2013
DOI: 10.1159/000351056
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<b><i>Anisakis</i></b> Allergy Component-Resolved Diagnosis: Clinical and Immunologic Differences between Patients from Italy and Spain

Abstract: Background:Anisakissimplex is the main organism responsible for the zoonotic disease anisakiasis which follows the ingestion of live larvae present in raw or undercooked marine fish. Clinical features include severe epigastric pain, frequently accompanied by severe allergic reactions. We investigated the prevalence of immunoglobulin E (IgE) specific for 5 Anisakis allergens in Italian patients sensitized or allergic to the parasite. The results were compared with those obtained previously in a similar Spanish … Show more

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Cited by 23 publications
(19 citation statements)
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“…Humans may also have different susceptibilities to these zoonotic nematodes4. Caballero et al 56. found differences in clinical and immunological symptoms between Italian and Spanish Anisakis spp.…”
Section: Discussionmentioning
confidence: 98%
“…Humans may also have different susceptibilities to these zoonotic nematodes4. Caballero et al 56. found differences in clinical and immunological symptoms between Italian and Spanish Anisakis spp.…”
Section: Discussionmentioning
confidence: 98%
“…In a recent issue of the International Archives of Allergy and Immunology, Caballero et al [14] focused on the importance of using component-resolved diagnosis to reveal IgE sensitization to Anisakis to avoid problems related to specificity while maintaining good sensitivity. The study was carried out by comparison of the specific IgE responses in sera from symptomatic and asymptomatic patients in Italy and Spain against a panel of 4 recombinant Anisakis allergens (Ani s 1, Ani s 5, Ani s 9, and Ani s 10; response measured by dot blot assay) and a purified native allergen (Ani s 4; response measured by Western blot).…”
mentioning
confidence: 99%
“…Differences in IgE reactivity in sera from patients infected with Anisakis may reflect interindividual variations in immunological responses or a different frequency of exposure, as reported for other allergens [15]; however, such differences may also be due to a bias in patient selection when comparing different populations. In the study by Caballero et al [14], the higher frequency of patients with high levels of anti- Anisakis IgE antibodies (CAP class 6) in the Spanish population may at least partly explain the higher reactivity of the sera. However, the observation that some allergens (e.g.…”
mentioning
confidence: 99%
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“…Though Ani s 7 is an indicator of both acute Anisakis infections and Anisakis-related chronic urticarial, IgE response to Ani s 1 is mainly associated with chronic stage of GAA [92,94,96]. Caballero et al reported that Anisakis IgE CAP classes 1 and 2 were associated with a high probability of asymptomatic sensitization (66.7%), whereas classes 4 or above were associated with a high probability of Anisakis allergy (95.2%) [97].…”
Section: Biological Characteristics Of Anisakis Allergensmentioning
confidence: 99%