<b><i>Aspergillus </i></b>Vertebral Osteomyelitis Complicating Pulmonary Granuloma in an Immunocompetent Adult

Abstract

Objective: The aim of this report is to describe a case with Aspergillus vertebral osteomyelitis complicating pulmonary granuloma in an immunocompetent adult. Clinical Presentation and Intervention: A 53-year-old male patient was found to have lesions on lumbar vertebra 5 months after thoracoscopic resection of pulmonary granuloma that lacked a definite etiology. Three operations on the lumbar lesions were performed successively; however, an Aspergillus infection was not confirmed until hyphae were clearly detected at the last surgery. The patient was treated with voriconazole and recovered well. Conclusion: This case shows that simultaneous occurrence of granulomatous nodules in the lung and vertebral lesions should raise suspicion of aspergillosis, even in immunocompetent patients.

Minimally invasive debridement and drainage using intraoperative CT-Guide in multilevel spondylodiscitis: a long‐term follow‐up study

“…Fungal discitis is rare and to date, only case reports exist [26]. Fungal discitis is usually due to molds [29][30][31][32] and Candida species [33][34][35][36][37][38], which are consistent with our results.…”

Invasive pulmonary aspergillosis with Aspergillus vertebral osteomyelitis in an HIV-infected adult: a case report

“…9,12,13 Surgical intervention is indicated in those patients with complications due to vertebral involvement. 7 In this case, initial treatment with oral itraconazole was indicated. Despite this treatment, invasive pulmonary aspergillosis was not controlled.…”

“…5,6 Among invasive forms, Aspergillus osteomyelitis has been described as a diagnostic challenge due to its rarity and high mortality. 7 We report a case of an HIV-infected patient with low adherence to antiretroviral therapy (ART) who presented with Aspergillus spp. vertebral osteomyelitis.…”

“…5,6 Among invasive forms, Aspergillus osteomyelitis has been described as a diagnostic challenge due to its rarity and high mortality. 7…”

Invasive Pulmonary Aspergillosis in the Epidural Space in a Patient with Acute Myelogenous Leukemia with Myelodysplasia-related Changes: A Case Study and Literature Review of Vertebral Aspergillosis in Japan

“…Invasive pulmonary aspergillosis generally occurs in patients with severe immunodeficiency and can be a major cause of morbidity and mortality ( 1 ). Aspergillus osteomyelitis is a debilitating and severe form of invasive aspergillosis, but it is extremely rare with a high mortality rate ( 2 , 3 ). Vinas et al ( 4 ) and Studemeister et al ( 5 ) reviewed the literature on 41 and 21 previous aspergillus vertebral osteomyelitis cases, respectively.…”