&lt;i&gt;In vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; evaluation of antitumor activity of methanolic extract of &lt;i&gt;Argyreia nervosa&lt;/i&gt; leaves on Ehrlich ascites carcinoma

Sharma, Bhawna; Dhamija, Isha; Kumar, Sandeep; Chaudhary, Hema

doi:10.3329/bjp.v10i2.22334

Cited by 5 publications

(4 citation statements)

References 22 publications

(15 reference statements)

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“…Natural products play a central role in the development of novel drug for the treatment and prevention of diseases (Khan et al, 2015;Sharma et al, 2015;Yu et al, 2013;Dhanamani et al, 2011). yellow waxy oil, steroids, terpenoids, flavonoids and tannins .…”

Section: Introductionmentioning

confidence: 99%

Assessment of dual inhibitory activity of epifriedelanol isolated from Cayratia trifolia against ovarian cancer

Palanisamy

Sowmya

Velmurugan

et al. 2016

Bangladesh J Pharmacol

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Cayratia trifolia is used as diuretic, in tumors, neuralgia and splenopathy. However, compounds depicting anti-ovarian cancer activities from this plant source have not yet been identified and structurally characterized till date. In the present study, X-ray structure of epifriedelanol, a bioactive compound, isolated from the ethanolic extract of the C. trifolia and its binding affinities against a few proteins (HER2, EGFR and CXCR4) that are reported to get overexpressed under ovarian cancer had been thoroughly studied by using molecular docking means. Binding affinities of the compound vis-à-vis that of carboplatin, a FDA approved drug to the ovarian cancer, to interact with the protein targets are quite impressive. The drug-likeness properties of the epifriedelanol and scope to develop the compound as a potent anti-ovarian cancer drug are discussed in this paper.

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Section: Introductionmentioning

confidence: 99%

Assessment of dual inhibitory activity of epifriedelanol isolated from Cayratia trifolia against ovarian cancer

Palanisamy

Sowmya

Velmurugan

et al. 2016

Bangladesh J Pharmacol

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“…Picric acid, alkaline buffer reagent, standard creatinine, surfactant, urea reagent, acid reagent, diaceylmonoxime (DAM) reagent, urea standard, buffer reagent, enzyme reagent, uric acid standard, A. nervosa, gentamicin, di-ethyl ether [ Figure 6]. [18]…”

Section: Drugs and Chemicalsmentioning

confidence: 99%

Untitled

Srikanth¹

2019

IJGP

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Objective:The objective of the present study is to develop the pharmacological activity of the herbal drug using ethanolic extract of whole plant of Argyreia nervosa which is claimed for its effective treatment of ailments with low toxicity and economic viability. Collection and authentication of whole plant A. nervosa. Extraction of leaves of A. nervosa with 90% ethanol. Phytochemical screening of ethanolic extract of A. nervosa whole plant. Pharmacological evaluation of ethanolic extract biochemical parameters such as estimation of levels of creatinine in blood serum, estimation of levels of urea in blood serum, estimation of levels of uric acid in blood serum and Statistical analysis. Materials and Methods: Picric acid, alkalin buffer reagent, standard creatinine, surfactant, urea reagent, acid reagent, diaceylmonoxime reagent, urea standard, buffer reagent, enzyme reagent, uric acid standard, A. nervosa, gentamicin, di-ethyl ether. Tests for flavonoids, tests for steroids, tests for alkaloids, tests for tannins, tests for carbohydrates, tests for cardiac glycosides, tests for anthra quinones glycosides, tests for amino acids, test for phenols, acute oral toxicity studies, experimental design: The animal experiments were performed after acclimatization animals were separated in to four groups of each group with 6 animals were placed in separate cages, collection of blood, estimation of serum creatinine, estimation of uric acid, estimation of urea, statistical report. Conclusion: The presence of flavonoids, tannins, steroids, carbohydrates, phenols etc. In acute toxicity studies the test dose 200 mg/kg and 400 mg/ kg was chosen as experimental doses. Nephroprotective activity of ethanolic extract of A. nervosa was screened for biochemical parameters (serum creatinine, serum uric acid, serum urea). The ethanolic extracts have produced effective nephroprotective action as evident by results obtained from the studies. The interpretation of the results was done after subjecting the data obtained from various studies by simple graph. The studies indicate that ethanolic extract of A. nervosa whole plant producing promising results in treatment of nephrotoxicity

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“…Argyreia nervosa (Burm.f.) Bojer, a popular herbal high ( Paulke et al, 2014 ), is known to exhibit multiple medicinal properties, such as antimicrobial, immunomodulatory, anti-inflammatory ( Bansal and Bharati, 2014 ), antihyperglycemic ( Hema Latha et al, 2008 ), antidiarrheal, antitumor ( Sharma et al, 2015 ), analgesic, and others ( Lalan et al, 2015 ). Organic fractions exhibit most of the above activities.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Anticancer Properties of Geranyl Isovalerate, an Active Ingredient of Argyreia nervosa Extract in Colorectal Cancer Cells

et al. 2021

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Chemotherapy is a general treatment procedure for cancer. The diversity in cancer incidence and the failure of therapy due to chemoresistance lead to increased cancer-related deaths. Therefore, new drugs with fewer secondary complications targeting diverse pathways are the need of the hour. Geranyl isovalerate (GIV), one of the active ingredients of ethyl acetate fraction of Argyreia nervosa is routinely used as a food flavoring agent. In this study, we found that GIV also exhibits anticancer activity when tested against the HCT116 cell line. It influenced the viability of the cells in a dose- and time-dependent manner. We examined whether GIV could induce oxidative stress and affect the mitochondrial membrane potential, thereby leading to apoptosis induction. Moreover, GIV could suppress the expression of antiapoptotic genes, such as BCl2 and PARP, and induce the expression of proapoptotic genes, such as Caspase 3 and 9. This is the first study demonstrating the anticancer activity of GIV and providing evidence for its mechanism of action. In conclusion, this study proposes GIV as a potential lead or supplementary molecule in treating and preventing colorectal cancer (CRC). Based on our findings, we conclude that GIV may be a viable lead or supplementary molecule for treating and preventing CRC.

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<i>In vitro</i> and <i>in vivo</i> evaluation of antitumor activity of methanolic extract of <i>Argyreia nervosa</i> leaves on Ehrlich ascites carcinoma

Cited by 5 publications

References 22 publications

Assessment of dual inhibitory activity of epifriedelanol isolated from <i>Cayratia trifolia</i> against ovarian cancer

Assessment of dual inhibitory activity of epifriedelanol isolated from <i>Cayratia trifolia</i> against ovarian cancer

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Evaluation of the Anticancer Properties of Geranyl Isovalerate, an Active Ingredient of Argyreia nervosa Extract in Colorectal Cancer Cells

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