<b>Adenylate kinase 2 deficiency limits survival and </b><b>regulates various genes during larval stages of </b><b><i>Drosophila melanogaster </i></b>

Abstract

The enzyme adenylate kinase (AK) reversibly converts ATP+AMP to 2 ADPs and plays a role in cellular energy homeostasis (1). To date, 8 vertebrates AK isoenzymes (AK1-AK8) have been reported(2). Among these, AK2 is uniquely located in the mitochondrial intermembrane space, and is highly expressed in human liver, kidney, and heart tissues (3). AK2 provides ADP to the adenine nucleotide translocator in the inner membrane of mitochondria, which promotes the exchange of ADP with ATP.