&lt;i&gt;Litsea cubeba&lt;/i&gt; Essential Oil: Component Analysis, Anti-&lt;i&gt;Candida albicans&lt;/i&gt; Activity and Mechanism Based on Molecular Docking

Li, Hong; Kong, Yiwen; Hu, Wei; Zhang, Sheng; Wang, Wei; Yang, Min; Luo, Yunping

doi:10.5650/jos.ess22108

Cited by 7 publications

(1 citation statement)

References 25 publications

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“…Plants synthesize secondary metabolites or natural products that are generally divided into three classes, including phenolics, terpenoids, and alkaloids. Numerous studies employed natural products from native plants to combat biofim-induced fungal resistance [ 42 – 45 ]. However, exploring natural products from invasive plants as antibiofilm candidate drugs is still limited.…”

Section: Discussionmentioning

confidence: 99%

Screening antibiofilm activity of invasive plants growing at the Slope Merapi Mountain, Central Java, against Candida albicans

Desrini

Girardot

Imbert

et al. 2023

BMC Complement Med Ther

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Background Candida albicans causes high-mortality candidiasis. Antifungal drug resistance demands the development of virulence factor-targeting drugs, particularly antibiofilm. This study screened the effects of five invasive plants growing in Indonesia (Mimosa pudica, Lantana camara, Acacia mangium, Ageratina riparia, and Mikania micrantha) against C. albicans biofilms. Antifungal activity, antiphospholipase activity, biofilm morphology of C. albicans, and cytotoxic capacity were also evaluated. Methods Maceration was used to extract the plants, and the most active extract inhibiting the biofilms was fractionated using liquid–liquid fractionation. Antibiofilm activity was determined by a colorimetric assay, MTT. Antifungal activity was tested using the broth microdilution method. A phospholipase assay was performed using the egg-yolk agar method. Influence on the C. albicans morphology was assessed using scanning electron microscopy (SEM). The cytotoxic effect was carried out against Vero and HeLa cell lines. Results M. pudica extracts showed the most potent antifungal efficacy with minimum inhibitory concentration (MIC) of 15.62 µg/mL and 7.81 µg/mL for aerial parts and roots, respectively. At high concentrations (500 µg/mL and 250 µg/mL), ethanol extract of M. pudica aerial parts strongly inhibited the phospholipase activity. Ethyl-acetate fraction of M. pudica aerial parts demonstrated the most potent antibiofilm activity against 24 h old biofilm of C. albicans with an inhibitory concentration (53.89%) of 62.5 µg/mL showed no cytotoxicity in both Vero and HeLa cells. This fraction affected the morphology of C. albicans and contained promising compounds for inhibiting the 24 h old biofilm of C. albicans. Conclusions Invasive M. pudica plant inhibited the growth of planktonic C. albicans cells and its ethyl acetate fraction decreased the metabolic activity of C. albicans biofilms. This result demonstrates the potential of invasive M. pudica plant to reduce biofilm-associated candida infection.

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Section: Discussionmentioning

confidence: 99%

Screening antibiofilm activity of invasive plants growing at the Slope Merapi Mountain, Central Java, against Candida albicans

Desrini

Girardot

Imbert

et al. 2023

BMC Complement Med Ther

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In Silico Design and In Vitro Assessment of Bicyclic Trifluoromethylated Pyrroles as New Antibacterial and Antifungal Agents

Hodyna,

Klipkov,

Kachaeva

et al. 2024

Chemistry & Biodiversity

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QSAR studies on the number of compounds tested as S. aureus inhibitors were performed using an interactive Online Chemical Database and Modeling Environment (OCHEM) web platform. The predictive ability of the developed consensus QSAR model was q2 = 0.79 ± 0.02. The consensus prediction for the external evaluation set afforded high predictive power (q2 = 0.82 ± 0.03). The models were applied to screen a virtual chemical library with anti‐S. aureus activity. Six promising new bicyclic trifluoromethylated pyrroles were identified, synthesized and evaluated in vitro against S. aureus, E. coli, and A. baumannii for their antibacterial activity and against C. albicans, C. krusei and C. glabrata for their antifungal activity. The synthesized compounds were characterized by 1H, 19F, and 13C NMR and elemental analysis. The antimicrobial activity assessment indicated that trifluoromethylated pyrroles 9 and 11 demonstrated the greatest antibacterial and antifungal effects against all the tested pathogens, especially against multidrug‐resistant strains. The acute toxicity of the compounds to Daphnia magna ranged from 1.21 to 33.39 mg/L (moderately and slightly toxic). Based on the docking results, it can be suggested that the antibacterial and antifungal effects of the compounds can be explained by the inhibition of bacterial wall component synthesis.

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Antifungal Efficacy of Plant Essential Oils Against Candida, Aspergillus and Cryptococcus Species

Kumari,

Imam,

Luqman

2024

Advances in Antifungal Drug Development

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<i>Litsea cubeba</i> Essential Oil: Component Analysis, Anti-<i>Candida albicans</i> Activity and Mechanism Based on Molecular Docking

Cited by 7 publications

References 25 publications

Screening antibiofilm activity of invasive plants growing at the Slope Merapi Mountain, Central Java, against Candida albicans

Screening antibiofilm activity of invasive plants growing at the Slope Merapi Mountain, Central Java, against Candida albicans

In Silico Design and In Vitro Assessment of Bicyclic Trifluoromethylated Pyrroles as New Antibacterial and Antifungal Agents

Antifungal Efficacy of Plant Essential Oils Against Candida, Aspergillus and Cryptococcus Species

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