LSD-induced hallucinogen persisting perception disorder treatment with clonidine: an open pilot study

Hallucinogen Persisting Perception Disorder

“…The remission was sustained as it was possible to discontinue the naltrexone after 2 months without precipitating a relapse Lerner et al [2000] Clonidine 8 Observational study 6 of the 8 subjects (2 dropped out) received clonidine (0.025 mg, three times a day) for 2 months which alleviated LSD-related HPPD Lerner et al [2001] Clonazepam 2 Case reports 2 outpatients with LSD-induced HPPD were successfully treated with clonazepam. They had not responded to low doses of classic antipsychotics or low-potency benzodiazepines Lerner et al [2002a] Reboxetine 1 Case report During a 6-month follow-up period on reboxetine (6mg/day) no exacerbations of visual disturbance were reported Lerner et al [2003] Clonazepam patterns to mental trauma and weak self esteem to other psychophysic vulnerabilities [Hermle et al 2008].…”

“…They had not responded to low doses of classic antipsychotics or low-potency benzodiazepines Lerner et al [2002a] Reboxetine 1 Case report During a 6-month follow-up period on reboxetine (6mg/day) no exacerbations of visual disturbance were reported Lerner et al [2003] Clonazepam patterns to mental trauma and weak self esteem to other psychophysic vulnerabilities [Hermle et al 2008]. Additionally, only a small spectrum of hallucinogens seem capable of eliciting flashbacks, with LSD being the leading causative agent.…”

Clinical Characteristics of Individuals With Schizophrenia and Hallucinogen Persisting Perception Disorder: A Preliminary Investigation

“…Based on the CGI improvement scale, response to antipsychotic treatment was categorized as "good" (1 or 2), "fair" (3), and "none/worse" (4 to 7; Guy, 1976). None of the subjects included in the study received medications particularly targeted at treating HPPD, such as those previously reported (Lerner et al, 2000;Lerner et al, 2003).…”

“…Despite the use of antipsychotic medication, which has been reported to be useful in the treatment of HPPD-related visual disturbances in the general population (Anderson & O'Malley, 1972;A. G. Lerner et al, 2000;Lerner et al, 2003;Moskowitz, 1971), little is known about the clinical characteristics and subjective experiences of co-occurring schizophrenia and HPPD.…”

Halluzinogen-induzierte psychische Störungen

“…In einer weiteren offenen Studie wurden 8 Patienten mit der Diagnose "Hallucinogen Persisting Perception Disorder" (HPPD) 2 Monate mit 3 0,025 mg Clonidin behandelt. 6 Patienten zeigten unter Clonidin eine deutliche Besserung [47]. SSRIs scheinen die Symptome eines HPPD bei Therapiebeginn zu verschlechtern.…”