<i>In Vitro</i> Antitrypanosomal Activity of the Secondary Metabolites from the Mutant Strain IU-3 of the Insect Pathogenic Fungus <i>Ophiocordyceps coccidiicola</i> NBRC 100683

Secondary metabolite arsenal of an opportunistic pathogenic fungus

“…BGC 15 (Helvolic acid). Following on trypacidin, helvolic acid also exhibits antiprotozoal activity [67] and is produced by several fungal spp. in addition to A. fumigatus, including several plant and insect pathogens and many endophytes [28,68,69].…”

A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen

“…Helvolic acid is a fusidane antibiotic that exhibits in vitro antiprotozoal activity against the trypanosome Trypanosoma brucei brucei GUTat3.1, the causative agent of African sleeping sickness [29], and helvolic acid derivatives exhibit antibacterial activity against Streptococcus agalactiae and Staphylococcus aureus [30]. In addition, helvolic acid also affects mammalian cell lines, decreasing the beat frequency of ciliated respiratory epithelium, a process important in preventing colonization by A .…”

Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi

“…The third example is the direct application of destruxins as insecticidal agents [ 19 ]. Destruxins were isolated from a variety of fungi such as Metarrhizium anisopliae [ 16 ], Beauveria felina [ 123 ], and Ophiocordyceps coccidiicola [ 128 ]. With the increasing understanding of the biosynthetic pathways of some fungal CDPs, we can rationally design bioengineering approaches such as chemoenzymatics, mutasynthesis, site-directed mutagenesis, and combinatorial biosynthesis.…”