&lt;b&gt;Avaliação do equilíbrio oxidativo na gestação e perinatologia equina&lt;/b&gt;

Souza, Danilo França de

doi:10.11606/d.10.2017.tde-22032017-165141

Cited by 1 publication

(1 citation statement)

References 24 publications

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“…However, the two groups of neonates in this study had a higher concentration of TBARS soon after birth and remained high until three days of life. The oxidative capacity also remained stable during these first three days and the increased demand for oxygen due to increased metabolism may influence lipid peroxidation [21]. Additionally, we observed a progressive decrease in lipid peroxidation (TBARS) from birth to thirty days of life, which has not been reported in previous studies in newborn horses, but has also been observed in newborn dogs, with lower lipid peroxidation during the first hour of life [22].…”

Section: Discussionsupporting

confidence: 74%

Comparative Assessment of Oxidative and Antioxidant Parameters in Mule and Horse Neonates during Their First Month of Extrauterine Adaptation

Riccio,

Costa,

Alonso

et al. 2023

Animals

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After parturition, a rapid transition occurs from the intrauterine to the extrauterine milieu, exposing neonates to physiological circumstances characterized by oxidative conditions that instigate the generation of reactive oxygen species. These free radicals play pivotal roles in physiological processes; however, an imbalance between their production and the removal of antioxidants can result in severe cellular damage. The main objective of this study was to compare the oxidative and antioxidant profiles in mule and horse neonates immediately post-parturition, as well as at subsequent time points (1, 6, 12, and 24 h, 7 and 30 days) during their extrauterine existence. The parameters assessed included the systemic concentrations of Thiobarbituric Acid Reactive Substances (TBARS) and carbonyl groups; the activities of the antioxidants superoxide dismutase (SOD) and glutathione peroxidase (GPx); and the levels of the total, indirect, and direct bilirubin. Our results showed no interaction effect between the neonatal groups and the assessed time points for the variables under investigation. Notably, the concentrations of TBARS, as a marker of lipid peroxidation, and bilirubin were consistently lower in the mules, whereas the glutathione peroxidase (GPx) activity exhibited higher levels in this group. The bilirubin levels were notably reduced in the mule neonates. The TBARS demonstrated a progressive decrease over the observation period in both groups, while the GPx activity remained relatively stable from birth to 7 days, with a substantial increase evident at the 30-day mark. Protein oxidation was not affected by the group and time, while for the SOD values, all times were statistically similar, except for the lower activity at T1h. Consequently, our findings lead us to the conclusion that neonatal mules and horses manifest distinct patterns of oxidative activity and antioxidant capacity during the initial month of their extrauterine existence, potentially indicative of different adaptation mechanisms to the extrauterine environment.

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Section: Discussionsupporting

confidence: 74%