Nowadays, the practical tasks of UAVs are becoming more and more complicated and diversified. In the practical flight process, the large-scale changes of the flight environment, the modeling errors, and the external disturbances may induce the instability of the UAV flight system. Meanwhile, the constraints of the UAV attitudes also have to be guaranteed during the flight process. However, most existing control methods still have limitations in handling the constraints and the multisource disturbances simultaneously. To address this problem, in this paper, we focus on the actual output tracking control for the UAV systems with full-state constraints and multisource disturbances. Firstly, a high-order tan-type barrier Lyapunov function (HOBLF) has been constructed for the UAV to maintain the full-state constraints. Secondly, by combining the adaptive backstepping technique and the fuzzy logic systems, the modeling errors and the unknown nonlinearities of the UAV attitude control system can be handled. Moreover, by properly constructing several adaptive laws, the time-varying disturbances existing in the UAV attitude control system can be suppressed. Finally, the full-state-constrained antidisturbance controller is formed, ensuring that the tracking error approaches arbitrarily to small neighborhood and does not violate the given constraints. The simulation results illustrate the feasibility and the advantages of the proposed method.