&lt;i&gt;Elizabethkingia meningoseptica&lt;/i&gt; as an Unusual Pathogen Causing Healthcare-associated Bacteriuria

Zong, Zhiyong

doi:10.2169/internalmedicine.53.2319

Cited by 11 publications

(13 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have reported that Elizabethkingia spp., which are Gram-negative bacteria, show excellent resistance to antibiotics, which may explain why patients are difficult to cure of these infections [35–37]. We found that E. miricola mainly parasitizes the neurological organs, such as the brain.…”

Section: Discussionmentioning

confidence: 90%

Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus

Huang

Feng

Tang

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Most species of the genus Elizabethkingia are pathogenic to humans and animals, most commonly causing meningitis. However, our understanding of the pathogenic mechanisms involved is poor and there have been few pathological studies of Elizabethkingia spp. in animals. To understand the host injury induced by Elizabethkingia spp., we established a model of E. miricola infection in the black-spotted frog (Pelophylax nigromaculatus). The systematic pathology in and oxidative damage in the infection model were investigated. Our results show that recently isolated E. miricola is a bacterium that mainly parasitizes the host brain and that neurogenic organs are the predominant sites of damage. Infection mainly manifested as severe brain abscesses, meningoencephalitis, necrotic spondylitis, and necrotic retinitis. The liver, spleen, kidney, gastrointestinal tract, and lung were also affected to varying degrees, with bacterial necrotic inflammation. P. nigromaculatus also suffered enormous damage to its oxidative system during E. miricola infection, which may have further aggravated its disease state. Our results provide a preliminary reference for the study and treatment of Elizabethkingia spp.-induced neurological diseases in animals.

show abstract

Section: Discussionmentioning

confidence: 90%

Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus

Huang

Feng

Tang

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…(Han and Andrade, 2005 ), Elizabethkingia spp. (Zong, 2014 ; Hagiya et al, 2015 ), and Methylobacterium spp. (Lee et al, 2004 ) that are increased in UUI have been associated previously with urinary tract infections.…”

Section: Resultsmentioning

confidence: 99%

Does the Urinary Microbiome Play a Role in Urgency Urinary Incontinence and Its Severity?

Karstens

Asquith

Davin

et al. 2016

Front. Cell. Infect. Microbiol.

220

186

View full text Add to dashboard Cite

Objectives: Traditionally, the urinary tract has been thought to be sterile in the absence of a clinically identifiable infection. However, recent evidence suggests that the urinary tract harbors a variety of bacterial species, known collectively as the urinary microbiome, even when clinical cultures are negative. Whether these bacteria promote urinary health or contribute to urinary tract disease remains unknown. Emerging evidence indicates that a shift in the urinary microbiome may play an important role in urgency urinary incontinence (UUI). The goal of this prospective pilot study was to determine how the urinary microbiome is different between women with and without UUI. We also sought to identify if characteristics of the urinary microbiome are associated with UUI severity.Methods: We collected urine from clinically well-characterized women with UUI (n = 10) and normal bladder function (n = 10) using a transurethral catheter to avoid bacterial contamination from external tissue. To characterize the resident microbial community, we amplified the bacterial 16S rRNA gene by PCR and performed sequencing using Illumina MiSeq. Sequences were processed using the workflow package QIIME. We identified bacteria that had differential relative abundance between UUI and controls using DESeq2 to fit generalized linear models based on the negative binomial distribution. We also identified relationships between the diversity of the urinary microbiome and severity of UUI symptoms with Pearson's correlation coefficient.Results: We successfully extracted and sequenced bacterial DNA from 95% of the urine samples and identified that there is a polymicrobial community in the female bladder in both healthy controls and women with UUI. We found the relative abundance of 14 bacteria significantly differed between control and UUI samples. Furthermore, we established that an increase in UUI symptom severity is associated with a decrease in microbial diversity in women with UUI.Conclusions: Our study provides further characterization of the urinary microbiome in both healthy controls and extensively phenotyped women with UUI. Our results also suggest that the urinary microbiome may play an important role in the pathophysiology of UUI and that the loss of microbial diversity may be associated with clinical severity.

show abstract

“…Second, the organism rarely results in a UTI (6). In previous cases of UTI caused by E. meningoseptica (7)(8)(9), all of the bacterial identifications were based on the biochemical properties of the isolated pathogens. In contrast, the isolate in the present case was confirmed to be E. meningoseptica by means of 16S rRNA sequence analysis.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, although there have been a few cases of E. meningosepticarelated UTIs (7)(8)(9), there have been no reports of nephrostomy-associated cases. We herein report the first case of post-nephrostomy perinephric abscess caused by an E. meningoseptica infection that occurred in a patient with idiopathic retroperitoneal fibrosis.…”

Section: Introductionmentioning

confidence: 99%

A Nephrostomy-associated Urinary Tract Infection Caused by <i>Elizabethkingia meningoseptica</i>

et al. 2015

View full text Add to dashboard Cite

We report a case of nephrostomy-associated urinary tract infection caused by Elizabethkingia meningoseptica that occurred in a patient with retroperitoneal fibrosis. Though conventional identification methods failed to detect the causative organism, it was identified on the basis of the complete sequencing of 16S rRNA. Four weeks of levofloxacin and minocycline administration successfully eradicated the infection. E. meningoseptica rarely causes urinary tract infections, and we believe that this is the first such case in which the isolate was genetically confirmed. The accurate identification of the organism is necessary for the provision of appropriate treatment and to obtain a better understanding of its epidemiology and pathogenicity.

show abstract

<i>Elizabethkingia meningoseptica</i> as an Unusual Pathogen Causing Healthcare-associated Bacteriuria

Cited by 11 publications

References 5 publications

Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus

Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus

Does the Urinary Microbiome Play a Role in Urgency Urinary Incontinence and Its Severity?

A Nephrostomy-associated Urinary Tract Infection Caused by <i>Elizabethkingia meningoseptica</i>

Contact Info

Product

Resources

About