&lt;i&gt;In Vitro&lt;/i&gt; Radical Scavenging Activity of the Leaf and Bark Extracts of &lt;i&gt;Senna singueana&lt;/i&gt; (Del). Lock

Gebrelibanos, Mebrahtom; Asres, Kaleab; Veeresham, Ciddi

doi:10.4314/epj.v25i2.35121

Cited by 8 publications

(9 citation statements)

References 14 publications

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“…[ 11 ], Xanthium strumarium L. [ 12 ], Senna singueana (Del). Lock [ 13 ], Glinus lotoides L. [ 14 ], Kniphofia foliosa Hochst [ 15 ], Sideroxylon oxyacanthum Baill., Clematis simensis Fresen, and Dovyalis abyssinica (A. Rich) Warburg [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

et al. 2020

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This review provides an overview on the active phytochemical constituents of medicinal plants that are traditionally used to manage cancer in Ethiopia. A total of 119 articles published between 1968 and 2020 have been reviewed, using scientific search engines such as ScienceDirect, PubMed, and Google Scholar. Twenty-seven medicinal plant species that belong to eighteen families are documented along with their botanical sources, potential active constituents, and in vitro and in vivo activities against various cancer cells. The review is compiled and discusses the potential anticancer, antiproliferative, and cytotoxic agents based on the types of secondary metabolites, such as terpenoids, phenolic compounds, alkaloids, steroids, and lignans. Among the anticancer secondary metabolites reported in this review, only few have been isolated from plants that are originated and collected in Ethiopia, and the majority of compounds are reported from plants belonging to different areas of the world. Thus, based on the available bioactivity reports, extensive and more elaborate ethnopharmacology-based bioassay-guided studies have to be conducted on selected traditionally claimed Ethiopian anticancer plants, which inherited from a unique and diverse landscape, with the aim of opening a way forward to conduct anticancer drug discovery program.

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Section: Introductionmentioning

confidence: 99%

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

et al. 2020

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“…117 Moreover, the inner bark of the plant is chewed fresh to soothe stomach spasm and smoke from the wood and bark is used as smoke baths. 119 Studies carried out on sister species have led to the isolation of the stilbene 3,4 0 ,5trihydroxystilbene (resveratrol, 78) from S. italica, a plant used traditionally in the northern parts of the Limpopo province of South Africa for the treatment of STIs, 120,121 as well as D-pinitol 123 Compounds 80 and 81 demonstrated moderate to high antimicrobial activity against both Gram-positive and Gram negative bacteria which validates the in vitro activity of the crude extract and the ethnomedicinal use of the plant. 119 Studies carried out on sister species have led to the isolation of the stilbene 3,4 0 ,5trihydroxystilbene (resveratrol, 78) from S. italica, a plant used traditionally in the northern parts of the Limpopo province of South Africa for the treatment of STIs, 120,121 as well as D-pinitol 123 Compounds 80 and 81 demonstrated moderate to high antimicrobial activity against both Gram-positive and Gram negative bacteria which validates the in vitro activity of the crude extract and the ethnomedicinal use of the plant.…”

Section: Xanthorrhoeaceaementioning

confidence: 99%

The chemistry and bioactivity of Southern African flora II: flavonoids, quinones and minor compound classes

et al. 2015

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This review is intended to highlight the relevance of natural products in drug discovery paying particular attention to those derived from Southern African medicinal plants with diverse biological activities. In this review series, a literature survey led to the collection of 864 secondary metabolites from 101 plant species from 57 plant families. A correlation between the known biological activities of isolated compounds and the ethnobotanical uses of the plants has been attempted. Part I focused on alkaloids and terpenoids, while this part is focused on the bioactivities of flavonoids, quinines and other minor, unique compound classes which correlate with their ethnobotanical uses in African traditional medicine (ATM).

