<b>Carvedilol Prevents Myocardial Fibrosis in Hamsters</b>

Abstract

SUMMARYThe objective of the present study was to determine if carvedilol protects against myocardial degeneration and fibrotic change, and reduces mortality in TO2 hamsters.Carvedilol was administered intraperitoneally to 8 week-old TO2 hamsters for 21 weeks at a dose of 11 mg/kg/day. There were 15 TO2 hamsters in the carvedilol group (group C) and 10 in the untreated group (group N). The control group consisted of 11 Fb hamsters (group F). The mortality rate was determined from the number of surviving hamsters after 29 weeks. Myocardial fibrosis was evaluated by MRI and histopathological examination. EF and LVDd were determined by echocardiography at 8 and 29 weeks, while the MRI score was calculated at 29 weeks.Mortality, histopathological fibrosis, and MRI score were all lower in group C than in group N. Carvedilol had a protective effect against myocardial fibrosis and decreased the mortality rate in TO2 hamsters. ( 2-4) Following this, β-blocker therapy became used for the treatment of chronic heart failure.We previously performed MRI studies in a hamster model of cardiomyopathy (Bio 14.6 hamster) and found abnormal sites of enhancement as well as delayed enhancement. We proposed that the enhanced areas were regions of myocardial degeneration and fibrosis. 5) Carvedilol is a β-blocker that also has α-blocking and antioxidant effects, which have been shown to reduce the mortality rate of patients with moderate to severe chronic cardiac failure by 35% to 65%, in addition to also lowering the rehospitalization rate. 3,4) In the present study, we assessed the effects of carvedilol [6][7][8] in another hamster model of dilated cardiomyopathy, the BioFrom the

The Effects of Carvedilol on Cardiac Function and the AKT/XIAP Signaling Pathway in Diabetic Cardiomyopathy Rats

“…Thirdly, as is widely known, myocardium fibrosis is one of the important hallmarks of DCM [23]. Previous studies have suggested that carvedilol can not only prevent myocardium fibrosis in hamsters, but can also attenuate acute infarction-induced myocardial fibrosis in rats [24,25]. Our results indicated that carvedilol significantly prevented myocardium fibrosis in experimental diabetic rats (fig.…”

Carvedilol-Afforded Protection against Daunorubicin-Induced Cardiomyopathic Rats In Vivo: Effects on Cardiac Fibrosis and Hypertrophy

“…Previous studies reported that carvedilol could prevent myocardial fibrosis in hamster models of progressive cardiomyopathy [35]. It is well established that TGF- β 1 is a fibrogenic cytokine which is an important modulator in the ventricular remodeling process [36], and carvedilol treatment reduced the expression of TGF- β 1 [37].…”

Correlation Between Left Ventricular Diastolic Function and Ejection Fraction in Dilated Cardiomyopathy Using Magnetic Resonance Imaging With Late Gadolinium Enhancement

“…[1][2][3] In recent years, investigation of LGE in DCM patients, who have relatively thin myocardium, as well as in patients with myocardial infarction and HCM, has revealed various imaging patterns. [5][6][7][8]15,16 In the present study, the LV pattern of LGE on cardiac MRI and correlations between the LGE rate and LV systolic function or LV diastolic function were investigated.…”

“…Cine MRI data on the area between the LV base and apex were transmitted to Advantage Wind (version 5.0) software on a work station (GE Yokogawa Medical System) for analysis with cardiac and flow analysis tools. The LV endocardial border at the end-diastolic and end-systolic phases was traced automatically and manually to calculate the LV end-diastolic volume (LVEDV: cm 3 ), LV end-systolic volume (LVESV: cm 3 ) and LV ejection fraction (EF: %). The endocardium and epicardium at the LV end-diastolic phase were also traced automatically and manually to calculate the LV mass (g) based on the myocardial tissue weight coefficient (1.05 g/ml).…”

“…1 There have been some reports that myocardial lesions can be evaluated from their enhancement by Gd-DTPA on T1-weighted images. 2,3 It was also reported that the region of myocardial fibrosis is demonstrated by late gadolinium enhanced imaging (LGE), which is performed at 20 min after Gd-DTPA inversion recovery (IR) imaging. 4,5 In recent years, cardiac MRI findings have been investigated in patients with idiopathic dilated cardiomyopathy (DCM) and relatively thin ventricular walls.…”