&lt;em&gt;Foxj2&lt;/em&gt; overexpression is associated with poor prognosis, progression, and metastasis in nasopharyngeal carcinoma

Shan, Ying; Chang, Tao; Shi, Si; Tang, Mingming; Bao, Lili; Li, Li; You, Bo; You, Yiwen

doi:10.2147/ott.s134915

Cited by 7 publications

(4 citation statements)

References 36 publications

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“…Nonetheless, Shan et al found that downregulation of FOXJ2 decreased the cell population in the S phase with enhanced G1 cycle arrest in nasopharyngeal carcinoma CNE-2 cells, and confirmed that patients with FOXJ2 overexpression had shorter survival in nasopharyngeal carcinoma. [ 15 ] In the current study, Kaplan–Meier survival analysis revealed that the high-FOXJ2 expression group showed longer median OS and PFS compared with the low-FOXJ2 expression group. Similar findings were obtained in the FIGO III-IV subgroup in stratified analysis.…”

Section: Discussionmentioning

confidence: 57%

Low FOXJ2 expression is associated with unfavorable postoperative prognosis of patients with epithelial ovarian cancer

Zhu

Liu³

et al. 2021

Medicine

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The forkhead box (FOX) family is a large and diverse group of transcription factors. Forkhead box J2 (FOXJ2) is a member of the FOX family that is aberrantly expressed in a variety of cancers. However, its role in epithelial ovarian cancer (EOC) remains elusive. The purpose of this study was to evaluate the prognostic value of FOXJ2 expression in patients with epithelial ovarian cancer. The current study retrospectively included 151 patients with EOC from January 2013 to September 2016. FOXJ2 expression was analyzed by immunohistochemistry based on tissue microarrays. Then, the prognostic value of FOXJ2 expression and clinical outcomes were evaluated by Kaplan–Meier and cox regression analysis. Low FOXJ2 expression was associated with high International Federation of Gynecology and Obstetrics (FIGO) stage. Kaplan–Meier curves showed that high FOXJ2 expression was associated with improved median overall survival (OS, 57.9 vs 31.9 months; P = .037) and longer median progression-free survival (PFS, 31.8 vs 18.1 months; P = .012). Univariate analysis demonstrated that FOXJ2 expression was significantly correlated with OS and PFS in patients with epithelial ovarian cancer. Multivariate analysis revealed FOXJ2 expression as an independent prognostic factor of progression-free survival of epithelial ovarian cancer patients. Low FOXJ2 expression is a novel adverse prognostic factor of clinical outcome in epithelial ovarian cancer.

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Section: Discussionmentioning

confidence: 57%

Low FOXJ2 expression is associated with unfavorable postoperative prognosis of patients with epithelial ovarian cancer

Zhu

Liu³

et al. 2021

Medicine

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“…FOXJ2 overexpression is associated with poor prognosis, progression, and metastasis in nasopharyngeal carcinoma [ 95 ]. FOXQ1, a member of the FOX family, is overexpressed in colorectal cancer, and it enhances tumorigenicity and tumor growth [ 96 ].…”

