&lt;b&gt;MULTIPLE FORMS OF GLYCYLPROLYL DIPEPTIDYL AMINOPEPTIDASE (DIPEPTIDYL PEPTIDASE IV) IN HUMAN SERA FROM PATIENTS WITH &lt;/b&gt;&lt;b&gt;HEPATITIS &lt;/b&gt;

Kasahara, Y.; Fujii, Nobuyuki; Naka, Hajime; Nagatsu, Toshiharu

doi:10.2220/biomedres.3.265

Cited by 5 publications

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“…Over the last 15 years, altered serum DPPIV activity have been found in various diseases including systemic lupus erythematosus (SLE) (19)(20)(21)(22), different malignant processes (21,(23)(24)(25)(26)(27)(28)(29)(30), liver disease (21,23,24,(31)(32)(33) and osteoporosis (34). Serum DPPIV activity was proposed as a marker of cholestasis (35).…”

Section: Introductionmentioning

confidence: 99%

Reference Values for Plasma Dipeptidyl Peptidase IV Activity and Their Association with Other Laboratory Parameters

Durinx¹,

Neels²,

Auwera³

et al. 2001

Clinical Chemistry and Laboratory Medicine

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In blood, the exopeptidase dipeptidyl-peptidase IV (DPPIV; EC 3.4.14.5) is predominantly present in a soluble form in plasma/serum and as an activation antigen on the membrane of lymphocytes (CD26). It modifies some important biologically active peptides (neuropeptides, chemokines), and a regulatory role for DPPIV/CD26 in immune and endocrine processes has been demonstrated. The aim of this study was to determine reference values for plasma/serum DPPIV activity and to study the association of this activity with a series of biochemical and hematological parameters and baseline characteristics such as age, gender, blood pressure and body mass index. We studied 481 healthy subjects aged between 19 and 61 years. The group consisted of 213 men and 268 women equally divided between the different categories of age. Among the women, 127 were taking hormone therapy (contraception/hormone replacement) and 141 were not. A multiple regression model shows that DPPIV activity decreases significantly with age. The activity in women is slightly lower than in men. We observed an important association with liver, muscle and lipid metabolism-related parameters. In this model, no significant contribution of body mass index, blood pressure or hormone therapy could be stated.

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Section: Introductionmentioning

confidence: 99%

Reference Values for Plasma Dipeptidyl Peptidase IV Activity and Their Association with Other Laboratory Parameters

Durinx¹,

Neels²,

Auwera³

et al. 2001

Clinical Chemistry and Laboratory Medicine

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“…Mit allerdings teilweise sehr kleinen Fallzahlen wurde in den folgenden Jahren eine statistisch signifikante Veränderung der Serum/Plasma-D P l V-Aktivität bei Karzinomen der Leber (11,12,14,16,19,23,34), des Pankreas (11), der Lunge (2) und bei unterschiedlichen Leukämieformen von verschiedenen Arbeitskreisen (3,6,(23)(24)(25)29) beschrieben. DP IV-Aktivitätserhöhungen werden innerhalb der malignen Erkrankungen nur bei denen der Leber beobachtet.…”

Section: Benigne Lebererkrankungunclassified

“…Elektrophoretische und Untersuchungen mittels lonenaustauschchromatographie (16,23) belegen, daß beim Gesunden die DP IV-Aktivität des Plasmas/Serums zum großen Teil mit der multiplen Form der Lymphozyten-DP IV übereinstimmt. Bei Patienten mit Alterationen der Leber, bei denen DP l V-Aktivitätserhöhungen des Serums festgestellt werden, läßt sich eine DP l V-Fraktion im Serum nachweisen, die mit der aus Leberhomogenaten identisch ist.…”

Section: ) Mögliche Ursachen Der Serum-d P Iv-aktivitätsveränderungenunclassified

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Die Bedeutung der Aktivitätsbestimmung des Enzyms Dipeptidyl-Peptidase IV (DP IV) im klinischen Laboratorium

Küllertz¹

1988

LaboratoriumsMedizin

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The proteolytic enzyme dipeptidyl-peptidase IV (DP IV) exists in various tissues and body fluids of human organism. In lymphatic tissues, peripheral blood cells and bone marrow, DP IV occurs only in lymphocytes and predominately on the or CD-4 subset Some hints exist for the involvement in the degradation of proline-containing biological active peptides e. g. substance P, ß-casomorphine, endogenous interleukin-2. The source of the serum-DP IV is not yet clear, but the Chromatographie pattern of the serum activity suggested, that liver and lymphocytes are strongly involved in the enzyme excretion. There is a high activity of DP IV in human serum if hepatic disorder occur. On the other haod in the patients with cancer, acute lymphocytic leukemia, Hodgkin's disease, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, multiple myeloma and pregnancy the activity of the enzyme is Iow. No influence could be observed in the case of hypertension or benigne neoplasm. If the activity stage of rheumatoid arthritis (clinical and paraclinical picture) is on the increase, the DP IV-activity in serum and synovial fluid decreases. . Characterizing cerebral diseases, there is a surprisingly high activity of the enzyme in the cerebrospinal fluid of patients with bacterial meningitis. Furthermore, all bacteria which could be isolated from cerebrospinal fluid show high activities of post-proline cleaving hydrolases.Einleitung Dipeptidyl-Peptidase (lV)-Aktivität läßt sich im humanen Organismus sowohl fest strukturgebunden an Zellmembranen zahlreicher Organe und Gewebe als auch in gelöster Form in allen Körperflüssigkeiten mit unterschiedlichen Aktivitäten nachweisen. Im Vergleich zu anderen Peptidasen, die zumeist ein breites Spektrum von Peptid-substraten katalysieren, besitzt DP IV eine große Substratspezifität (22). Erste Untersuchungen über die Verwendbarkeit der DP IV-Aktivitätsbestimmung als diagnostisches Hilfsmittel wurden schon kurz nach Entdeckung dieser Katalysespezifität (13) durchgeführt. Angaben zur diagnostischen Relevanz dieser Enzymaktivität im Blutplasma bzw. Serum, Urin, Liquor cerebrospinalis, Seminalplasma und Sy-Lab.med.12:123(1988) 123Brought to you by |

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“…Bei Lebererkrankungen, die mit Cholestase einhergehen, werden Dipeptidyl-Peptidase IV-Aktivitätserhöhungen bis zum 3-fachen des Referenzbereiches festgestellt (17)(18)(19)(20). Die von Fuyamada et al (21) nachgewiesene Zunahme der Dipeptidyl-Peptidase IV-Aktivität in Seren von Hypertonikern konnte von anderen Arbeitskreisen nicht bestätigt werden (22,23).…”

Section: Seither Konnten Von Verschiedenen Arbeitsgruppenunclassified

Review

1986

Clinical Chemistry and Laboratory Medicine

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<b>MULTIPLE FORMS OF GLYCYLPROLYL DIPEPTIDYL AMINOPEPTIDASE (DIPEPTIDYL PEPTIDASE IV) IN HUMAN SERA FROM PATIENTS WITH </b><b>HEPATITIS </b>

Cited by 5 publications

References 1 publication

Reference Values for Plasma Dipeptidyl Peptidase IV Activity and Their Association with Other Laboratory Parameters

Reference Values for Plasma Dipeptidyl Peptidase IV Activity and Their Association with Other Laboratory Parameters

Die Bedeutung der Aktivitätsbestimmung des Enzyms Dipeptidyl-Peptidase IV (DP IV) im klinischen Laboratorium

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