&lt;em&gt;ERCC1&lt;/em&gt; and &lt;em&gt;XRCC1&lt;/em&gt; but not &lt;em&gt;XPA&lt;/em&gt; single nucleotide polymorphisms correlate with response to chemotherapy in endometrial carcinoma

Chen, Liang; Liu, Meimei; Liu, Hui; Lü, Dan; Zhao, Xiaodan; Yang, Xuejing

doi:10.2147/ott.s110976

Cited by 12 publications

(8 citation statements)

References 28 publications

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“…The potential role of these polymorphisms in cancer development lies in the fact that these polymorphic gene variations alter the level of DNA repair proteins and also act as biomarker for chemotherapeutic response. (Chen et al, 2016;Peng et al, 2014) The XRCC1 and APE-1 DNA repair genes was selected for this case control study because of their important role in maintaining genomic integrity. The aim of this association study is to identify disease susceptible gene variants with Cervical cancer in the women of Uttar Pradesh (North India).…”

Section: Research Articlementioning

confidence: 99%

Association of DNA Repair Genes XRCC1 and APE-1 with the Risk of Cervical Cancer in North Indian population

Charles

Raza

Sharma

et al. 2020

Asian Pac J Cancer Prev

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Backgrounds: Cervical cancer (CC) is one of the leading cause of death in women worldwide, HPV infection is the major risk factor in the disease development, 0and however other risk factor such as chemical carcinogens, genetic susceptibility and altered immune system are also a cause of the disease progression. In the light of the above statement we studied the base excision repair pathway (BER). Methods: We identified and studied the association of Single Nucleotide polymorphisms in the DNA repair genes of XRCC1 ( Arg194Trp, Arg399G ,) and APE-1Asp/148Glu to the susceptibility of cervical cancer (CC) in North Indian population. In our study of cases (n=102). Controls (n=109) were recruited from among women without cervical abnormalities. Genotypes were determined by PCR-CTPP method, Taking DNA from peripheral blood in a case control study. Results: A positive association was observed between the polymorphisms of XRCC1 genes, that is, in codons 194 (P=0.03, odds ratio (OR) =2.39, 95% confidence interval (CI)=5.2–1.1), 280 (P=0.01, OR=4.1, 95% CI=11.5–1.3) and 399 (P=0.01, OR=3.4, 95% CI=8.6–1.3) while APE-1 genotype GG (p=0.03,odds ratio(OR)=0.2,95% confidence interval (CI)=0.97-0.004) we observed a statistically significant protective role in developing cervical cancer. Conclusion: Our results suggested that, XRCC1 gene is an important candidate gene for susceptibility to cervical cancer. Although the sample size was small, the present study indicate a statistical association between cervical cancer and XRCC1 SNPs . Future studies are needed that may provide a better understanding of the association between gene polymorphism and cervical carcinoma risk.

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Section: Research Articlementioning

confidence: 99%

Association of DNA Repair Genes XRCC1 and APE-1 with the Risk of Cervical Cancer in North Indian population

Charles

Raza

Sharma

et al. 2020

Asian Pac J Cancer Prev

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“…Chen et al indicates the patients carrying A/A + G/A genotypes in rs11615 of ERCC1 are at higher risk of endometrial carcinoma than those with G/G genotype. Homozygous G/G genotype in rs11615 of ERCC1 had a higher response rate of chemotherapy than patients with G/A + A/A genotype …”

Section: Discussionmentioning

confidence: 95%

Promoter polymorphisms of TOP2A and ERCC1 genes as predictive factors for chemotherapy in non‐small cell lung cancer patients

et al. 2019

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Background: Topoisomerase 2-alpha (TOP2A) is an enzyme that controls topologic changes in DNA during transcription and replication. ERCC1 is an enzyme that takes part in DNA repair processes. The purpose of this study was to assess the predictive role of particular single nucleotide polymorphisms (SNPs) in the promoter regions of TOP2A and ERCC1 genes in non-small cell lung cancer patients (NSCLC) treated with chemotherapy. Materials and methods: We enrolled 113 NSCLC patients treated in the first line with platinum-based chemotherapy. Effectiveness was available for 71 patients.

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“…Latest research discovered that five adjacent tag single-nucleotide polymorphisms at the 5’ end of ESR1 denoted lower risk of UCEC [35]. Significant correlation was established between single nucleotide polymorphisms of ERCC1 and chemosensitivity of UCEC in the study conducted by Chen L et al [36]. Elevated GRB2 was engaged in oncogenic events of UCEC triggered by insulin [37].…”

Section: Discussionmentioning

confidence: 99%

A novel alternative splicing-based prediction model for uteri corpus endometrial carcinoma

Chen

Pang

et al. 2019

Aging

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Alternative splicing (AS) is crucial a mechanism by which the complexity of mammalian and viral proteom increased overwhelmingly. There lacks systematic and comprehensive analysis of the prognostic significance of AS profiling landscape for uteri corpus endometrial carcinoma (UCEC). In this study, univariate and multivariate Cox regression analyses were conducted to identify candidate survival-associated AS events curated from SpliceSeq for the construction of prognostic index (PI) models. A correlation network between splicing factor-related AS events and significant survival-associated AS events were constructed using Cytoscape 3.5. As consequence, 28281 AS events from 8137 genes were detected from 506 UCEC patients, including 2630 survival-associated AS events. Kaplan Meier survival analysis revealed that six of the seven PI models (AD, AP, AT, ME, RI and ALL) exhibited good performance in stratifying the prognosis of low risk and high risk group (P<0.05). Among the six PI models, PI-AT performed best with an area under curves (AUC) value of 0.758 from time-dependent receiver operating characteristic. Correlation network implicated potential regulatory mechanism of AS events in UCEC. PI models based on survival-associated AS events for UCEC in this study showed preferable prognosis-predicting ability and may be promising prognostic indicators for UCEC patients.Summary: This is the first study to systematically investigate the prognostic value of AS in UCEC. Findings in the presents study supported the clinical potential of AS for UCEC and shed light on the potential AS-associated molecular basis of UCEC.

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<em>ERCC1</em> and <em>XRCC1</em> but not <em>XPA</em> single nucleotide polymorphisms correlate with response to chemotherapy in endometrial carcinoma

Cited by 12 publications

References 28 publications

Association of DNA Repair Genes XRCC1 and APE-1 with the Risk of Cervical Cancer in North Indian population

Association of DNA Repair Genes XRCC1 and APE-1 with the Risk of Cervical Cancer in North Indian population

Promoter polymorphisms of TOP2A and ERCC1 genes as predictive factors for chemotherapy in non‐small cell lung cancer patients

A novel alternative splicing-based prediction model for uteri corpus endometrial carcinoma

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