Lps-Induced Synthesis and Release of Pge2in Liver Macrophages: Regulation by Cpla2, Cox-1, Cox-2, and Pge2Synthase

Prostaglandin E2 impairs osteogenic and facilitates adipogenic differentiation of human bone marrow stromal cells

“…The inducible enzymes cPLA 2 , COX-2 and mPGES1 are responsible for elevated PGE 2 formation e.g. in response on pro-inflammatory mediators as interleukin 1, tumor necrosis factor α, and lipopolysaccharide [49][50][51]. The marginal basic PGE 2 level is a result of COX-1, cPGES and mPGES2 activities.…”

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

“…Because TNF-␣ and IL-6 were demonstrated to enhance prostaglandin production in macrophages, release of these cytokines may aggravate hepatic lipid accumulation in the course of steatohepatitis (Peters et al, 1990;Ruhl et al, 1992). Further sensitization of Kupffer cells by ethanol, endotoxemia or ROS are likely to enhance PGE 2 -mediated effects on hepatic lipogenesis (Enomoto et al, 1999;Ahmad et al, 2002;Dieter et al, 2002;Yamashina et al, 2005).…”

Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Induces Prostaglandin E 2 Production through Cyclooxygenase 1, Which Is Dependent on the ERK1/2-p-C/EBP-β Pathway

“…Mounting evidence has shown that the pattern of expression of the two COX isoforms is far more complex than the general concept of constitutive (COX-1) and inducible (COX-2) expression (37,40). Influenza virus stimulates the production of PGE 2 via various signaling molecules, including calcium-dependent phospholipase A 2 (cPLA 2 ), COX-1, and COX-2 (41)(42)(43). In our work, COX-1 inhibition by sc-560 at 50 nM did not completely block PGE 2 expression (Fig.…”