2016
DOI: 10.2220/biomedres.37.117
|View full text |Cite
|
Sign up to set email alerts
|

<b>Tensile stress stimulates the expression of osteogenic cytokines/growth factors and matricellular proteins in the mouse cranial suture at the site of osteoblast differ</b><b>entiation </b>

Abstract: Mechanical stress promotes osteoblast proliferation and differentiation from mesenchymal stem cells (MSCs). Although numerous growth factors and cytokines are known to regulate this process, information regarding the differentiation of mechanically stimulated osteoblasts from MSCs in in vivo microenvironment is limited. To determine the significant factors involved in this process, we performed a global analysis of differentially expressed genes, in response to tensile stress, in the mouse cranial suture where… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
6
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 14 publications
(6 citation statements)
references
References 54 publications
0
6
0
Order By: Relevance
“…Galectin-9 expression is also upregulated in MSCs undergoing stress-induced osteoblast differentiation. A 1.6-fold increase in galectin-9 mRNA was reported at 3 h upon tensile stress applied to parietal mouse bones along with bone morphogenetic proteins, Wnt, epithelial growth factor signaling factors, and matricellular proteins [ 60 ]. Similarly, the expression of galectin-9 was increased in human MSCs cells during TGFβ3-induced differentiation into chondrocytes and recombinant galectin-9 at a concentration of 1–100 nM enhanced this differentiation through up-regulation of Smad2 signaling [ 41 ].…”
Section: Galectin-9mentioning
confidence: 99%
“…Galectin-9 expression is also upregulated in MSCs undergoing stress-induced osteoblast differentiation. A 1.6-fold increase in galectin-9 mRNA was reported at 3 h upon tensile stress applied to parietal mouse bones along with bone morphogenetic proteins, Wnt, epithelial growth factor signaling factors, and matricellular proteins [ 60 ]. Similarly, the expression of galectin-9 was increased in human MSCs cells during TGFβ3-induced differentiation into chondrocytes and recombinant galectin-9 at a concentration of 1–100 nM enhanced this differentiation through up-regulation of Smad2 signaling [ 41 ].…”
Section: Galectin-9mentioning
confidence: 99%
“…The organ culture system with stretching stimulus using coiled springs has been described previously. 18,19 Briefly, the left and right parietal bones of 4-day-old ddY mice were excised, with presenting the intact sagittal suture. In the stretched experimental groups (EXP), these parietal bones were then affixed to an activated coiled spring, creating a continuous stretching stimulus in the direction of enlarging the suture.…”
Section: Methodsmentioning
confidence: 99%
“…Turning to the cranium, pressure gradients caused by brain enlargement deform the ECM of the dura mater, creating tensile forces that are then transmitted to the bones and sutures of the cranium (Moazen et al 2016; Marghoub et al 2018). This increase in suture tension stimulates several biochemical signaling processes (e.g., growth factor and BMP signaling; Ikegame et al 2016) in the suture mesenchyme that lead to cell proliferation, differentiation, and suture fusion. Indeed, abnormally reduced intracranial pressure and the associated reduction in cranial-ECM tension can result in premature suture fusion (craniosynostosis) and resulting microcephaly (Park and Yoon 2017).…”
Section: Mechanical Regulation Of Craniofacial Developmentmentioning
confidence: 99%