&lt;b&gt;&lt;i&gt;Lifestyle Genomics&lt;/i&gt;&lt;/b&gt;: Addressing the Multifactorial Nature of Personalized Health

Mutch, David M.; Zulyniak, Michael A.; Rudkowska, Iwona; Tejero, M. Elizabeth

doi:10.1159/000492297

Cited by 8 publications

(6 citation statements)

References 70 publications

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“…NDs may be illnesses with a dynamic state in which pathophysiological alternation and clinical symptoms develop in a certain range over time. Many chronic diseases have a multifactorial origin associated with factors of genetic, environmental, socioeconomic, cultural, and personal lifestyle predispositions [159][160][161]. The links between genetic and environmental factors were documented by mechanisms of epigenetics such as DNA methylation, DNA hydromethylation, chromatin remodeling, histone modifications, non-coding RNAs, and microRNAs, among others.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines

Tanaka

Toldi

Vécsei

2020

IJMS

198

197

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Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative diseases (NDs), presenting a broad range of symptoms from motor dysfunctions to psychobehavioral manifestations. A common clinical course is the proteinopathy-induced neural dysfunction leading to anatomically corresponding neuropathies. However, current diagnostic criteria based on pathology and symptomatology are of little value for the sake of disease prevention and drug development. Overviewing the pathomechanism of NDs, this review incorporates systematic reviews on inflammatory cytokines and tryptophan metabolites kynurenines (KYNs) of human samples, to present an inferential method to explore potential links behind NDs. The results revealed increases of pro-inflammatory cytokines and neurotoxic KYNs in NDs, increases of anti-inflammatory cytokines in AD, PD, Huntington’s disease (HD), Creutzfeldt–Jakob disease, and human immunodeficiency virus (HIV)-associated neurocognitive disorders, and decreases of neuromodulatory KYNs in AD, PD, and HD. The results reinforced a strong link between inflammation and neurotoxic KYNs, confirmed activation of adaptive immune response, and suggested a possible role in the decrease of neuromodulatory KYNs, all of which may contribute to the development of chronic low grade inflammation. Commonalities of multifactorial NDs were discussed to present a current limit of diagnostic criteria, a need for preclinical biomarkers, and an approach to search the initiation factors of NDs.

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Section: Discussionmentioning

confidence: 99%

Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines

Tanaka

Toldi

Vécsei

2020

IJMS

198

197

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“…There are tens of thousands of PubMed articles which touch on genetics/genomics and the environment, with articles on lifestyle also gaining momentum [9-11]. As might be expected, some of the most commonly mentioned potential lifestyle/environment risk/effect modifiers include smoking, exercise or the lack thereof (a sedentary lifestyle), pollution of various types, alcohol, social environment, vitamins or dietary supplements, dietary fats, stress, intestinal microbiota, pesticides, fruits and vegetables, and meats (especially red or processed meats).…”

Section: Growing Environmental and Lifestyle Opportunities Includingmentioning

confidence: 99%

Gene-Centric Database Reveals Environmental and Lifestyle Relationships for Potential Risk Modification and Prevention

Martin¹

2021

Lifestyle Genomics

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The database at Nutrigenetics.net has been under development since 2007 to facilitate the identification and classification of PubMed articles relevant to human genetics. A controlled vocabulary (i.e., standardized terminology) is used to index these records, with links back to PubMed for every article title. This enables the display of indexes (alphabetical subtopic listings) for any given topic, or for any given combination of topics, including for genes and specific genetic variants. Stepwise use of such indexes (first for one topic, then for combinations of topics) can reveal relationships that are otherwise easily overlooked. These relationships include environmental and lifestyle variables with potential relevance to risk modification (both beneficial and detrimental), and to prevention, or at least to the potential delay of symptom onset for health conditions like Alzheimer disease among many others. Thirty-four specific genetic variants have each been mentioned in at least ≥1,000 PubMed titles/abstracts, and these numbers are steadily increasing. The benefits of indexing with standardized terminology are illustrated for genetic variants like MTHFR 677C-T and its various synonyms (e.g., rs1801133 or Ala222Val). Such use of a controlled vocabulary is also helpful for numerous health conditions, and for potential risk modifiers (i.e., potential risk/effect modifiers).

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“…Sleep is influenced by several other lifestyle factors [153], including diet, exercise, smoking, and medications. Further research is needed to understand the mechanisms underlying the effects of all these factors.…”

Section: Role Of Epigenetic Regulations In Sleep Under the Influence Of Other Lifestyle Factorsmentioning

confidence: 99%

“…Dietary components were also proposed to influence histone modification [171]. Gut-brain axis and bidirectional cross-talk were being investigated extensively in many human health conditions [153]. A diverse range of methods was applied to modulate the gut microbiome, including antibiotic therapy, fecal microbiota transplant, or dietary intervention, such as the use of probiotics [172].…”

Section: Role Of Epigenetic Regulations In Sleep Under the Influence Of Other Lifestyle Factorsmentioning

confidence: 99%

Epigenetics of Sleep Disruption

Gazerani¹

2020

neurobiology

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Sleep plays an important role in maintaining brain function, memory consolidation, hormonal balance, immune system function, growth, and repair. The physiological and psychological effects of disruptions in sleep highlight its importance in human health and wellness. Epigenetic roles are proposed in sleep, and circadian regulation, but only a limited number of studies have determined the mechanism that underlies the epigenetics of environmental factors interacting with the sleep, particularly the ones related to sleep disruption. Therefore, studying epigenetics of sleep and sleep disorders can help elucidate the way these factors promote or inhibit sleep disorders, potentially guiding the development of precision medicines or preventive strategies. However, before discovering useful epigenetic-based interventions for sleep disorders, we need to overcome many challenges. As a relatively new field, there are unmet needs that call for further investigation of epigenetic mechanisms underlying sleep disruption. This review focuses on the current status of epigenetic mechanisms in sleep disruption (e.g., sleep deprivation and circadian dysregulation), which highlights a great potential of both animal and human studies to explain the disturbances in sleep, associated consequences, and novel therapeutic potentials. Translating the epigenetic research in sleep disturbances can eventually lead to better diagnosis, prognosis, prevention, and therapy in the clinics.

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<b><i>Lifestyle Genomics</i></b>: Addressing the Multifactorial Nature of Personalized Health

Cited by 8 publications

References 70 publications

Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines

Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines

Gene-Centric Database Reveals Environmental and Lifestyle Relationships for Potential Risk Modification and Prevention

Epigenetics of Sleep Disruption

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