&lt;![CDATA[Myocardial metabolism after hypothermic retrograde continuous blood cardioplegia with anterograde warm cardioplegic induction]]&gt;

Sobrosa, Claudio G.; Jansson, Eva; Kaijser, L.; Bomfim, Vollmer

doi:10.1590/s1678-97412005000400010

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…However, we are not able to explain how the myocardium may use lactate without a corresponding increase in oxygen utilization. Sobrosa et al ( 10 ) found positive gradients between arterial blood lactate and blood from the coronary sinus, concomitantly with a minimum difference between the SO 2 of arterial blood and the blood from the coronary sinus in patients undergoing CABG with cardiopulmonary bypass at the time of reperfusion.…”

Section: Discussionmentioning

confidence: 98%

Oxygen saturation and lactate concentration gradient from the right atrium to the pulmonary artery in the immediate postoperative following cardiac surgery with extracorporeal circulation

Pendino¹,

Hess²,

Beltrame³

et al. 2017

Revista Brasileira De Terapia Intensiva

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ObjectiveThis prospective study aimed to characterize the changes in blood lactate concentration and blood oxygen saturation in patients during the immediate postoperative period of cardiac surgery with extracorporeal circulation.MethodsBlood samples were collected from 35 patients in a rapid and random order from the arterial line and from the proximal and distal port of a pulmonary artery catheter.ResultsThe results showed no statistically significant differences between the blood oxygen saturation in the right atrium (72% ± 0.11%) and the blood oxygen saturation in the pulmonary artery (71% ± 0.08%). The blood lactate concentration in the right atrium was 1.7mmol/L ± 0.5mmol/L, and the blood lactate concentration in the pulmonary artery was 1.6mmol/L ± 0.5mmol/L (p < 0.0005).ConclusionThe difference between the blood lactate concentration in the right atrium and the blood lactate concentration in the pulmonary artery might be a consequence of the low blood lactate concentration in the blood from the coronary sinus, as it constitutes an important substrate for the myocardium during this period. The lack of differences between the blood oxygen saturation in the right atrium and the percentage of blood oxygen saturation in the pulmonary artery suggests a lower oxygen extraction by the myocardium given a lower oxygen consumption.

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Section: Discussionmentioning

confidence: 98%

Oxygen saturation and lactate concentration gradient from the right atrium to the pulmonary artery in the immediate postoperative following cardiac surgery with extracorporeal circulation

Pendino¹,

Hess²,

Beltrame³

et al. 2017

Revista Brasileira De Terapia Intensiva

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“…The main principles of myocardial protection are reduction of metabolic activity by hypothermia and therapeutic arrest of the electrical activity and contractile apparatus of the myocytes by administering cardioplegic solution ( e.g. , depolarization of the membrane potential by high potassium blood cardioplegia [ 1 - 3 ] .…”

Section: Introductionmentioning

confidence: 99%

Single-Dose Lignocaine-Based Blood Cardioplegia in Single Valve Replacement Patients

Ramani¹,

Malhotra²,

Wadhwa³

et al. 2017

Braz J Cardiovasc Surg

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Objective Myocardial protection is the most important in cardiac surgery. We compared our modified single-dose long-acting lignocaine-based blood cardioplegia with short-acting St Thomas 1 blood cardioplegia in patients undergoing single valve replacement.MethodsA total of 110 patients who underwent single (aortic or mitral) valve replacement surgery were enrolled. Patients were divided in two groups based on the cardioplegia solution used. In group 1 (56 patients), long-acting lignocaine based-blood cardioplegia solution was administered as a single dose while in group 2 (54 patients), standard St Thomas IB (short-acting blood-based cardioplegia solution) was administered and repeated every 20 minutes. All the patients were compared for preoperative baseline parameters, intraoperative and all the postoperative parameters.ResultsWe did not find any statistically significant difference in preoperative baseline parameters. Cardiopulmonary bypass time were 73.8±16.5 and 76.4±16.9 minutes (P=0.43) and cross clamp time were 58.9±10.3 and 66.3±11.2 minutes (P=0.23) in group 1 and group 2, respectively. Mean of maximum inotrope score was 6.3±2.52 and 6.1±2.13 (P=0.65) in group 1 and group 2, respectively. We also did not find any statistically significant difference in creatine-phosphokinase-MB (CPK-MB), Troponin-I levels, lactate level and cardiac functions postoperatively.Conclusion This study proves the safety and efficacy of long-acting lignocaine-based single-dose blood cardioplegia compared to the standard short-acting multi-dose blood cardioplegia in patients requiring the single valve replacement. Further studies need to be undertaken to establish this non-inferiority in situations of complex cardiac procedures especially in compromised patients.

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<![CDATA[Myocardial metabolism after hypothermic retrograde continuous blood cardioplegia with anterograde warm cardioplegic induction]]>

Abstract: Metabolismo miocárdico após cardioplegia sangüínea hipotérmica retrógrada contínua com indução anterógrada normotérmica

Cited by 2 publications

References 16 publications

Oxygen saturation and lactate concentration gradient from the right atrium to the pulmonary artery in the immediate postoperative following cardiac surgery with extracorporeal circulation

Oxygen saturation and lactate concentration gradient from the right atrium to the pulmonary artery in the immediate postoperative following cardiac surgery with extracorporeal circulation

Single-Dose Lignocaine-Based Blood Cardioplegia in Single Valve Replacement Patients

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