplitude of molecular and behavioral rhythms can be achieved by a direct introduction of the proinflammatory cytokine TNFα, but not IL-6 ( Cavadini et al, 2007 ; Westfall et al, 2013 ), and LPS-induced hypothermia is partly mediated by TNFα ( Mul Fedele et al, 2020 ).…”

Section: Effects Of Inflammation On Circadian Rhythmsmentioning

confidence: 82%

Clockwork intruders: Do parasites manipulate their hostsʼ circadian rhythms?

Boy-Waxman,

Olivier,

Cermakian

2024

Current Research in Parasitology & Vector-Borne Diseases

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Section: Effects Of Inflammation On Circadian Rhythmsmentioning

confidence: 82%

Clockwork intruders: Do parasites manipulate their hostsʼ circadian rhythms?

Boy-Waxman,

Olivier,

Cermakian

2024

Current Research in Parasitology & Vector-Borne Diseases

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“…LPS exhibits intricate biological activities, serving as an immune enhancer that elicits a robust immune response during bacterial infections. It activates various immune cells, including T lymphocytes, B lymphocytes, and macrophages, while also promoting cytokine production, complement activation, and overall immune enhancement 4 – 6 .…”

Section: Introductionmentioning

confidence: 99%

Insights from bioinformatics analysis reveal that lipopolysaccharide induces activation of chemokine-related signaling pathways in human nasal epithelial cells

Tan,

Gu,

Zhu

et al. 2024

Sci Rep

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Lipopolysaccharide (LPS) is known to elicit a robust immune response. This study aimed to investigate the impact of LPS on the transcriptome of human nasal epithelial cells (HNEpC). HNEpC were cultured and stimulated with LPS (1 μg/mL) or an equivalent amount of normal culture medium. Subsequently, total RNA was extracted, purified, and sequenced using next-generation RNA sequencing technology. Differentially expressed genes (DEGs) were identified and subjected to functional enrichment analysis. A protein–protein interaction (PPI) network of DEGs was constructed, followed by Ingenuity Pathway Analysis (IPA) to identify molecular pathways influenced by LPS exposure on HNEpC. Validation of key genes was performed using quantitative real-time PCR (qRT-PCR). A total of 97 DEGs, comprising 48 up-regulated genes and 49 down-regulated genes, were identified. Results from functional enrichment analysis, PPI, and IPA indicated that DEGs were predominantly enriched in chemokine-related signaling pathways. Subsequent qRT-PCR validation demonstrated significant upregulation of key genes in these pathways in LPS-treated HNEpC compared to control cells. In conclusion, LPS intervention profoundly altered the transcriptome of HNEpC, potentially exacerbating inflammatory responses through the activation of chemokine-related signaling pathways.

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