&lt;i&gt;In vitro&lt;/i&gt; Anti-Leishmania Activity and Safety of Newly Synthesized Thiazolo Pyrimidine Derivatives Augmented with Interleukine-12 (IL-12) in BALB/c Mice Experimentally- Infected with Cutaneous Leishmaniasis

Bahashwan, Saleh; Ramadan, Mohamed; Aboonq, Moutasem Salih; Fayed, Ahmed A.

doi:10.4314/tjpr.v14i11.4

Trop. J. Pharm Res

2015

DOI: 10.4314/tjpr.v14i11.4

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<i>In vitro</i> Anti-Leishmania Activity and Safety of Newly Synthesized Thiazolo Pyrimidine Derivatives Augmented with Interleukine-12 (IL-12) in BALB/c Mice Experimentally- Infected with Cutaneous Leishmaniasis

Saleh Bahashwan¹,

Mohamed Ramadan²,

Moutasem Salih Aboonq³

et al.

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Structure-Activity Relationships of Pyrimidine Derivatives and their Biological Activity - A Review

Natarajan

Helina

et al. 2023

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Background: Heterocycles are a major role in many fields of biochemical and physiological such as amino acids, DNA bases, vitamins, endogenous neurotransmitters, etc. Nitrogen-containing heterocyclic compounds play a vital role in medicinal chemistry and exhibit notable biological and pharmacological activities. In the past two decades, scientists focused more on the diverse biological activities of pyrimidine derivatives. Pyrimidine is a six-membered heterocyclic compound and it is present naturally in nucleic acid components (uracil, thymine, and cytosine) and vitamin B1, it is a promising lead molecule for the synthesis of compounds with various substitutions to treat various diseases. Objective: We focused on the Structure-Activity Relationship of pyrimidine derivatives and its various biological activities reported from the year 2010 to date. Results: From this review, we concluded that the position of substituents in the pyrimidine nucleus greatly influences biological activities. Thus, the pyrimidine nucleus showed anti-microbial, anti-cancer, anti-inflammatory, anti-tubercular, anti-convulsant, antihypertensive, anthelmintic, anti-depressant, analgesic, anti-hyperglycemic activities, etc. Conclusion: This study provides an overview of the pyrimidine nucleus and its derivatives from the year 2010 to date. There is the future scope for identifying a lead molecule for the target biological activity.

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Structure-Activity Relationships of Pyrimidine Derivatives and their Biological Activity - A Review

Natarajan

Helina

et al. 2023

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<i>In vitro</i> Anti-Leishmania Activity and Safety of Newly Synthesized Thiazolo Pyrimidine Derivatives Augmented with Interleukine-12 (IL-12) in BALB/c Mice Experimentally- Infected with Cutaneous Leishmaniasis

Cited by 1 publication

References 21 publications

Structure-Activity Relationships of Pyrimidine Derivatives and their Biological Activity - A Review

Structure-Activity Relationships of Pyrimidine Derivatives and their Biological Activity - A Review

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