&lt;i&gt;Cis&lt;/i&gt;- and &lt;i&gt;Trans&lt;/i&gt;-Isomeric Fatty Acids in Plasma Lipids of Newborn Infants and Their Mothers

Koletzko, Berthold; Müller, J. M.

doi:10.1159/000243188

Cited by 95 publications

(53 citation statements)

References 31 publications

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“…2). However, we do not observe as Koletzko [17,21] correlation between 18:1 t and TFAs (Table 2). TFAs represent on average 0.20% of the total fatty acids and the predominant isomer is the 18:1 (0.14%) isomers.…”

Section: Total Phospholipids In the Walls Of The Cord (N = 30)contrasting

confidence: 64%

“…As in the PLT of the arterial walls, negative correlations were found between 18:2 ct and arachidonic acid (AA) (r = 0.98, p < 0.001) and 20:4 n-6/18:2 n-6. There is therefore competition between the 18:2 ct and the EFAs and not a competition with the 18:1 trans as Koletzko [17] had found. Although the rate of 18: t is low, we think it is important to emphasize this correlation which could reflect the isomers of linoleic acid isomers to interfere with the conversion of the latter to 20:4 n-6, with potential repercussions on prostaglandin synthesis as discussed since PC is a reserve of 20:4 n-6, precursor of prostaglandins.…”

Section: Venous Walls Of the Cord (N = 7)mentioning

confidence: 88%

“…The content of TFAs in plasma phospholipids in healthy children was inversely correlated with AA, total n-6 long chain PUFAs and the ratio of arachidonic and linoleic acids, suggesting that TFAs interfere with linoleic acid metabolism [17]. Generally, these effects are not observed in adult subjects due to the fact that linoleic acid is more than sufficiently present in a normal diet, although production of some eicosanoids may be implicated.…”

Section: Sphingomyelinesmentioning

confidence: 99%

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Transfatty Acids (TFAs) in Cord Blood and Cord Tissue, in France

Billeaud¹,

Combe²,

Couëdelo³

et al. 2017

JFSE

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Abstract:Background: Recent studies suggest that dietary transfatty acids (TFAs) at relative high levels (i) increase the risk of coronary heart disease, (ii) inhibit the metabolism of linoleic acid and consequently increase requirement for essential fatty acids (EFAs). The aim of this prospective study was to estimate TFAs the placental transfer of TFAs to the foetus cord blood and cord tissues in France. Material: TFAs consumption was measured in 59 mother-foetus couples. TFAs transferring across the placenta were estimated by comparative measurement (Capillary Gaz Chromatography) of TFAs in mother's blood lipids (n = 59), cord blood lipids and cord tissue plasma lipids (n = 25) cord red blood tissue (n = 25) and umbilical vessels (n = 15). Results-Discussion: TFA deposition in cord blood is 0.58% slightly lower than mother level. TFAs incorporation in total lips of cord show selectivity of transfer with lower 18:1 t in cord blood and preferential transfer of diene 18:2 tc in cord blood. There is competition between the 18:2 tc in cholesterol esters (CE) with the linolenic acid and a negative correlation in PLT of arterial tissues with the 18:2 tc and C20:4 n-6 or arachidonic acid (AA), then there is the same competition in PE of venous tissue. But there is no effect on growth in our population of term newborn. Conclusions: Our results confirm the placental TFAs transfer, a better incorporation in the fetus CE; we demonstrated a selective transfer for the 18:2 9 trans 12 cis (18:2 tc) and a negative correlation (r = -0.76) with the linoleic acid and AA (r = 0.98). This competition, and the presence of these TFAs in cord tissues, even at a low TFAs consumption, remind us to be a potential risk for the fetus concerning EFA metabolism and growth.

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Section: Total Phospholipids In the Walls Of The Cord (N = 30)contrasting

confidence: 64%

Section: Venous Walls Of the Cord (N = 7)mentioning

confidence: 88%

Section: Sphingomyelinesmentioning

confidence: 99%

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Transfatty Acids (TFAs) in Cord Blood and Cord Tissue, in France

Billeaud¹,

Combe²,

Couëdelo³

et al. 2017

JFSE

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“…Other studies have also reported strong correlations between maternal and infant plasma trans fatty acid concentrations (Koletzko and Muller, 1990;Craig-Schmidt, 2001). To the best of our knowledge, no study has directly examined the influence or association between maternal trans fatty acid intake and early postpartum infant adiposity.…”

