&lt;b&gt;STIMULATORY EFFECT OF VASOACTIVE INTESTINAL PEPTIDE (VIP) ON THE GROWTH AND STEROIDOGENIC CAPACITY OF RAT ADRENAL ZONA &lt;/b&gt;&lt;b&gt;GLOMERULOSA &lt;/b&gt;

Mazzocchi, Giuseppina; Robba, Claudia; Malendowicz, Ludwik K.; Nussdorfer, Gastone G.

doi:10.2220/biomedres.8.19

Cited by 20 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, Gallo-Payet et al (1987) and Bornstein et al (1994) referred to the relevant paracrine mechanisms within the adrenal cortex, and several neuropeptides were identified in the gland (Malendowicz, 1993). Concerning adrenal growth, VIP and neuropeptide Y chronically stimulate the growth of zona glomerulosa and aldosterone secretion (Mazzocchi et al, 1987;Rebuffat et al, 19881, but such an effect was observed only when the architecture of the zona glomerulosa was preserved. The effect from VIP seemed to be mediated by local release of adrenaline (Hinson et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

Modulation of autotransplanted adrenal gland by endothelin‐1: A morphological and biochemical study

et al. 1996

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Modulation of autotransplanted adrenal gland by endothelin‐1: A morphological and biochemical study

et al. 1996

View full text Add to dashboard Cite

“…Other studies in rats however, suggest that VIP is only effective in stimulating aldosterone secretion in the presence of ACTH (66). Further studies showed that long-term (7-day) administration of VIP to intact rats stimulates the growth and steroidogenic capacity of the zona glomerulosa, with no apparent effect on corticosterone secretion and the zona fasciculata (67).…”

Section: The Innervation Of the Adrenal Cortexmentioning

confidence: 93%

The Neuroendocrinology of the Adrenal Cortex

Vinson

Hinson

Tóth

1994

J Neuroendocrinology

108

View full text Add to dashboard Cite

Although until relatively recently assumed to be devoid of innervation, there is now ample proof that the adrenal cortex receives specific neurones of several types. A general interpretation of their roles in the regulation of adrenocortical function has not been forthcoming, probably because of the variety of the different experimental approaches which have been used, and the heterogeneous observations which have been made. We here summarize the evidence which is available, and offer the view that neural inputs may provide fine tuning of the responses to systemic factors such as ACTH, through direct actions on specific adrenocortical cells. However, neural regulation also provides an integrative function, through actions on the flow of blood through the gland, which itself exerts a powerful influence on adrenocortical function.

show abstract

“…Some of the neuropeptides identified in the cortex have been shown to exert specific effects on adrenocortical function: vasoactive intestinal peptide stimulates aldosterone secretion in vitro (Cunningham & Holzwarth, 1988), potentiates the effects of ACTH in vivo (Bloom, Edwards & Jones, 1987a; and also stimu¬ lates growth of the zona glomerulosa (Mazzocchi, Robba, Malendowicz & Nussdorfer, 1987); chronic administration of an analogue of methionine-enkephalin stimulates both inner zone and zona glomeru¬ losa function (Robba, Mazzocchi & Nussdorfer, 1986a,Z>); and neuropeptide Y stimulates aldosterone secretion in vivo and chronically causes growth of the zona glomerulosa (Rebuffat, Malendowicz, Belloni et al 1988). …”

mentioning

confidence: 99%