<i>Gongronema Latifolium</i> delays gastric emptying of semi-solid meals in diabetic dogs

Abstract

The aim of the study was to investigate sonographically the effect of Gongronema latifolium on gastric emptying of semi-solid meals in diabetic dogs. Twenty-five alloxan-induced diabetic dogs were randomly allotted into five groups of five dogs each in a randomised placebo-controlled study. These are placebo, prokinetic dose, low dose, moderate dose and high dose groups. The placebo group served as the control. The low, moderate and high dose groups ingested methanolic leaf extract of G. latifolium at 100 mg/kg, 250 mg/kg, 500 mg/kg respectively, while the prokinetic group ingested 0.5 mg/kg of metoclopramide. After a 12-hour fast, each group ingested its treatment capsules 30 minutes before the administration of test meal. Measurements of gastric emptying and blood glucose levels were obtained from each dog 30 minutes before and immediately after the ingestion of a test meal, every 15 minutes for another 4 hours and then every 30 minutes for further 2 hours. Gastric emptying of the moderate and high dose groups were 227.8 ± 9.9 min and 261.3 ± 19.3 min respectively and significantly (p < 0.0001) slower than the placebo control group of 143.0 ±17.8 min. The gastric emptying of the low dose group (169.8 ± 3.8) and control group did not differ significantly (p > 0.05). A strong inverse relationship between gastric emptying and the incremental blood glucose levels was noted in the diabetic dogs after the ingestion of Gongronema latifolium (r = -0.90; p < 0.0001). Gonogronema latifolium delayed gastric emptying in diabetic dogs.

Antidiabetic effects of Andrographis paniculata supplementation on biochemical parameters, inflammatory responses, and oxidative stress in canine diabetes

“…The application of plant-derived metabolites for the management of canine diabetes has been studied extensively ( Russell et al, 2008 ). Bixa orellana extract was reported to decrease the blood glucose level by increasing peripheral glucose utilization in streptozotocin-induced diabetic dogs ( Russell et al, 2008 ; Ogbu et al, 2013 ). Gongronema latifolium maintained the plasma glucose levels in alloxan-induced diabetic dogs by delaying stomach emptying ( Ogbu et al, 2013 ).…”

“…Bixa orellana extract was reported to decrease the blood glucose level by increasing peripheral glucose utilization in streptozotocin-induced diabetic dogs ( Russell et al, 2008 ; Ogbu et al, 2013 ). Gongronema latifolium maintained the plasma glucose levels in alloxan-induced diabetic dogs by delaying stomach emptying ( Ogbu et al, 2013 ). Additionally, numerous medicinal plants are reported to have the potential to improve the management of diabetes in humans ( Bindu and Narendhirakannan, 2018 ).…”

A Soxhlet Extract of Gongronema latifolium Retains Moderate Blood Glucose Lowering Effect and Produces Structural Recovery in the Pancreas of STZ-Induced Diabetic Rats

“…The effect was attributed to an insulin-like activity of the ethanolic extract [ 23 ] and more recently an insulinotropic activity [ 22 ]. Ogbu , et al [ 46 ] attributed the decrease in BGLs partly to delayed gastric emptying. Our in vitro findings showed that GLES had no effect on glucose active transport via the intestinal wall.…”