LRRC10 (Leucine‐Rich Repeat Containing Protein 10) and REEP5 (Receptor Accessory Protein 5) as Novel Regulators of Cardiac Excitation‐Contraction Coupling Structure and Function

<p>Identification of Important Modules and Biomarkers in Breast Cancer Based on WGCNA</p>

“…31,32 Chiamvimonvat et al demonstrated that REEP5, as the only REEP family protein enriched in the heart, is a new regulator of cardiac excitation-contraction coupling. 33 Studies have also shown that the expression of REEP5 is down-regulated in lung and gastric cancer. 34,35 REEP5 knockdown affected CXCR1 and down-regulated the IL-8-mediated cellular response, which significantly reduced the growth and invasion of lung cancer cells.…”

Identification and characterization of the receptors of a microneme adhesive repeat domain of Eimeria maxima microneme protein 3 in chicken intestine epithelial cells

“…REEPs are a group of receptor expression-enhancing proteins that can help the proper functional expression of G-protein-coupled receptors ( Park et al, 2016 ; Chiamvimonvat and Song, 2018 ). The REEP 5 gene, also known as DP1, is one of the DP1/Yop1p protein family members that engage in endoplasmic reticulum tubule formation ( Yang et al, 2012 ).…”

“…REEP5 is a novel regulator of cardiac excitation‐contraction by shaping the morphology of the junctional sarcoplasmic reticulum ( SR ), whereas REEP5 deficiency led to a defect in the SR and T‐tubules connections ( Yao et al, 2018 ). Meanwhile, downregulation of REEP5 was observed in a heart failure model induced by chronic pressure, suggesting the potential role of REEP5 in cardiac dysfunction ( Chiamvimonvat and Song, 2018 ). In addition, REEP5 is associated with neuropsychiatric and retinal disorders and hereditary spastic paraplegia ( Park, et al, 2016 ; Chiamvimonvat and Song, 2018 ).…”

“…Meanwhile, downregulation of REEP5 was observed in a heart failure model induced by chronic pressure, suggesting the potential role of REEP5 in cardiac dysfunction ( Chiamvimonvat and Song, 2018 ). In addition, REEP5 is associated with neuropsychiatric and retinal disorders and hereditary spastic paraplegia ( Park, et al, 2016 ; Chiamvimonvat and Song, 2018 ). Yop1 is a REEP5 homolog of Plasmodium berghei , and disruption of the Yop1 expression may cause the defect for parasite development and invasion of erythrocytes ( Shi et al, 2020 ).…”

The Role of Meis Transcription Factors in Cardiomyocytes

“…Despite the fact that 28 genes are a low input for a gene ontology analysis, the categories found are closely related to the phenotypes described upon Meis loss of function, which suggests this gene list is relevant to the mechanisms involved in the phenotypic alterations. Furthermore, Fhl2 and Lrrc10, which are strongly downregulated, have been previously as hypertrophic growth repressor (Okamoto et al, 2013) and cardiac excitation-contraction coupling regulator, respectively (Chiamvimonvat & Song, 2018). By contrast, nothing has been reported before about EfnB3 expression or function in the heart, despite of being one of the most downregulated in Meis mutants.…”