&lt;I&gt;In vivo&lt;/I&gt; antimalarial effect of &lt;I&gt;Ananas comosus&lt;/I&gt; (L) Merr (Bromeliaceae) fruit peel, and gas chromatography-mass spectroscopy profiling: A possible role for polyunsaturated fatty acid

Uzor, Philip F.; Ishiwu, Blessing U; Nwodo, Ngozi Justina

doi:10.4314/tjpr.v19i1.21

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…The affinity between receptors and ligands will decrease as binding energy increases. Conversely, higher receptor affinities are associated with lower binding energy values [38,39,40,41,42,43,44,45,46,47,48,49].…”

Section: Discussionmentioning

confidence: 99%

Antimalarial activity prediction analysis of sticophus hermanni on plasmodium falciparum hexose transporter (PfHT1)

Utami¹,

Yudho²

2022

ijhs

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The objective of this study is to investigate S.hermanni's antimalarial action against PfHT1 utilizing an in silico technique. In silico method, developing a protein target database by searching and collecting the protein target structures from the Protein Data Bank (PDB) and the UNIPROT databases. PfHT1 protein (PDB ID 6m20) with glucose control. Download all ligand structures from the PubChem database. Molecular docking analysis with Molegro virtual docker predicts interactions between ligands and protein targets. The last step was docking visualization to display 3D views and their interactions with the discovery studio program. The control compound beta-D-glucopyranose binds PfHT1 at the active site GLN169, GLN305, ASN341, GLY408, ASN311, and GLN305. All active compounds of S.hermanni were able to bind to PfHT1. This indicates that all active compounds enter the cell via hexose transporter 1 (PfHT1) receptors, such as glucose. All active substances of S.hermanni have antimalaria activity through PfHT1inhibition. Almost all active substances used were similar to the control binding sites, but only quinoxaline used different binding sites. The active substance of S.hermanni has a variety of binding affinities to PfHT1.

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Section: Discussionmentioning

confidence: 99%

Antimalarial activity prediction analysis of sticophus hermanni on plasmodium falciparum hexose transporter (PfHT1)

Utami¹,

Yudho²

2022

ijhs

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“… Ganfon et al., 2012 2 Allium sativum Ayuu Allicin, Ajoene Coppi et al., 2006 3 Alstonia boonei Ahun Din -Octyl phthalate; 3-Nitrophthalic acid, bis-(2, ethylhexyl-ester) and Bis-(3, 5, 5-trimethylhexyl) phthalate Imam et al., 2017 4 Anacardium occidentale Kasu anacardic acids, cardols, and 2-methylcardols derivatives Gimenez et al.,. 2019 5 Ananas comosus Ope-Oyinbo Ehin-ahun Ekunkun Fatty acids (linoleic acid and palmitic acid) Uzor et al., 2020 6 Azadirachta indica Dogonyaro Azadirachtinand limonoids Mulla and Su 1999 , Dhar et al., 1996 , Nathan et al., 2005 7 Bridelia ferruginea Ira odan 8 Canna indica Ido 9 Capsicum frutescens Ata-Ijosi 10 Carica papaya Ibepe Papain, cystatin Seigler et al., 2002 11 Ceiba pentandra Araba pentandrin and pentandrin glucoside and beta-sistosterol and 3-beta-D-glucopyranoside Ngounou et al., 2000 . 12 Chromolaena odorata Ewe Akintola Ewe Awolowo 3, 5, 7, 3' tetrahydroxy-4'-methoxyflavone Ezenyi et al., 2014 13 Chrysophyllum albidum Agbalumo stigmasterol tetracosanoate Idowu et al., 2016 14 Citrus aurantifolia Osanwewe apigenin …”

Section: Medicinal Plants With Pharmacological and Biological Action mentioning

confidence: 99%

A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

Oladele¹,

Ajayi

Oyeleke³

et al. 2020

Heliyon

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Despite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or vaccine that can mitigate/inhibit SARS-CoV-2. Available clinical intervention for COVID-19 is only palliative and limited to support. Thus, there is an exigent need for effective and non-invasive treatment. This article evaluates the possible mechanism of actions of SARS-CoV-2 and present Nigeria based medicinal plants which have pharmacological and biological activities that can mitigate the hallmarks of the pathogenesis of COVID-19. SARS-CoV-2 mode of actions includes hyper-inflammation characterized by a severe and fatal hyper-cytokinaemia with multi-organ failure; immunosuppression; reduction of angiotensin-converting enzyme 2 (ACE2) to enhance pulmonary vascular permeability causing damage to the alveoli; and further activated by open reading frame (ORF)3a, ORF3b, and ORF7a via c-Jun N- terminal kinase (JNK) pathway which induces lung damage. These mechanisms of action of SARS-CoV-2 can be mitigated by a combination therapy of medicinal herbs based on their pharmacological activities. Since the clinical manifestations of COVID-19 are multifactorial with co-morbidities, we strongly recommend the use of combined therapy such that two or more herbs with specific therapeutic actions are administered to combat the mediators of the disease.

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“…Not only are the conventional drugs often unaffordable or inaccessible but also the rate at which Plasmodium falciparum, the causative organism, has developed resistance to the conventional drugs warrants the quest for novel and more effective agents [8] particularly from natural resources. Medicinal plants have long been used for malaria treatment in many traditional settings [9,10]. Two common ingredients in Nigeria ethnomedicine used for malaria treatment are the leaves of Persea americana and Dacryodes edulis which are used either singly or in combination.…”

Section: Introductionmentioning

confidence: 99%

Study of the Antimalarial Activity of the Leaf Extracts and Fractions of Persea americana and Dacryodes edulis and Their HPLC Analysis

Uzor

Onyishi

Omaliko

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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In the present study, the antimalarial activity of the extracts and fractions of the leaves of Persea americana and Dacryodes edulis as well as their phytochemical compositions were examined. Each of the extracts of the plants was successively fractionated to obtain hexane, ethyl acetate, methanol, and water fractions. The extracts and fractions were tested against Plasmodium berghei in both curative and suppressive antimalarial mouse models. Their major phytochemical composition was studied by the standard chemical tests and HPLC analysis. The extracts and fractions of P. americana and D. edulis demonstrated significant ( p < 0.05 ) maximal plasmodial inhibition as 52.16 ± 2.77% and 57.10 ± 1.98%, respectively, and chemosuppression of parasitemia as 64.01 ± 0.08% and 71.99 ± 0.06%, respectively. The major secondary metabolites identified in the plants include alkaloids, flavonoids, and saponins. It was concluded that P. americana and D. edulis possess promising antimalarial activity and they are potential sources of new lead compounds against malaria.

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<I>In vivo</I> antimalarial effect of <I>Ananas comosus</I> (L) Merr (Bromeliaceae) fruit peel, and gas chromatography-mass spectroscopy profiling: A possible role for polyunsaturated fatty acid

Cited by 7 publications

References 19 publications

Antimalarial activity prediction analysis of sticophus hermanni on plasmodium falciparum hexose transporter (PfHT1)

Antimalarial activity prediction analysis of sticophus hermanni on plasmodium falciparum hexose transporter (PfHT1)

A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

Study of the Antimalarial Activity of the Leaf Extracts and Fractions of Persea americana and Dacryodes edulis and Their HPLC Analysis

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