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“…Because, the relatively non polar solvent fractions (diethyl ether and chloroform) possessed lower percentage yield than 80% methanol fraction, further partitioning using ethyl acetate was made on the 80% methanol fraction. Of course, previous works indicated that S. singueana constituents of intermediate polarity showed radical scavenging activities and that test sample extracts showed higher solubility in organic solvents like methanol and ethyl acetate than in non polar solvents or polar solvents like water (Gebrelibanos et al, 2007). Hence, further fractionation which was carried out to locate the fraction(s) that contain active constituents was made on the 80% methanol fraction using ethyl acetate.…”

Section: Extraction and Fractionationmentioning

confidence: 99%

“…for purposes of smoke baths to containers of milk and milk products. Scientific reports indicate that the plant has anthelminthic properties (Kawanga, 2007), antiprotozoal activity against cestodes of Hymenolepis diminuta (Mølgaard et al, 2001), antiplasmodial, antinociceptive, antipyretic (Adzu et al, 2003), in vivo antioxidant and hepatoprotective properties (Ottu et al, 2011), in vitrofree radical scavenging activity (Gebrelibanos et al, 2007), enzyme inhibition acivities (strong-acetylcholinestrase and carboxylesterase inhibitory activities and weak gluthation-S-transferase and xanthine oxidase inhibitory activities) (Bangou et al, 2011), antiulcer effects (Ode and Asuzu, 2011)and reduce both gastric free-HCl and total acids (Ode and Onakpa, 2010).Hydrochloric acid (HCl) exists in two forms in the gastric juice; as a free HCl and as HCl bound up with acidic proteins and other acidic compounds of the gastric juice. The total acidity of the gastric juice is the sum of the free acidity (the free HCl) and the bonded acidity; and80% methanol extract from leaves of the plant reduced both free and total acids (Ode and Onakpa, 2010).…”

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confidence: 99%

<em>In vitro</em> Erythrocyte Haemolysis Inhibition Properties of <em>Senna singueana</em> Extracts

Gebrelibanos¹

2012

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Both leaves and bark of Senna singueana (Del.) Lock(Fabaceae) are traditionally used, in some parts of Ethiopia, for the treatment of a form of skin cancer. Also the inner bark of the plant is chewed fresh to soothe stomach spasm and smoke from the wood and bark is used as smoke baths. The objective of this work was to study the antioxidant properties, of this plant using an erythrocyte haemolysis inhibition assay, because one way to justify the traditional anticancer uses can be through the concept of antioxidant effect. Crude extracts from leaves and bark of S. singueana were prepared by maceration with 80% methanol. Fractions were prepared from both leaves and bark using solvents of different polarity (diethyl ether, chloroform, and 80% methanol). The 80% methanol fraction was partitioned using ethyl acetate. These crude extracts and solvent fractions were then evaluated for their capacity to inhibit H 2 O 2 induced erythrocyte haemolysis. Also to evaluate the presence of any intrinsic haemolysis inducing constituents such as saponins, foaming index determination and preliminary haemolysis activity determination tests were performed on extracts from the bark and leaves of the plant. The results revealed that the ethyl acetate solvent fraction from the bark of S. singueana exhibited concentration dependent erythrocyte haemolysis inhibitory activity, with an IC 50 value of 233 g/ml. However, the other solvent fractions and crude extracts did not show meaningful haemolysis inhibitory activity. The results of the foaming index determination and preliminary haemolysis activity determination tests showed the presence of saponins; but, none of the dilutions of the extracts showed any visible haemolysis activity compared to H 2 O 2 , used as a control. The results of the ethyl acetate solvent fraction from the bark of the plant could indicate the possible presence of constituents that can inhibit erythrocyte haemolysis, which in turn, could be due to lipid peroxidation inhibitory activity.

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<i>In Vitro</i> Radical Scavenging Activity of the Leaf and Bark Extracts of <i>Senna singueana</i> (Del). Lock

Cited by 8 publications

References 14 publications

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

The chemistry and bioactivity of Southern African flora II: flavonoids, quinones and minor compound classes

<em>In vitro</em> Erythrocyte Haemolysis Inhibition Properties of <em>Senna singueana</em> Extracts

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