&lt;b&gt;&lt;i&gt;Aedes communis&lt;/i&gt;&lt;/b&gt; Reactivity Is Associated with Bee Venom Hypersensitivity: An in vitro and in vivo Study

Scala, Enrico; Pirrotta, L.; Uasuf, Carina Gabriela; Mistrello, Gianni; Amato, Stefano; Guerra, Emanuele; Locanto, Maria; Meneguzzi, Giorgia; Giani, Mauro; Cecchi, Lorenzo; Abeni, Damiano; Asero, Riccardo

doi:10.1159/000488866

Cited by 12 publications

(12 citation statements)

References 14 publications

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“…Aedes communis reactivity has been associated with bee venom hypersensitivity in a large group of Italian individuals reporting immediate reactions after mosquito bites. 244 The allergen composition of Polistes dominulus venom (PDV) is very similar to that of YJV, and the most important allergens are Pol d 1 (phospholipase A1), Pol d 3 (dipeptidyl peptidase IV), and Pol d 5 (antigen 5). Pol d 3 is a very good reagent, but it cross-binds with both Apis and Vespula dipeptidyl peptidase IV.…”

Section: Hymenoptera and Insectsmentioning

confidence: 99%

A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

Ansotegui¹,

Melioli²,

Canonica³

et al. 2020

World Allergy Organization Journal

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Precision allergy molecular diagnostic applications (PAMD@) is increasingly entering routine care. Currently, more than 130 allergenic molecules from more than 50 allergy sources are commercially available for in vitro specific immunoglobulin E (sIgE) testing. Since the last publication of this consensus document, a great deal of new information has become available regarding this topic, with over 100 publications in the last year alone. It thus seems quite reasonable to publish an update. It is imperative that clinicians and immunologists specifically trained in allergology keep abreast of the new and rapidly evolving evidence available for PAMD@. PAMD@ may initially appear complex to interpret; however, with increasing experience, the information gained provides relevant information for the allergist. This is especially true for food allergy, Hymenoptera allergy, and for the selection of allergen immunotherapy. Nevertheless, all sIgE tests, including PAMD@, should be evaluated within the framework of a patient's clinical history, because allergen sensitization does not necessarily imply clinical relevant allergies.

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Section: Hymenoptera and Insectsmentioning

confidence: 99%

A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

Ansotegui¹,

Melioli²,

Canonica³

et al. 2020

World Allergy Organization Journal

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“…There is no evidence that Blastophaga has any venom at all, let alone specific venom like other wasps. Nevertheless, very recently, a significant relationship between mosquito sensitization and either extract or single bee venom components has been described [8]. …”

Section: Discussionmentioning

confidence: 99%

Mastocytosis and the Fig Wasp (<b><i>Blastophaga psenes</i></b>)

Armentia

Pineda

Fernandez-Cortés

et al. 2019

Int Arch Allergy Immunol

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Background: Mastocytosis involves the abnormal proliferation of mast cells and clinical variability. In the case of anaphylaxis, the triggering antigen, often associated with Hymenoptera allergens, must be identified. The common fig (Ficus carica) requires the fig wasp (Blastophaga psenes) for pollination. Objective: We evaluated the ingestion of B. psenes as a trigger of anaphylaxis in patients with mastocytosis. Material and Methods: Skin prick tests (SPTs) and specific immunoglobulin E to the possible involved allergens were carried out in the patient and in 4 controls allergic to Hymenoptera and fig. Given the possibility of hidden allergens, we studied the source (figs of various origins) and possible hypersensitivity to Hymenoptera allergens, including the fig wasp (B. psenes). Results: In all subjects, the SPT resulted in a wheal (larger than with histamine) with the extract of the inferior part of the female fig but not with the male extract (lower pole and stem). Immune detection was made with the stem and inferior part of figs and venom of Polistes and Vespula. Recognition bands were observed at 25 kDa with female fig extracts that were also recognized by the patient with anaphylaxis to Hymenoptera venom. Conclusions: We cannot exclude the possibility that the ingestion of fig with Blastophaga antigens may have triggered anaphylaxis in our patient.

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“…Skin testing and immunotherapy is also possible with whole body extracts 60 . A significant correlation between allergic reactions to Aedes communis and bee venom hypersensitivity suggests the occurrence of a “bee-mosquito” cross reactivity syndrome 63 …”

Section: Rare Allergens (Biting Insects)mentioning

confidence: 99%

Worldwide perspectives on venom allergy

Korošec

Jakob

Harb

et al. 2019

World Allergy Organization Journal

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Venom immunotherapy is the standard of care for people with severe reactions and has been proven to reduce risk of future anaphylactic events. There is a moral imperative to ensure production, supply and worldwide availability of locally relevant, registered, standardized commercial venom extracts for diagnosis and treatment. Insects causing severe immediate allergic reactions vary by region worldwide. The most common culprits include honeybees (Apis mellifera), social wasps including yellow jackets (Vespula and Dolichovespula), paper wasps (Polistes) and hornets (Vespa), stinging ants (Solenopsis, Myrmecia, Pachycondyla, and Pogonomyrmex), and bumblebees (Bombus). Insects with importance in specific areas of the world include the Australian tick (Ixodes holocyclus), the kissing bug (Triatoma spp), horseflies (Tabanus spp), and mosquitoes (Aedes, Culex, Anopheles). Reliable access to high quality venom immunotherapy to locally relevant allergens is not available throughout the world. Many current commercially available therapeutic vaccines have deficiencies, are not suitable for, or are unavailable in vast areas of the globe. New products are required to replace products that are unstandardized or inadequate, particularly whole-body extract products. New products are required for insects in which no current treatment options exist. Venom immunotherapy should be promoted throughout the world and the provision thereof be supported by health authorities, regulatory authorities and all sectors of the health care service.

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<b><i>Aedes communis</i></b> Reactivity Is Associated with Bee Venom Hypersensitivity: An in vitro and in vivo Study

Cited by 12 publications

References 14 publications

A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

Mastocytosis and the Fig Wasp (<b><i>Blastophaga psenes</i></b>)

Worldwide perspectives on venom allergy

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