&lt;div&gt;Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway&lt;/div&gt;

Qin, Yue; Li, Suning; Zhao, Gan; Fu, Xuanhao; Xie, Xueping; Huang, Yiyi; Cheng, Xiaojing; Wei, Jinbin; Liu, Huagang; Lai, Zhiyong

doi:10.2147/ijn.s123839

Cited by 34 publications

(10 citation statements)

References 67 publications

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“…Some studies demonstrated that CNTs, even in low concentrations, are able to trigger inflammation in the respiratory system of animals [168]. In addition to inflammation, it was revealed that CNTs are also capable of inducing the modulation of proliferation of lung cells as a result of direct injury [169], fibrosis [170], DNA damage [171], and lung cancer [172,173].…”

Section: Toxicity Studies Of Carbon Nanotubesmentioning

confidence: 99%

The Advances in Biomedical Applications of Carbon Nanotubes

Saliev

2019

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Unique chemical, physical, and biological features of carbon nanotubes make them an ideal candidate for myriad applications in industry and biomedicine. Carbon nanotubes have excellent electrical and thermal conductivity, high biocompatibility, flexibility, resistance to corrosion, nano-size, and a high surface area, which can be tailored and functionalized on demand. This review discusses the progress and main fields of bio-medical applications of carbon nanotubes based on recently-published reports. It encompasses the synthesis of carbon nanotubes and their application for bio-sensing, cancer treatment, hyperthermia induction, antibacterial therapy, and tissue engineering. Other areas of carbon nanotube applications were out of the scope of this review. Special attention has been paid to the problem of the toxicity of carbon nanotubes.

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Section: Toxicity Studies Of Carbon Nanotubesmentioning

confidence: 99%

The Advances in Biomedical Applications of Carbon Nanotubes

Saliev

2019

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“…Indeed, CNTs induce adverse effects, particularly on the respiratory tract, which constitutes the main route for penetration of these nanomaterials. They cause inflammatory, immunologic and fibrogenic effects in rodent lungs (Duke et al, 2017;Qin et al, 2017). Furthermore, key events shown on a cellular level, with NR8383 cells reveal that CNTs play a vital role in cell growth inhibition, production of reactive oxygen species (Fujita et al, 2015) and decrease of the mitochondrial membrane potential (Pulskamp, Diabaté, & Krug, 2007).…”

mentioning

confidence: 99%

Single wall and multiwall carbon nanotubes induce different toxicological responses in rat alveolar macrophages

Nahle

Safar

Grandemange

et al. 2019

J of Applied Toxicology

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Human exposure to airborne carbon nanotubes (CNT) is increasing because of their applications in different sectors; therefore, they constitute a biological hazard. Consequently, developing studies on CNT toxicity become a necessity. CNTs can have different properties in term of length, size and charge. Here, we compared the cellular effect of multiwall (MWCNTs) and single wall CNTs (SWCNTs). MWCNTs consist of multiple layers of graphene, while SWCNTs are monolayers. The effects of MWCNTs and SWCNTs were evaluated by the water‐soluble tetrazolium salt cell proliferation assay on NR8383 cells, rat alveolar macrophage cell line (NR8383). After 24 hours of exposure, MWCNTs showed higher toxicity (50% inhibitory concentration [IC 50 ] = 3.2 cm 2 /cm 2 ) than SWCNTs (IC 50 = 44 cm 2 /cm 2 ). Only SWCNTs have induced NR8383 cells apoptosis as assayed by flow cytometry using the annexin V/IP staining test. The expression of genes involved in oxidative burst ( Ncf1 ), inflammation ( Nfκb , Tnf‐α , Il‐6 and Il‐1β ), mitochondrial damage ( Opa ) and apoptotic balance ( Pdcd4 , Bcl‐2 and Casp‐8 ) was determined. We found that MWCNT exposure predominantly induce inflammation, while SWCNTs induce apoptosis and impaired mitochondrial function. Our results clearly suggest that MWCNTs are ideal candidates for acute inflammation induction. In vivo studies are required to confirm this hypothesis. However, we conclude that toxicity of CNTs is dependent on their physical and chemical characteristics.

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“…In spite of their beneficial role in various diseases, a study reported that the repeated and long-term administration of carboxylated SWNTsintravenously results in the persistent accumulation in the lungs, can cause the embolization of lung capillaries, the formation of granuloma, and can induce the NF–kappaB pathway that leads to pulmonary fibrosis. Additionally, pro-fibrotic growth factors (transforming growth factor-beta 1), pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1 beta), fibrotic markers(type-III collagens, matrix metalloproteinase-2, type-I collagen and metalloproteinase-2), and a tissue inhibitor were reported as having high post-exposure expressions after the intravenous administration of c-SWNTs, suggesting that cumulative and chronic toxicity to organs because of nanomaterials should be analyzed while administering intravenously [ 64 ]. In a study, it was reported that carboxyl group-functionalized multi-walled carbon nanotubes effectively enhanced the differentiation and mineralization of mammalian cementoblaststhrough interactions with the TGF-β/Smad pathway [ 65 ].…”

Section: Types Of Nanoparticlesmentioning

confidence: 99%

Broad-Spectrum Theranostics and Biomedical Application of Functionalized Nanomaterials

Alshamrani

2022

Polymers

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Nanotechnology is an important branch of science in therapies known as “nanomedicine” and is the junction of various fields such as material science, chemistry, biology, physics, and optics. Nanomaterials are in the range between 1 and 100 nm in size and provide a large surface area to volume ratio; thus, they can be used for various diseases, including cardiovascular diseases, cancer, bacterial infections, and diabetes. Nanoparticles play a crucial role in therapy as they can enhance the accumulation and release of pharmacological agents, improve targeted delivery and ultimately decrease the intensity of drug side effects. In this review, we discussthe types of nanomaterials that have various biomedical applications. Biomolecules that are often conjugated with nanoparticles are proteins, peptides, DNA, and lipids, which can enhance biocompatibility, stability, and solubility. In this review, we focus on bioconjugation and nanoparticles and also discuss different types of nanoparticles including micelles, liposomes, carbon nanotubes, nanospheres, dendrimers, quantum dots, and metallic nanoparticles and their crucial role in various diseases and clinical applications. Additionally, we review the use of nanomaterials for bio-imaging, drug delivery, biosensing tissue engineering, medical devices, and immunoassays. Understandingthe characteristics and properties of nanoparticles and their interactions with the biological system can help us to develop novel strategies for the treatment, prevention, and diagnosis of many diseases including cancer, pulmonary diseases, etc. In this present review, the importance of various kinds of nanoparticles and their biomedical applications are discussed in much detail.

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<div>Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway</div>

Cited by 34 publications

References 67 publications

The Advances in Biomedical Applications of Carbon Nanotubes

The Advances in Biomedical Applications of Carbon Nanotubes

Single wall and multiwall carbon nanotubes induce different toxicological responses in rat alveolar macrophages

Broad-Spectrum Theranostics and Biomedical Application of Functionalized Nanomaterials

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