<i>MTNR1B</i> rs1387153 Polymorphism and Risk of Gestational Diabetes Mellitus: Meta-Analysis and Trial Sequential Analysis

Abstract

Introduction: Published data on the association between the MTNR1B rs1387153 polymorphism and gestational diabetes mellitus(GDM) risk are controversial. A meta-analysis was performed to assess whether the polymorphism of MTNR1B rs1387153 is associated with GDM risk. Methods: Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases were searched to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for MTNR1B rs1387153 polymorphism and GDM were appropriately derived from fixed-effects or random effects models. Results: A total of 8 studies were enrolled in this meta-analysis. The pooled analyses revealed that MTNR1B rs1387153 polymorphism significantly increased the risk of GDM in all models. allele contrast (C vs T): OR, 0.78; 95%CI, 0.73-0.83; homozygote (CC vs TT): OR, 0.61;95% CI, 0.53-0.69; heterozygote (CT vs TT): OR, 0.78; 95% CI, 0.69-0.89; dominant model (CC +CT vs TT): OR, 0.71; 95% CI, 0.63-0.80; recessive model (CC vs CT + TT): OR, 0.73; 95%CI, 0.67-0.81). Further subgroup analyses by ethnicity of participants yielded similar positive results. Conclusion: Present meta-analysis reveals that MTNR1B rs1387153 variant may serve as genetic biomarkers of GDM.

Mechanisms and Physiological Roles of Polymorphisms in Gestational Diabetes Mellitus

“…The placental expression level of MT2 in GDM women carrying the GG and GC genotypes was higher than in those carrying the CC genotype [95]. SNPs rs1387153 (C > T) allele T and rs10830962 (C > G) allele G are both located in the intergenic region over 2 kb upstream from MTNR1B and demonstrated a significant association with an increased risk of GDM [96,[98][99][100][101]. Notably, maternal rs10830963 (C > G) had an association with offspring birth weight [13,102].…”