&lt;i&gt;In vitro&lt;/i&gt; Simulation Study of Individualized Chemotherapy in Lung Cancer

Cai, Li; Gemma, Akihiko; Minegishi, Yuji; Matsuda, Kuniko; Seike, Yoko; Noro, Rintaro; Shionoya, Aki; Kawakami, Akiko; Ogawa, Naoki; Kudoh, Shoji

doi:10.1272/jnms.74.217

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Evaluation of the enzymatic activity of C29F7.3, F40F8.1, B0001.4, T07C4.1 and R12E2.11 was performed as described by Li et al. [35] and Krungkrai et al. [36], with a few modifications.…”

Section: Methodsmentioning

confidence: 99%

Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5‐fluorouracil inCaenorhabditis elegans

et al. 2009

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Pyrimidine biosynthesis enzymes function in many cellular processes and are closely associated with pyrimidine antagonists used in cancer chemotherapy. These enzymes are well characterized from bacteria to mammals, but not in a simple metazoan. To study the pyrimidine biosynthesis pathway in Caenorhabditis elegans, we screened for mutants exhibiting resistance to the anticancer drug 5‐fluorouracil (5‐FU). In several strains, mutations were identified in ZK783.2, the worm homolog of human uridine phosphorylase (UP). UP is a member of the pyrimidine biosynthesis family of enzymes and is a key regulator of uridine homeostasis. C. elegans UP homologous protein (UPP‐1) exhibited both uridine and thymidine phosphorylase activity in vitro. Knockdown of other pyrimidine biosynthesis enzyme homologs, such as uridine monophosphate kinase and uridine monophosphate synthetase, also resulted in 5‐FU resistance. Uridine monophosphate kinase and uridine monophosphate synthetase proteins are redundant, and show different, tissue‐specific expression patterns in C. elegans. Whereas pyrimidine biosynthesis pathways are highly conserved between worms and humans, no human thymidine phosphorylase homolog has been identified in C. elegans. UPP‐1 functions as a key regulator of the pyrimidine salvage pathway in C. elegans, as mutation of upp‐1 results in strong 5‐FU resistance.

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“…Evaluation of the enzymatic activity of C29F7.3, F40F8.1, B0001.4, T07C4.1 and R12E2.11 was performed as described by Li et al. [35] and Krungkrai et al. [36], with a few modifications.…”

Section: Methodsmentioning

confidence: 99%

Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5‐fluorouracil inCaenorhabditis elegans

et al. 2009

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In vitro drug sensitivity (IDS) of patient-derived primary osteosarcoma cells as an early predictor of the clinical outcomes of osteosarcoma patients

Klangjorhor

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Teeyakasem

et al. 2020

Cancer Chemother Pharmacol

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A Drug Interaction between Crizotinib and Warfarin in Non-Small-Cell Lung Cancer: A Case Report

et al. 2017

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We report a case of increased prothrombin time-international normalized ratio (PT-INR) when crizotinib and warfarin were co-administered. A 74-year-old Japanese woman presented to the hospital with dyspnea, and was diagnosed with anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC). Three years after surgical resection of the tumor, the patient started crizotinib because of the recurrence of NSCLC. She received 2 mg/day warfarin due to a medical history of cerebral infarction and chronic atrial fibrillation. Before crizotinib initiation, the patient's PT-INR was 2.60. After 7 days of daily doses of crizotinib, the patient's PT-INR increased to 3.65. This case report provides the first evidence of a drug interaction between crizotinib and warfarin. (J Nippon Med Sch 2017; 84: 291 293)

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<i>In vitro</i> Simulation Study of Individualized Chemotherapy in Lung Cancer

Cited by 3 publications

References 15 publications

Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5‐fluorouracil inCaenorhabditis elegans

Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5‐fluorouracil inCaenorhabditis elegans

In vitro drug sensitivity (IDS) of patient-derived primary osteosarcoma cells as an early predictor of the clinical outcomes of osteosarcoma patients

A Drug Interaction between Crizotinib and Warfarin in Non-Small-Cell Lung Cancer: A Case Report

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