&lt;i&gt;Equisetum arvense&lt;/i&gt; L aqueous extract: a novel chemotherapeutic supplement for treatment of human colon carcinoma

Wang, Lei; Zhang, Luojun; Zheng, Guangtao; Luo, Haiping; El‐kott, Attalla F.; El-Kenawy, Ayman El-Meghawry

doi:10.5114/aoms/138146

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…This extract was kept at 4ºC and used for the assays. 11,12 For the growth of MDA-MB-231 cells (a TNBC cell line by ATCC, Manassas, VA, USA), it was cultured in DMEM, which contains a mixture of FBS (10%) and antibiotic-antimycotic (1%). In cell viability assay, 1×10 4 MDA-MB-231 cells were placed in each well of 96-well culture plate with 100µl of DMEM.…”

Section: Methodsmentioning

confidence: 99%

Illicium verum anticancer activity against MDA-MB-231 cell line

Pahore,

Khan,

Karim

2023

Pak J Med Sci

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Objective: To evaluate the anticancer activity of methanolic extract of Illicium verum against triple-negative breast cancer MDA-MB-231 cell line. Methods: A cell culture experimental study was carried out at Pharmacology department of Bahria University Medical and Dental College (January to June 2021) in collaboration with Aga Khan University, Karachi, Pakistan. Cell viability and proliferation assays were used to quantify dead and alive cells by utilizing a tetrazolium assay and an enzyme immunosorbent plate reader was used to calculate their absorbance. For the apoptosis initiation assay, these cells were dyed with a fluorescent stain and observed for fluorescence and apoptosis. During cell viability testing, various I. verum methanolic extract doses (0.125, 0.25, 0.5, 1, 3, 6, 12, and 25µg/ml) were employed to treat MDA-MB-231 cells, while the IC50 dose of 2.8µg/ml was used for both the cell proliferation and apoptosis initiation assays. Results: In the cell viability assay, all I. verum methanolic extract doses exhibited a substantial decrease in the viability of MDA-MB-231 cells (less than 0.01 p-value). In cell proliferation assay and apoptosis initiation, the IC50 dose of 2.8µg/ml of I. verum methanolic extract also exhibited a substantial decrease in cell division (less than 0.01 p-value) and the initiation of apoptosis in MDA-MB-231 cells. Conclusion: Illicium verum methanolic extract have strong anticancer activity against triple-negative breast cancer MDA-MB-231 cell line through cytotoxicity, proliferation reduction, and apoptosis initiation mechanisms. doi: https://doi.org/10.12669/pjms.40.1.7860 How to cite this: Pahore AK, Khan S, Karim N. Illicium verum anticancer activity against MDA-MB-231 cell line. Pak J Med Sci. 2024;40(1):---------. doi: https://doi.org/10.12669/pjms.40.1.7860 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Methodsmentioning

confidence: 99%

Illicium verum anticancer activity against MDA-MB-231 cell line

Pahore,

Khan,

Karim

2023

Pak J Med Sci

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“…Equisetum arvense L. is recognized for its high content of silicon, a compound that is associated with promoting skin health. Silicon maintains skin firmness and elasticity, while its mild exfoliating properties allow the elimination of dead skin cells and enhancing of skin texture [ 125 , 126 ].…”

Section: Introductionmentioning

confidence: 99%

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

et al. 2023

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The skin shows the physiological condition of the body’s organs and systems that prevent infections and physical damage. Throughout the ages, in folk medicine, phytotherapy was considered a primary form of treatment in all countries, including Kazakhstan, due to the abundance and availability of plant-based remedies. This paper discusses several medicinal plants that are traditionally used in the treatment of skin diseases in the Republic of Kazakhstan. The chemical composition of these plants was analyzed, with a particular focus on the biologically active basic compounds responsible for their therapeutic efficiency in treating skin ailments.

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Harnessing the therapeutic potential of phytochemicals in neuroblastoma

Ahmadi,

Bagherzadeh,

Sargazi

et al. 2024

BioFactors

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Neuroblastomas are the most common solid tumors outside of the brain that originate from immature neural crest cells, accounting for about 10% of all pediatric malignancies. The treatment for neuroblastomas involves a multimodal schedule, including surgery, radiation, chemotherapy, and immunotherapy. All these modalities are limited by side effects that might be severe, poor prognosis, and a high risk of recurrence. In the quest for additional therapeutic approaches, phytochemicals have attracted attention owing to their reported antitumor properties, safety, and multimechanistic mode of action. Several studies have used plant‐derived bioactive compounds such as phenolics and flavonoids, suggesting modulation of biomolecules and signal transduction pathways involved in neuroblastoma. We reviewed the findings of recent preclinical and clinical studies demonstrating the effects of phytochemicals on neuroblastoma, shedding light on their molecular mechanism of action and potential therapeutic applications.

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<i>Equisetum arvense</i> L aqueous extract: a novel chemotherapeutic supplement for treatment of human colon carcinoma

Cited by 5 publications

References 16 publications

Illicium verum anticancer activity against MDA-MB-231 cell line

Illicium verum anticancer activity against MDA-MB-231 cell line

Medicinal Plants of the Flora of Kazakhstan Used in the Treatment of Skin Diseases

Harnessing the therapeutic potential of phytochemicals in neuroblastoma

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