&lt;i&gt;Dialister pneumosintes&lt;/i&gt; Bacteremia Caused by Dental Caries and Sinusitis

Kogure, Mariko; Suzuki, Hiromichi; Ishiguro, Shingo; Ueda, Atsuo; Nakahara, Takeshi; Tamai, Kazuya; Notake, Shigeyuki; Shiotani, Seiji; Umemoto, Takeshi; Morishima, Isamu; Ueno, Ei

doi:10.2169/internalmedicine.54.2904

Cited by 14 publications

(16 citation statements)

References 31 publications

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“…However, there was no evidence of descending transmission of infection from the orthodontic source. In this case, it was a hematogenous spread of infection from the dental abscess, and Dialister pneumosinte s bacteremia of periodontal origin has been documented in the literature [ 5 , 6 ]. A study of 135 systemically healthy dentistry patients revealed D. pneumosintes was the pathogenic organism in 83% of cases of severe periodontitis and 19% of cases of slight periodontitis [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Dialister pneumosintes Bacteremia-Associated Neck and Mediastinal Abscess

et al. 2021

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Patient: Female, 30-year-old Final Diagnosis: Dialister pneumosintes bacteraemia associated mediastinal and neck abscess Symptoms: Diarrhoea • fever • vomiting Medication: — Clinical Procedure: Incision and drainage Specialty: General and Internal Medicine Objective: Rare disease Background: Dialister pneumosintes is a suspected periodontal pathogen. It can affect different parts of the body either by hematogenous transmission or regional spread. Here, we report a case of 30-year-old previously healthy woman diagnosed with mediastinal and neck abscess caused by this pathogen. Case Report: A 30-year-old woman presented with a 1-day history of fever, vomiting, and diarrhea. She was on her last dose of a 2-week course of oral antibiotic for suspected dental abscess. On admission, parenteral broad-spectrum antibiotic was started for sepsis of unknown source. Because of intermittent spike of high temperature despite being on an antibiotic, cross-sectional imaging was performed, which revealed a superior mediastinal abscess with extension in the neck. She was referred to the ENT surgeon for incision and drainage of the collection. However, the procedure was complicated by injury to the right internal jugular vein. Her postoperative period was also convoluted with the development of pulmonary embolism, followed by deep vein thrombosis of the right upper limb. Her pus polymerase chain reaction test detected 16s rRNA gene, suggestive of gram-negative anaerobic bacilli, and anaerobic blood culture grew Dialister pneumosintes . After a prolonged course of illness and antibiotic treatment, she recovered well, and now is back to her normal activities. Conclusions: Potential life-threatening complications may develop from periodontal infection by this microorganism. In patients being treated for sepsis of unknown origin, not responding to antibiotic treatment, and with a history of recent periodontal infection, a deep-seated abscess needs to be considered.

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Section: Discussionmentioning

confidence: 99%

A Case of Dialister pneumosintes Bacteremia-Associated Neck and Mediastinal Abscess

et al. 2021

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“…Micro-organisms found and timing of clinical findings strongly suggest that the most likely underlying cause of this vertebral osteomyelitis was the surgical tracheotomy. Namely, the presence in blood cultures of D. pneumosintes, which is a commensal organism exclusively found in the oral cavity, points towards an oro-pharyngeal source [4]. In addition, sepsis and neurologic symptoms occurred 30 days after this procedure, which is consistent with usual timing of vertebral osteomyelitis, a diagnosis often delayed by several months [5].…”

Section: Discussionmentioning

confidence: 83%

Cervical anaerobic vertebral osteomyelitis following surgical tracheotomy: a case report

et al. 2019

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Background We report a rare case of anaerobic vertebral osteomyelitis associated with surgical tracheotomy which has never been reported to the best of our knowledge. Case presentation A healthy 39-year-old man was admitted to intensive care for a severe brain trauma injury where a surgical tracheotomy was performed. He was discharged to a rehabilitation centre after 54 days hospital stay. During rehabilitation, he developed progressive and febrile tetraplegia associated with cervical pain, requiring an intensive care readmission. A polymicrobial anaerobic bloodstream infection was revealed and magnetic resonance imaging diagnosed cervical vertebral osteomyelitis. Both the type of anaerobic micro-organisms found and the timing of the symptoms strongly suggest that the surgical tracheotomy was responsible for this rare case of cervical vertebral osteomyelitis. The patient was successfully treated by a prolonged antimicrobial therapy and by surgical laminectomy. Conclusions Tracheotomy may generate anaerobic bacteraemia and related osteomyelitis in the specific setting of severe trauma patients. Clinicians should consider anaerobic vertebral osteomyelitis when they are confronted with a febrile tetraplegia after tracheotomy.

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“…We isolated it in a 40-year-old immuno-competent female patient with odontogenic CRS. Dialister pneumosintes has already been reported in chronic maxillary sinusitis of odontogenic origin [30,31].…”

Section: Discussionmentioning

confidence: 92%

Chronic Rhinosinusitis: MALDI-TOF Mass Spectrometry Microbiological Diagnosis and Electron Microscopy Analysis; Experience of the 2nd Otorhinolaryngology Clinic of Cluj-Napoca, Romania

Jeican

Tudoran

Florea

et al. 2020

JCM

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(1) Background: Chronic rhinosinusitis (CRS) represents a wide range of infectious-inflammatory processes affecting, simultaneously, the nose and paranasal sinuses mucosa. The paper presents outcomes of the investigation of CRS microbiological characteristics in a group of 32 patients. (2) Methods: The purulent samples were collected during functional endoscopic sinus surgery. Agar plates were incubated and examined. All types of colonies were identified using Matrix-Assisted Laser Desorption - Ionisation-Time of Flight Mass Spectrometry (MALDI-TOF MS). For scanning electron microscopy, samples were fixed and sputter-coated with 10 nm gold and analyzed using a scanning electron microscope. For transmission electron microscopy, samples were fixed, postfixed, and dehydrated. After polymerization, ultrathin sections were collected on carbon coated copper grids and analyzed with Jeol JEM1010 TEM. (3) Results: Positive microbiological diagnosis was obtained in 62.5% of cases. The most frequent species found are Staphylococcus aureus and Streptococcus constellatus subsp. pharyngis. Corynebacterium aurimucosum and Eggerthia catenaformis were unreported species in CRS until the present. Biofilm was evidenced in 43.7% of sinus mucosa samples. Ciliary disorientation, atrophy, and no ciliated cells were also identified. (4) Conclusion: The microbial factor—pathogen or opportunistic—is one of the most important pathological links in chronic rhinosinusitis. MALDI-TOF MS allows easily and quickly identification of germs.

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<i>Dialister pneumosintes</i> Bacteremia Caused by Dental Caries and Sinusitis

Cited by 14 publications

References 31 publications

A Case of Dialister pneumosintes Bacteremia-Associated Neck and Mediastinal Abscess

A Case of Dialister pneumosintes Bacteremia-Associated Neck and Mediastinal Abscess

Cervical anaerobic vertebral osteomyelitis following surgical tracheotomy: a case report

Chronic Rhinosinusitis: MALDI-TOF Mass Spectrometry Microbiological Diagnosis and Electron Microscopy Analysis; Experience of the 2nd Otorhinolaryngology Clinic of Cluj-Napoca, Romania

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