&lt;i&gt;In vitro&lt;/i&gt; antimicrobial evaluation of pyrazolone derivatives

Ahar, Leile Rahimi; Sadr, Moayad Hossaini; Zare, Karim; Tabatabaei, Samad Motameni

doi:10.3329/bjp.v10i1.21166

Cited by 1 publication

(1 citation statement)

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“…In order to improve the safety and effectiveness of pyrazolone derivatives, the researchers have focused their work to modulate this scaffold [1]. As a result, many pyrazolone derivatives have been developed and evaluated for other important effects such as antioxidant [2], antimicrobial [3] and antitumour [4].…”

Section: Introductionmentioning

confidence: 99%

The Effects of New 1,3-Thiazolidine-4-Ones With Pyrrazolone Scafold on Motor Function in Mice

Apotrosoaei¹

2019

FARMACIA

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The aim of this study was to investigate the effects of new 1,3-thizolidine-4-ones with pyrazolone scaffold (7a-m) on motor function in mice, using RotaRod performance and spontaneous locomotor activity tests. The toxicity screening of these compounds was also performed. The results of RotaRod performance test showed that the compounds don't have appreciable negative influence on neuromuscular activity, the recorded values being comparable with those of phenazone and control, so it could be appreciated that these compounds don't have neurotoxic effects. In the case of spontaneous locomotor activity test, the most intense negative effect was observed for 7j (3-OH,4-OCH 3 ), for which the horizontal and vertical movements were lower than phenazone and control at all three-time intervals (1h, 2h, 4h). For other derivatives no appreciable negative effect on spontaneous locomotor activity was observed. Referring to the toxicity degree, all tested compounds showed lower toxicity in reference with phenazone, which supports the favourable influence of 1,3-thiazolidine-4-one moiety on pyrazolone scaffold. RezumatScopul acestui studiu a fost de a evalua efectele unor noi derivați de 1,3-tiazolidin-4-onă cu structură pirazolonică (7a-m) asupra funcției motorii la șoarece, utilizând testul tijei rotante (RotaRod) și testul activității locomotorii spontane. S-a determinat totodată și gradul de toxicitate al compușilor testați. Rezultatele testului tijei rotante au arătat că derivații studiați nu au o influență negativă apreciabilă asupra activității neuromusculare, valorile înregistrate fiind comparabile cu cele pentru fenazonă și lotul martor, putându-se astfel aprecia că derivații nu au efecte neurotoxice. În cazul activității locomotorii spontane, cel mai intens efect negativ a fost observat pentru compusul 7j (3-OH,4-OCH 3 ), pentru care mișcările în plan orizontal și vertical au fost mai reduse comparativ cu fenazona și lotul martor, la toate cele trei intervale de timp studiate (1 oră, 2 ore, 4 ore). Pentru ceilalți derivați nu s-a observat un efect negativ apreciabil asupra activității locomotorii. Referitor la gradul de toxicitate, rezultatele au arătat că toți derivații studiați sunt mai puțin toxici comparativ cu fenazona, ceea ce susține influența favorabilă a ciclului de 1,3-tiazolidin-4-onă asupra structurii pirazolonice.

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Section: Introductionmentioning

confidence: 99%

The Effects of New 1,3-Thiazolidine-4-Ones With Pyrrazolone Scafold on Motor Function in Mice

Apotrosoaei¹

2019

FARMACIA

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show abstract

<i>In vitro</i> antimicrobial evaluation of pyrazolone derivatives

Cited by 1 publication

References 26 publications

The Effects of New 1,3-Thiazolidine-4-Ones With Pyrrazolone Scafold on Motor Function in Mice

The Effects of New 1,3-Thiazolidine-4-Ones With Pyrrazolone Scafold on Motor Function in Mice

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