<i>In vitro</i> Protective Effect of Ganoderol A Isolated from <i>Ganadermalucidum</i> Against Ultraviolet A Radiation and its Anti-inflammatory Properties

Abstract

Purpose: To evaluate the ultraviolet A (UVA) protection and anti-inflammatory activity of ganoderol

Influence of cultivation substrate on antioxidant activities and triterpenoid profiles of the fruiting body of Ganoderma lucidum

“…Ganoderol A is classified as a lanostane-type triterpenoid, with a tetracyclic structure consisting of four fused rings. It has been a subject of research due to its potential health-promoting properties, including antioxidant and anti-inflammatory effects ( 31 ). Our study revealed substantial differences in the content of ganoderol A between SGL and WGL samples, with SGL samples containing a notable 10-fold increase in ganoderol A compared to WGL samples, as shown in Figure 7B .…”

Effects of Carissa carandas Linn. Fruit, Pulp, Leaf, and Seed on Oxidation, Inflammation, Tyrosinase, Matrix Metalloproteinase, Elastase, and Hyaluronidase Inhibition

“…Besides, fibroblasts are present throughout the matrix and connective tissue of the body. Therefore, NIH-3T3 cell line has been previously used for studying the regulation of fibrillar collagen synthesis, cellular cytotoxicity, genotoxicity, inhibition of UV-induced skin photoaging, inhibition of MMPs, etc., of tested compounds or topical formulations [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Briefly, NIH/3T3 cell line were cultured in DMEM culture medium with 10.0% newborn calf serum, and 1.0% antibiotic–antimycotic (100×).…”

Anti-aging Effect of Ganoderol A in UVA-irradiated Normal Human Epidermal Keratinocytes

“…또한 세포외기질의 하나인 히알루론산 (hyaluronic acid, HA)을 합성하는 효소인 HAS2는 인간각질형성 세포에서 자외선에 의해 HAS2의 발현이 감소된다는 연구 보고된 바 있다 (Hašová et al, 2011;Park & Shim, 2016 (Shim & Park, 2017;Eckert et al, 2005). (Hajjaj et al, 2005;Jin et al, 2015). -Chikuma et al, 2008;Hašová et al, 2011;Sougrat et al, 2002).…”