LRG‐1 promotes fat graft survival through the RAB31‐mediated inhibition of hypoxia‐induced apoptosis

Abstract

Autologous adipose tissue is an ideal soft tissue filling material, and its biocompatibility is better than that of artificial tissue substitutes, foreign bodies and heterogeneous materials. Although autologous fat transplantation has many advantages, the low retention rate of adipose tissue limits its clinical application. Here, we identified a secretory glycoprotein, leucine‐rich‐alpha‐2‐glycoprotein 1 (LRG‐1), that could promote fat graft survival through RAB31‐mediated inhibition of hypoxia‐induced apoptosis. We showed that LRG‐1 injection significantly increased the maintenance of fat volume and weight compared with the control. In addition, higher fat integrity, more viable adipocytes and fewer apoptotic cells were observed in the LRG‐1‐treated groups. Furthermore, we discovered that LRG‐1 could reduce the ADSC apoptosis induced by hypoxic conditions. The mechanism underlying the LRG‐1‐mediated suppression of the ADSC apoptosis induced by hypoxia was mediated by the upregulation of RAB31 expression. Using LRG‐1 for fat grafts may prove to be clinically successful for increasing the retention rate of transplanted fat.

CCNB1 may as a biomarker for the adipogenic differentiation of adipose-derived stem cells in the postoperative fat transplantation of breast cancer

“…During the process, ADSCs can stimulate angiogenesis through differentiation into epithelial cells and release angiogenic factors by paracrine activity. Finally, dedifferentiation, which a mature adipocyte is reverted to an undifferentiated progenitor-like status under both physiological and pathological conditions, also has been reported as a mechanism explaining adipocyte plasticity ( 45 - 48 ). Therefore, the molecular mechanisms underlying the adipogenic differentiation of ADSCs still should be explored to facilitate the success of ADSCs-based therapies after breast cancer surgery.…”

Correlation between LRG1 and Adipokines in Psoriasis

“…LRG1 has been shown to exert a benefcial impact on the survival and function of adipocytes. Tis can be attributed to its ability to inhibit adipocyte apoptosis through the RAS oncogene family member (RAB31) protein [23]. Currently, limited research is available on the connection between LRG1 and other adipokines.…”