&lt;b&gt;&lt;i&gt;SMARCE1&lt;/i&gt;&lt;/b&gt; Promotes Chicken Embryonic&lt;b&gt; &lt;/b&gt;Gonad Development by Regulating&lt;b&gt;&lt;i&gt; ER&lt;/i&gt;&lt;/b&gt;α and &lt;b&gt;&lt;i&gt;AR &lt;/i&gt;&lt;/b&gt;Expression

Gong, Pan; Yang, Yu; Liu, Wanjun; Feng, Yanping; Li, S; Peng, Xiuli; Gong, Yanzhang

doi:10.1159/000338471

Cited by 6 publications

(3 citation statements)

References 90 publications

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“…Other studies are required to assess whether BAF57 has similar functions in vivo , during normal development or physiology of the reproductive organs. One study with this aim was reported in which BAF57 was overexpressed in chicken embryos . The study revealed that exogenous BAF57 was able to upregulate ERα together with other gonad‐related genes, whereas it significantly downregulated AR expression.…”

Section: Cellular Functionsmentioning

confidence: 99%

The developmental and pathogenic roles of BAF57, a special subunit of the BAF chromatin‐remodeling complex

Lomelı́

Castillo-Robles

2016

FEBS Letters

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Edited by Claus AzzalinMammalian SWI/SNF or BAF chromatin-remodeling complexes are polymorphic assemblies of homologous subunit families that remodel nucleosomes. BAF57 is a subunit of the BAF complexes; it is encoded only in higher eukaryotes and is present in all mammalian assemblies. Its main structural feature is a high-mobility group domain, the DNA-binding properties of which suggest that BAF57 may play topological roles as the BAF complex enters or exits the nucleosome. BAF57 displays specific interactions with a number of proteins outside the BAF complex. Through these interactions, it can accomplish specific functions. In the embryo, BAF57 is responsible for the silencing of the CD4 gene during T-cell differentiation, and during the repression of neuronal genes in non-neuronal cells, BAF57 interacts with the transcriptional corepressor, Co-REST, and facilitates repression. Extensive work has demonstrated a specific role of BAF57 in regulating the interactions between BAF and nuclear hormone receptors. Despite its involvement in oncogenic pathways, new generation sequencing studies do not support a prominent role for BAF57 in the initiation of cancer. On the other hand, evidence has emerged to support a role for BAF57 as a metastasis factor, a prognosis marker and a therapeutic target. In humans, BAF57 is associated with disease, as mutations in this gene predispose to important congenital disorders, including menigioma disease or the Coffin-Siris syndrome. In this article, we present an exhaustive analysis of the BAF57 molecular and biochemical properties, cellular functions, loss-of-function phenotypes in living organisms and pathological manifestations in cases of human mutations.Keywords: Brg1/Brm-associated factors; cancer; chromatin remodeling; development; epigenetics; high-mobility group; inherited disorder; nuclear receptors The SWItch/sucrose nonfermentable (SWI/SNF) chromatin-remodeling complex facilitates the binding of transcriptional factors to nucleosomal templates through an ATP-dependent nucleosome disruption activity. First discovered in yeast, SWI/SNF was initially thought to have a transcription activating role

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Section: Cellular Functionsmentioning

confidence: 99%

The developmental and pathogenic roles of BAF57, a special subunit of the BAF chromatin‐remodeling complex

Lomelı́

Castillo-Robles

2016

FEBS Letters

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“…In addition, FOXL2 and P450arom are known to play key roles in ovarian differentiation and function in birds and mammals [Chue and Smith, 2011;Gong et al, 2012]. Whatever the role of MHM, it is unlikely to be related to morphological changes per se as there is no difference in methylation patterns between left and right female gonads.…”

Section: Discussionmentioning

confidence: 99%

A Window of MHM Demethylation Correlates with Key Events in Gonadal Differentiation in the Chicken

Yang

Deng²,

Zheng³

et al. 2016

Sex Dev

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The MHM (male hypermethylated) region on the chicken Z chromosome is of interest in terms of sex determination both because hypermethylation of the promoter in males results in female-specific expression, and in females the non-coding transcripts accumulate in the region of a locus that encodes a key candidate gene for testis differentiation in birds - DMRT1. However, it has yet to be established whether MHM plays a role in either sex determination or gonadal development in chicken. Here, we sought to establish the MHM methylation pattern during chicken gonadal development and determine how this pattern correlates with the expression profiles of genes involved in sex determination and gonadal differentiation. As expected, we found that MHM methylation levels were higher in male than in female gonads at most stages of development. We also showed that there was no significant difference in the methylation patterns between the right and left gonad and that the pattern of methylation in female gonads was not affected by sex reversal. However, we did find an unexpected window where MHM promoter methylation levels were very low in both males and females. This developmental window coincided with a stage of gonad development where there is a dramatic increase in expression of key testis genes in males and of key ovary genes in females. The current study raises the possibility that the non-coding RNA transcripts of MHM may affect testis and ovary differentiation by influencing sex-specific gene expression.

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“…The male leg muscle of E13.5 chicken embryos were isolated and fixed in 4% paraformaldehyde for at least 48 h at 4 °C and then 4-mm paraffin sections prepared for FISH. DNA was extracted from the mesentery of embryos at E7 for sexing by PCR [ 29 ] and the gender of each embryo at E10-D1 was clearly distinguished by its gonad morphology.…”

Section: Methodsmentioning

confidence: 99%

Male-Biased gga-miR-2954 Regulates Myoblast Proliferation and Differentiation of Chicken Embryos by Targeting YY1

Dong

Cheng

Qiao

et al. 2021

Genes

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Previous studies have shown that gga-miR-2954 was highly expressed in the gonads and other tissues of male chickens, including muscle tissue. Yin Yang1 (YY1), which has functions in mammalian skeletal muscle development, and was predicted to be a target gene of gga-miR-2954. The purpose of this study was to investigate whether gga-miR-2954 plays a role in skeletal muscle development by targeting YY1, and evaluate its function in the sexual dimorphism development of chicken muscle. Here, all the temporal and spatial expression profiles in chicken embryonic muscles showed that gga-miR-2954 is highly expressed in males and mainly localized in cytoplasm. Gga-miR-2954 exhibited upregulated expression of in vitro myoblast differentiation stages. Next, through the overexpression and loss-of-function experiments performed in chicken primary myoblasts, we found that gga-miR-2954 inhibited myoblast proliferation but promoted differentiation. During myogenesis, gga-miR-2954 could suppress the expression of YY1, which promoted myoblast proliferation and inhibited the process of myoblast cell differentiation into multinucleated myotubes. Overall, these findings reveal a novel role of gga-miR-2954 in skeletal muscle development through its function of the myoblast proliferation and differentiation by suppressing the expression of YY1. Moreover, gga-miR-2954 may contribute to the sex difference in chicken muscle development.

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<b><i>SMARCE1</i></b> Promotes Chicken Embryonic<b> </b>Gonad Development by Regulating<b><i> ER</i></b>α and <b><i>AR </i></b>Expression

Cited by 6 publications

References 90 publications

The developmental and pathogenic roles of BAF57, a special subunit of the BAF chromatin‐remodeling complex

The developmental and pathogenic roles of BAF57, a special subunit of the BAF chromatin‐remodeling complex

A Window of MHM Demethylation Correlates with Key Events in Gonadal Differentiation in the Chicken

Male-Biased gga-miR-2954 Regulates Myoblast Proliferation and Differentiation of Chicken Embryos by Targeting YY1

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