Section: Discussionmentioning

confidence: 90%

Dietary trans fatty acid intake and maternal and infant adiposity

2010

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Background/Objectives: The fatty acid composition in maternal diet and in breastmilk during lactation may be a factor in the development of childhood overweight later in life. To investigate the association between trans fatty acid and adiposity, 96 mother-infant pairs (exclusive breastfed; mixed fed; and formula fed) at 3 months postpartum were interviewed; body composition was measured onsite using the BOD POD and PEA POD for mothers and infants, respectively. Subjects/Methods: This was a cross-sectional study. Participants were recruited via convenience sampling from Athens-Clarke and surrounding counties of the state of Georgia. Data were analyzed using w 2 , analysis of variance and regression. Results: There were no significant differences in maternal percent body fat by feeding group (32.70, 33.70, and 35.73%, for exclusive, mixed and formula feeding, respectively). Exclusively breastfed infants had higher percent body fat (24.87%) compared with their mixed-fed counterparts (22.15%) but not formula-fed infants (23.93). Mothers who consumed at least 4.5 g of trans fatty acids/day were 5.8 times more likely to have body fat X30% than those consuming less (odds ratio ¼ 5.81; 95% confidence interval (CI), 1.05, 32.32), and their infants were over two times more likely (odds ratio ¼ 2.13; 95% CI, 0.75, 6.01) to have body fat X24%. Conclusions: Trans fatty acid content of the maternal diet may be associated with both maternal and infant body composition in the early postpartum period. More research is warranted regarding maternal dietary and breastmilk fatty acid composition and their effects on maternal and infant body composition and the development of childhood overweight later in life.

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“…Ces valeurs sont 3 fois plus faibles que celles rapportées par Koletzko [9] pour la population allemande. On observe chez le foetus les mêmes isomères que chez la mère, mais leurs proportions respectives sont différentes.…”

Section: Passage Des Isomères Trans De La Mère Au Foetusunclassified

Implication des acides gras trans alimentaires chez la femme enceinte

Billeaud

2000

OCL

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ARTICLE Matériels et méthodes Recueil des paramètres anthropométriques et échantillons de sang et de cordon ombilicalLes 90 parturientes, sans pathologie, ont donné naissance par césarienne programmée à 90 nouveau-nés à terme bien portants. Lors de la césarienne, au niveau du cordon ombilical ont été prélevés du sang veineux ainsi que 4 à 5 cm de cordon. Divers paramètres ont été relevés chez le bébé (poids, périmètre crânien...). Analyse du sang et des tissus du cordonAprès prélèvement, les échantillons biologiques ont été conservés à + 4 °C jusqu'à analyse. La veine et les deux artères du cordon ont été isolées, rincées avec une solution de NaCl (0,9 %), puis broyées dans un mélange chloroforme/méthanol (2/1 ; v/v) pour en extraire les lipides. Le plasma et les globules rouges du sang ombilical ont été séparés, les lipides en ont été extraits et analysés selon la méthode précédemment décrite [4]. Analyse statistiqueLes analyses statistiques ont été obtenues par le logiciel SPSS : statistiques descriptives, analyse de la distribution, analyses comparatives et corrélations. Le seuil de significativité retenu était de p < 0,05. Résultats et discussion Relation, chez la mère, entre consommation et teneur en AGT du plasmaComme cela a été démontré, la composition du tissu adipeux est un bon reflet de la consommation en AGT. Celle de notre population a été estimée à 3 g/j/personne, en moyenne. Durant la grossesse, il y a une augmentation de la lipolyse des triglycérides du tissu adipeux [5] qui contribue à l'élévation du taux de lipides circulants. La figure 1 montre la relation que nous avons mise en évidence entre les taux (en % des acides gras totaux) d'AGT présents dans le tissu et ceux présents dans le plasma Article disponible sur le site http://www.ocl-journal.org ou http://dx

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<i>Cis</i>- and <i>Trans</i>-Isomeric Fatty Acids in Plasma Lipids of Newborn Infants and Their Mothers

Cited by 95 publications

References 31 publications

Transfatty Acids (TFAs) in Cord Blood and Cord Tissue, in France

Transfatty Acids (TFAs) in Cord Blood and Cord Tissue, in France

Dietary trans fatty acid intake and maternal and infant adiposity

Implication des acides gras trans alimentaires chez la femme enceinte

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