Solanum tuberosum is the most popular vegetable in people’s diets all over the world, and it’s considered a staple crop in many countries. It has immense potential to reduce food insecurity and prevent malnutrition in developing and developed countries because of its productivity, nutritional composition and unique biochemical features. However, a lack of information about the nutritional composition and biochemical properties of this tuber severely limits its use. Improved awareness of the biochemical and nutritional quality, utilization, and future economic importance of the crop has important implications for human food systems, nationally and internationally. This chapter presents a brief overview of key findings that led to our current knowledge of the biochemical and nutritional composition of the Solanum tuberosum tuber. The wide range of Solanum tuberosum varieties lays a great foundation for their industrial production and applications. The biochemical and nutritional composition of the Solanum tuberosum is summarized briefly.