&lt;i&gt;Eimeria tenella&lt;/i&gt; oocyst excretion and riboflavin supplement in infected chicken

Jarujareet, Wipaporn; Shigenoki, Yurika; Taira, Kensuke; Ooi, Hong Kean

doi:10.1292/jvms.18-0219

Cited by 5 publications

(2 citation statements)

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“…During Eimeria infection, the parasites replicate and adhere to receptors located in the intestine epithelial surface. Intestinal compatible probiotic bacteria challenge Eimeria parasites in adhering to the intestinal mucosa and absorb receptors in the epithelial cells, preventing invasion [33]. This attachment hinders the perforation and secretion of Eimeria sporozoites into the intestinal mucosa, further resulting in reduced proliferation and oocyst shedding [58].…”

Section: Modulation Of Gut Microbiota By Probiotics Against Coccidial Infectionmentioning

confidence: 99%

Understanding the interactions betweenEimeriainfection and gut microbiota, towards the control of chicken coccidiosis: a review

2021

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The gastrointestinal tract in poultry harbours a diverse microbial community that serves a crucial role in digestion and protection. Disruption of the gut environment due to Eimeria spp. parasite infection causes an imbalance in intestinal homeostasis, driving the increment of pathogens such as Clostridium species. Coccidiosis infection affects the composition and integrity of gut microbiota, resulting in elevated susceptibility to diseases that pose a serious threat to the overall health and productivity of chickens. Anticoccidial drugs have proven effective in curbing coccidiosis but with concerning drawbacks like drug resistance and drug residues in meat. The exploration of natural alternative strategies such as probiotics and phytochemicals is significant in controlling coccidiosis through modification and restoration of gut microbiota, without inducing drug resistance. Understanding the interaction between Eimeria parasites and gut microbiota is crucial for the control and prevention of coccidiosis, and the development of novel alternative treatments.

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Section: Modulation Of Gut Microbiota By Probiotics Against Coccidial Infectionmentioning

confidence: 99%

Understanding the interactions betweenEimeriainfection and gut microbiota, towards the control of chicken coccidiosis: a review

2021

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“…Eimeria infection has a severe impact on broilers resulting in known physical symptoms such as depressed growth performance, the decline in body weight gain, and low production ( During Eimeria infection, the parasites replicate and adhere to receptors located in the intestines' epithelial surface. Intestinal compatible probiotic bacteria challenge Eimeria parasite in adhering to the intestinal mucosa and absorb receptors in the epithelial cells, preventing invasion (Jarujareet et al, 2018). This attachment hinders the perforation and secretion of Eimeria sporozoites into the intestinal mucosa, further resulting in reduced proliferation and oocyst shedding (Oyewole et al, 2018).…”

Section: Effect Of Coccidian (Eimeria) Infection and Pathogenicity In...mentioning

confidence: 99%

Designing T-cell epitope-based vaccine against Eimeria infection in chicken using immunoinformatics approach.

Madlala

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Chicken coccidiosis is the most significant ubiquitous, intestinal parasitic disease known to infect chickens globally. It is recognised for incurring significant production loss to the poultry industry, caused by single or multiple Eimeria spp. infections which threaten chicken welfare and productivity. The emergence of drug resistance in parasites and pathogenicity reversion has put pressure on the poultry industry to reduce chemoprophylactic drugs and live vaccines as preventive measures against coccidiosis. Recombinant DNA vaccines have shown promising results as an alternative option, but complete protection has not been reported highlighting the need for the design of new vaccine against this disease. In this study, Eimeria antigens Immune Mapped Protein-1(IMP1) and Microneme Protein-2(MIC2) were explored using reverse vaccinology and immunoinformatics tool to predict and design potential multiepitope vaccine candidate against coccidiosis. A total of 28 and 19 antigenic T-cell epitopes were predicted and used to construct two multiepitope vaccines with 610 and 512 amino acids for IMP1 and MIC2, respectively. The produced vaccines exhibited favoured characteristics for an ideal vaccine candidate; they were antigenic (Vaxijen score of 0.5989 and 0.5103), immunogenic (scores: 10.15 and 9 419), thermostable (instability index <40 ), and non-allergic. The presence of IFN-gamma and IL-4 inducing epitopes in the constructed vaccine enables vaccine to trigger a cellular and humoral response within the host. Molecular docking of designed vaccines with toll-like receptors (TLR4 and TLR5) to determine vaccine interaction and stability was confirmed by molecular dynamics simulation root-mean square deviation (RMDS) and root-mean-square fluctuation (RMSF) analysis. The designed vaccines induced immune response through production of cytokines and antibodies associated with tertiary response. When exposed to online immune simulation C-ImmSim, both vaccines produced potent immune response through production of IgG, Tc and Th cell and memory Bcells. The constructed multiepitope vaccine in this present study is highly promising and as such further experimental work should be done to confirm its suitability against chicken coccidiosis.

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Natural Alternatives to Anticoccidial Drugs to Sustain Poultry Production

Aguiar-Martins,

Burrell,

Blake

et al. 2023

Sustainable Use of Feed Additives in Livestock

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<i>Eimeria tenella</i> oocyst excretion and riboflavin supplement in infected chicken

Cited by 5 publications

References 10 publications

Understanding the interactions betweenEimeriainfection and gut microbiota, towards the control of chicken coccidiosis: a review

Understanding the interactions betweenEimeriainfection and gut microbiota, towards the control of chicken coccidiosis: a review

Designing T-cell epitope-based vaccine against Eimeria infection in chicken using immunoinformatics approach.

Natural Alternatives to Anticoccidial Drugs to Sustain Poultry Production

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