<i>IN VITRO</i> ACTIVITY AND COMPARATIVE STUDIES OF SOME ORGANOTIN(IV) BENZOATE DERIVATIVES AGAINST LEUKEMIA CANCER CELL, L-1210

Abstract

A series of dibutyl-, diphenyl-and triphenyltin(IV)

Spray deposited Mg-doped SnO2 thin film LPG sensor: XPS and EDX analysis in relation to deposition temperature and doping

“…But no strong stretching band of Sn-Cl bond at 417 cm -1 or 390 cm -1 corresponding to chlorine, is noticeable [33,34]. A very weak band appearing at 378-376cm -1 is indicative of C-O vibrations present [35].…”

Antimalarial Activity of Some Organotin(IV) Chlorobenzoate Compounds against Plasmodium falciparum

“…The critical factor affecting their biological activities is determined by the organic type groups present in Sn atom 6 , whereas the nature of the anionic groups present is only as a secondary factor 7 . The investigations on the coordination of carboxylates and their derivatives into organotin compounds have led to the isolation of some new organotin(IV) carboxylates, and carboxylate derivatives which have shown some engaging biological activities such as antitumor and anticancer [8][9][10][11] , antimicrobial [9][10][11][12] , antifungal activity 6,12,13 , anticorrosion inhibitor [14][15][16][17] , antiplasmodial 18,19 and the latest development of these compounds has led the new finding as antimalarial; therefore the investigation of organotin(IV) as possible antimalarial is still very challenging, and therefore have attracted much attention 18,19 .…”

The Chemical Analysis of Triphenyltin(IV)p-hydroxybenzoate by SquareWaveVoltammetry

“…Their activities are mainly determined by the number and the type of organic ligand attached to the Sn metal center 1,3 . These compouunds and their derivatives have been widely used and known in many biological activity tests such as antifungal [4][5][6][7] , anticancer and antitumour [8][9][10][11][12] , antiviral 13 , antibacterial 14,15 and anticorrosion [16][17][18][19][20] .…”

“…The derivatives of triphenyltin(IV) compounds with ligands of o-, m-, and phydroxybenzoic acids havesuccessfully been synthesized and have been tested their anticancer and anticorrosion activity 12,21 . In the anticorrosion test of triphenyltin(IV)-p-hydroxybenzoate, it was able to inhibit the corrosion on the hard rolled plate (HRP) steel with concentration of 100 ppm with percentage efficiency inhibition (%EI) of 80.41% 21 .…”

“…1. This compound was prepared by the reaction of triphenyltin(IV) hydroxide and p-hydroxybenzoic acid with methanol as solvent and temperature reaction of 60 o C and reflux times of 4 h. similar to analogous compounds previously prepared 11,12,20,21 .…”