Section: Discussionmentioning

confidence: 99%

Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke

Hiwasa

Wang

Goto

et al. 2021

BMC Med

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Background Acute ischemic stroke (AIS) is a serious cause of mortality and disability. AIS is a serious cause of mortality and disability. Early diagnosis of atherosclerosis, which is the major cause of AIS, allows therapeutic intervention before the onset, leading to prevention of AIS. Methods Serological identification by cDNA expression cDNA libraries and the protein array method were used for the screening of antigens recognized by serum IgG antibodies in patients with atherosclerosis. Recombinant proteins or synthetic peptides derived from candidate antigens were used as antigens to compare serum IgG levels between healthy donors (HDs) and patients with atherosclerosis-related disease using the amplified luminescent proximity homogeneous assay-linked immunosorbent assay. Results The first screening using the protein array method identified death-inducer obliterator 1 (DIDO1), forkhead box J2 (FOXJ2), and cleavage and polyadenylation specificity factor (CPSF2) as the target antigens of serum IgG antibodies in patients with AIS. Then, we prepared various antigens including glutathione S-transferase-fused DIDO1 protein as well as peptides of the amino acids 297–311 of DIDO1, 426–440 of FOXJ2, and 607–621 of CPSF2 to examine serum antibody levels. Compared with HDs, a significant increase in antibody levels of the DIDO1 protein and peptide in patients with AIS, transient ischemic attack (TIA), and chronic kidney disease (CKD) but not in those with acute myocardial infarction and diabetes mellitus (DM). Serum anti-FOXJ2 antibody levels were elevated in most patients with atherosclerosis-related diseases, whereas serum anti-CPSF2 antibody levels were associated with AIS, TIA, and DM. Receiver operating characteristic curves showed that serum DIDO1 antibody levels were highly associated with CKD, and correlation analysis revealed that serum anti-FOXJ2 antibody levels were associated with hypertension. A prospective case–control study on ischemic stroke verified that the serum antibody levels of the DIDO1 protein and DIDO1, FOXJ2, and CPSF2 peptides showed significantly higher odds ratios with a risk of AIS in patients with the highest quartile than in those with the lowest quartile, indicating that these antibody markers are useful as risk factors for AIS. Conclusions Serum antibody levels of DIDO1, FOXJ2, and CPSF2 are useful in predicting the onset of atherosclerosis-related AIS caused by kidney failure, hypertension, and DM, respectively.

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“…The (FOX) family comprises a set of evolutionarily conserved transcriptional regulatory factors (Shan et al 2017) and is involved in the regulation of various biological processes; it can be classi ed into categories A-S based on sequence similarity in mammals (Bademci et al 2019;Zhang et al 2017). In addition, the Fox family regulates gene transcription.…”

Section: Introductionmentioning

confidence: 99%

FOXD subfamily genes serve as biomarkers and therapy targets in colorectal cancer

Chen,

Qiao,

Zhong

et al. 2023

Preprint

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Background: The forkhead box (FOX) family of proteins regulates gene transcription and expression. It regulates various biological processes, such as tumorigenesis and cell proliferation. FOXD, a subfamily of FOX, is associated with poor prognosis. However, the potential clinical value of FOXD subfamily members has not yet been elucidated. Methods: We used The Cancer Genome Atlas Project (TCGA), which was used to analyze the HTSeq-count data, clinical data, and single-nucleotide polymorphisms (SNPS). Furthermore, we used the DESEQ2 software to detect differentially expressed genes (DEGs). Batch survival analysis was performed using the survival and survminer packages in R to obtain genes with different expression levels. The intersection of the two results was used to identify the FOXD subfamily as the principal variable. Each gene was analyzed using RT-qPCR, western blotting, and immunohistochemistry. Functional enrichment analysis of FOXD subfamily-related DEGs was performed using the ClusterProfiler package. A protein network of FOXD subfamily-related DEGs was constructed using the STRING online database. We used CIBERSORT to determine the relationship between FOXD subfamily expression and immune cell infiltration. We established a survival analysis model to explore the clinical correlation between FOXD subfamily members and CRC. Results: In contrast to the normal tissue/cell line, FOXD1, FOXD2, FOXD3, and FOXD4 expression was higher. No FOXD1 mutations were detected. Moreover, FOXD2 was detected in both COAD and READ groups. FOXD3 and FOXD4 were onlymutated in COAD. Among the FOXD subfamily members, the AUC of FOXD3 was 0.949, indicating that FOXD3 has a high overall diagnostic accuracy for CRC. The results of the GSEA showed that the genes related to the FOXD subfamily were mainly related to the KEGG pathway, such as cytokine, cytokine, and ECM receptor interactions. Kaplan-Meier curves and nomograms showed that FOXD1, FOXD3, and FOXD4 were prognostically significant. Conclusions: We explored the correlation between the expression of the FOXD subfamily genes and the clinical and immunological characteristics of patients with CRC. The FOXD subfamily may serve as a diagnostic and prognostic biomarker for CRC and be used as an immunotherapy target in patients with CRC.

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<em>Foxj2</em> overexpression is associated with poor prognosis, progression, and metastasis in nasopharyngeal carcinoma

Cited by 7 publications

References 36 publications

Low FOXJ2 expression is associated with unfavorable postoperative prognosis of patients with epithelial ovarian cancer

Low FOXJ2 expression is associated with unfavorable postoperative prognosis of patients with epithelial ovarian cancer

Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke

FOXD subfamily genes serve as biomarkers and therapy targets in colorectal cancer

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