<i>In vitro</i> activity of fosfomycin against uropathogen multi-drug resistant (MDR)<i> Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i>

Abstract

Urinary tract infections caused by multidrug resistant Gram negative bacilli constitute a major global healthcare problem. Fosfomycin is considered the best treatment option for such infections. Urine samples were collected and cultured in a tertiary care hospital (Urology). Identification of these uropathogens and their antibiotic sensitivity screening were performed according to CLSI guidelines. Urine samples (n=436) were selected in which Ps. aeruginosa and Acinetobacter baumannii were found to be the significant pathogens and treated-exposed to fosfomycin. Sixty six (15%) were identified as Acinetobacter baumannii, Ps. aeruginosa n=370(85%). Forty four percent of all Ps. aeruginosa were found to be multidrug resistant while 48.5% of the Acinetobacter baumannii strains were found multidrug resistant. Polymyxin B was found to be the most effective drug (100%) against all uropathogens and fosfomycin was found effective against 73% of the multidrug resistant Acinetobacter baumannii isolates and 70% of the multidrug resistant Pseudomonas aeruginosa strains. It may be concluded that antimicrobial activity (in vitro) of fosfomycin, especially against MDR uropathogens, is very effective.

Study of Fosfomycin Sensitivity in Various Bacterial Isolates in Patients of Urinary Tract Infections Attending in a Tertiary Care Hospital in Kashmir Region, India

“…,( >60) , & we concluded that UTI incidence was higher in the age group of 16-40 (43.72%) and 41-60 (24.91%). A similar study was conducted by Laari et al,(38) (2022) in Ghana (West Africa) to understand the aspect of age as a determinant of UTIs. The(…”

Exploring the Combined Efficacy of Carvacrol and Friedelin against Multi-Drug Resistant Bacteria in Upper and Lower Respiratory Tract Infections

“…The management and treatment of bacterial RTIs have historically relied on the use of antibiotics. However, the efficacy of these drugs is increasingly compromised by the emergence and spread of multi-drug resistant (MDR) bacteria [4]. The World Health Organization has identified antibiotic resistance as one of the biggest threats to global health, food security, and development today.…”