&lt;b&gt;Effects of the antiepileptic drugs topiramate and lamotrigine on bone metabolism in &lt;/b&gt;&lt;b&gt;rats &lt;/b&gt;

Kanda, Junkichi; Izumo, Nobuo; Kobayashi, Yoshiko; Onodera, Kenji; Shimakura, Taketoshi; Yamamoto, Noriaki; Takahashi, Hideaki; Wakabayashi, Hiroyuki

doi:10.2220/biomedres.38.297

Cited by 13 publications

(3 citation statements)

References 41 publications

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“…Recently, several other drugs were also clearly shown to cause bone fragility. We have previously reported the effects of antidiabetic (11) and antiepileptic (12,13) agents on bone metabolism; these led to enhanced bone fragility. The present study investigates the effects of calcineurin inhibitors, which are immunosuppressants that have greatly contributed to the advancement of transplant therapy in recent years, on bone metabolism.…”

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confidence: 99%

Effects of the calcineurin inhibitors cyclosporine and tacrolimus on bone metabolism in rats

et al. 2018

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Immunosuppressive therapy is considered as one of the factors inducing to the onset of osteoporosis after organ transplantation. Chronic immunosuppressive therapy after transplantation is required for organ transplant patients, and it is important to prevent the occurrence of osteoporotic fractures to maintain the quality of life in patients. In this study, we examined the effects of cyclosporine and tacrolimus on bone metabolism in rats. Five-week-old male Wistar rats were treated orally with 15 mg/kg cyclosporine or 1.5 mg/kg tacrolimus daily for 4 weeks. Each of cyclosporine and tacrolimus significantly reduced the bone strength of the femoral mid-diaphysis and bone mineral density of the tibia and femur. Bone histomorphometry showed that the administration of both drugs resulted in a decrease in bone volume, number and thickness of trabeculae, and an increase in trabecular separation. Bone formation parameters such as osteoid volume, osteoblast surface, mineralizing surface, mineral apposition rate, and bone formation rate significantly increased in the cyclosporine-treated group. Bone resorption parameters such as eroded surface, osteoclast surface, and osteoclast number significantly increased in both the cyclosporine- and the tacrolimus- treated groups. These results showed that cyclosporine increases both bone formation and bone resorption, leading to a high-turnover bone loss, and that tacrolimus increases bone resorption without affecting bone formation, leading to bone loss.

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confidence: 99%

Effects of the calcineurin inhibitors cyclosporine and tacrolimus on bone metabolism in rats

et al. 2018

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“…ASMs that have a weak carbonic anhydrase mechanism of action include topiramate and zonisamide, which can cause metabolic acidosis and decrease bone mineralization in animal models. 52 One-year follow-up of a female cohort of women on topiramate did not demonstrate clinically significant BMD loss, but did show increased bone turnover. 53 A recent cohort study of adults showed no significant BMD loss after 13 months of zonisamide monotherapy; however, the range of doses was 50 to 300 mg, whereas many neurologists treat patients with doses of over 300 mg daily.…”

Section: Bone Mineral Densitymentioning

confidence: 93%

Long-Term Effects of Antiseizure Medications

LoPinto-Khoury

2022

Semin Neurol

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Most patients with epilepsy will benefit from seizure control with one of an array of chronic antiseizure medications. Knowledge of the potential long-term effects of these medications is critical to prevent adverse consequences on overall health. Antiseizure medications vary in their capacities to affect the brain and peripheral nerves, hormones, bone mineralization, cardiovascular risk, renal health, hepatic, hematological, and dermatological systems. Understanding of pathophysiology and population risk has evolved, although most of the data available are still on older generation antiseizure medications such as phenytoin, carbamazepine, and valproic acid. The enzyme-inducing properties of some antiseizure medications make their effects on cardiovascular risk and bone health detrimental. Few clear guidelines exist for monitoring long-term effects of medication therapy for epilepsy. When selecting an antiseizure medication, consideration should be given to the individual patient's risks of adverse consequences on other organ systems. During monitoring of patients on chronic therapy, screening tools such as metabolic panels and bone density measurements can help stratify risk and guide management.

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“…Quercetin is a natural plant alkaloid estrogen with strong estrogen antagonist activity [1] . As we all know, quercetin is widely distributed in the plant kingdom and has the biological activities of a variety of enzymes, which is increasingly widely valued by modern people.…”

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Quercetin on Bone Metabolism and Serum Osteocalcin in Osteoporotic Rats

Cai,

Xu,

Chen

2023

IJPS

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Effect of Quercetin in Osteoporotic RatsOsteoporosis has gradually become a common human disease. The main cause of this common disease is caused by the degradation of the internal structure of bone and soft tissues, which causes great troubles to the lives of elderly patients. Quercetin is a flavonoid drug that is commonly used to treat osteoporosis. Therefore, it is very important to study the pharmacological and clinical effects of quercetin. The purpose of this article is to solve some problems in the clinical application of quercetin and to explore the effect of quercetin on bone metabolism and serum osteocalcin in osteoporotic rats. Taking 90 rats as the research object, an animal model of osteoporosis was constructed. The rats were randomly divided into sham operation control group, ovariectomy control group and quercetin observation group. Except for the sham operation group, all rats were subjected to ovariectomy, and the rats in the quercetin observation group were given quercetin drug intervention. 1 w later, all rats were tested for bone metabolism and serum osteocalcin levels, and related data were recorded and analyzed. The results of the study showed that with the intervention of quercetin, the bone metabolism index of osteoporosis rats increased from the original (53.49±3.41) to (86.27.2±4.22), and the serum calcium level from the original (16.28±0.56) μg/l increased to (37.64±2.35) μg/l, and the bone mineral density and bone tissue structure of rats also improved accordingly. It can be seen that quercetin can promote bone metabolism in osteoporotic rats, increase the content of osteocalcin in rats, and have a good effect on the prevention and treatment of osteoporosis.

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<b>Effects of the antiepileptic drugs topiramate and lamotrigine on bone metabolism in </b><b>rats </b>

Cited by 13 publications

References 41 publications

<b>Effects of the calcineurin inhibitors cyclosporine and tacrolimus on bone metabolism in </b><b>rats </b>

<b>Effects of the calcineurin inhibitors cyclosporine and tacrolimus on bone metabolism in </b><b>rats </b>

Long-Term Effects of Antiseizure Medications

Quercetin on Bone Metabolism and Serum Osteocalcin in Osteoporotic Rats

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