<em>TERT-CLPTM1</em> locus polymorphism (rs401681) is associated with the prognosis of hepatocellular carcinoma

Abstract

Telomere length is associated with the development of hepatocellular carcinoma (HCC), and recent studies have focused on the genetic alteration or polymorphism in telomere-maintaining genes. We examined the clinicopathologic and prognostic value of rs401681 polymorphism, located in the TERT-CLPTM1L locus, in HCC. The relationship between rs401681 variants and telomere length was also analyzed in 156 HCC patients. The rs401681 polymorphism had the following genotype frequencies: C/C in 51.3% of the samples, C/T in 39.7%, and T/T in 9.0%. Telomeres in the tumor samples were 4.04-fold longer, on average, than the telomeres in matched normal samples (SD =1.32), and there were no differences in telomere length according to rs401681 polymorphism (p=0.802). Our results indicate that the rs401681 C allele was significantly associated with increased T and International Union for Cancer Control stages (p<0.01). Univariate and multivariate survival analyses showed that HCC with C allele had poorer prognosis (p<0.01). In conclusion, our findings suggest that rs401681 is a possible prognostic biomarker for HCC patients.

Targeted biologic inhibition of both tumor cell-intrinsic and intercellular CLPTM1L/CRR9-mediated chemotherapeutic drug resistance

“…proteinatlas.org). High expression of CLPTM1L and CLPTM1L expression-controlling polymorphisms 23 in tumors are associated with poor prognosis as described here and previously in 24 . The function of CLPTM1L is best understood in the context of antiapoptotic activity 2,[10][11][12]16,17,25 .…”

“…Data collected and annotated by the Human Protein Atlas also demonstrates high CLPTM1L expression in a variety of cancers including ovarian serous adenocarcinoma with no expression in normal ovary tissue or normal fallopian epithelium (available from http://www.proteinatlas.org ). High expression of CLPTM1L and CLPTM1L expression-controlling polymorphisms 23 in tumors are associated with poor prognosis as described here and previously in 24 . The function of CLPTM1L is best understood in the context of anti-apoptotic activity 2 , 10 – 12 , 16 , 17 , 25 .…”

Molecular Markers of Telomerase Complex for Patients with Pituitary Adenoma

“…The TERT gene is thought to be involved in an apoptotic response, and its level of expression affects the susceptibility of cancer cell lines to anticancer drugs. Whole-genome association studies have identified the TERT gene rs401681 as one of the most significant cancer-associated SNPs [ 29 ]. A study made by Ma and co-authors discusses the relationship between TERTp mutation and telomere length.…”

A new apatinib microcrystal formulation enhances the effect of radiofrequency ablation treatment on hepatocellular carcinoma

“…Currently, RFA is the prime treatment option for late-stage HCC, particularly for patients with cirrhosis or for those whose liver functional reserve precludes radiotherapy. 32 However, HCC can aggressively and rapidly recur after RFA. 32 To protect nontumor liver tissue, we cannot indefi-nitely increase the ablation temperature or power during RFA treatment.…”

“… 32 However, HCC can aggressively and rapidly recur after RFA. 32 To protect nontumor liver tissue, we cannot indefi-nitely increase the ablation temperature or power during RFA treatment. On the other hand, RFA may induce cellular stress and pathological changes in HCC cells.…”