&lt;i&gt;Plasmodium falciparum&lt;/i&gt; Malaria Infection Complicated by Haemophagocytic Syndrome in an Old Man

Rétornaz, F.; Seux, V.; Arnoulet, Christine; Jm, Durand; Sainty, D; Soubeyrand, J.

doi:10.1159/000041055

Cited by 8 publications

(10 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…peripheral blood, hemophagocytic evidence of marrow, abnormal results of LFTs, and hyperferritinemia were consistent with current diagnostic guidelines for hemophagocytosis [3]. Few cases of HPS have been associated with malaria, mainly due to P. falciparum [4][5][6][7]. Initially, the patient was suspected of having toxic hepatitis related to heavy drinking.…”

Section: Discussionsupporting

confidence: 74%

“…In general, HPS is probably due to inappropriate or excessive immunologic responses of T cells in association with neoplastic disease, collagen disease, or infection [6]. In HPS, high levels of IFN-g, soluble IL-2 receptor, TNF-a, IL-1, and IL-6 have been demonstrated, suggesting that elaboration of activating cytokines by T-helper cells promotes activation of macrophages in this disease [2].…”

Section: Discussionmentioning

confidence: 99%

“…In HPS, high levels of IFN-g, soluble IL-2 receptor, TNF-a, IL-1, and IL-6 have been demonstrated, suggesting that elaboration of activating cytokines by T-helper cells promotes activation of macrophages in this disease [2]. These cytokines depress the proliferation of progenitor cells, which aggravate the pancytopenia due to phagocytosis of the blood cells [6]. In this study, however, no further evaluations were conducted, including additional marrow examination, in vitro activity test for erythrophagocytosis, and cytokine studies.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Plasmodium vivax malaria complicated by hemophagocytic syndrome in an immunocompetent serviceman

Park

Choi

et al. 2003

American J Hematol

View full text Add to dashboard Cite

We describe a 23-year-old retired military officer who was immunocompetent but diagnosed with hemophagocytic syndrome (HPS) by Plasmodium vivax infection. Initially, the patient was suspected to have toxic hepatitis related to heavy drinking. But abnormal hematologic findings required a further bone marrow examination and the diagnosis of HPS was made. Antimalarial chemotherapy then brought complete remission. Plasmodium falciparum, a species causing more severe malarial infection, was listed as one of the major causes of HPS. However, P. vivax was not mentioned, and only one case was reported in the literature. In this study, we suggest that P. vivax malaria should be included in the differential diagnosis of HPS, even in an immunocompetent person.

show abstract

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Plasmodium vivax malaria complicated by hemophagocytic syndrome in an immunocompetent serviceman

Park

Choi

et al. 2003

American J Hematol

View full text Add to dashboard Cite

show abstract

“…Malarial parasite was not observed in bone marrow in our case. Even, in the previous reported 12 cases of falciparum induced HLH, only 1 case had the demonstrable parasite in bone marrow as shown in Table 2b [11][12][13][14][15][16][17][18][19][20][21][22][23][24] but still malaria was considered to be the most likely cause of HLH due to temporal relationship to the illness. In our case serum LDH levels were also elevated, which, although not included in the diagnostic criteria, but have also been found to be elevated in cases of HLH reported by other studies [14].…”

Section: Discussionmentioning

confidence: 99%

Fatal Case of Haemophagocytic Syndrome Associated With Infection of Plasmodium Falciparum

Agale¹

2018

HIJ

View full text Add to dashboard Cite

Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory condition which can occur as a primary syndrome (genetic in origin) or arise secondary to infectious, rheumatologic, malignant or metabolic disorders. HLH is characterised by hypercytokinemia and organ infiltration by phagocytozing histiocytes leading to tissue damage. This entity is often under-diagnosed, especially in adults, and specific therapy is not considered early in the disease course. We report a rare and unusual case of haemophagocytic lymphohistiocytosis (HLH) associated with infection by Plasmodium falciparum. The bone marrow aspiration and biopsy showed proliferation of histiocytes with engulfed haematopoietic cells, however patient succumbed to death before treatment for HLH could be started. Thus, this case report emphasizes the need for consideration of diagnosis of HLH in adult patients so as to provide timely diagnosis and prompt treatment to improve the clinical outcome.

show abstract

“…Also this very rare syndrome is generally seen with Plasodium falciparum but not with Plasmodium vivax per say [4][5][6][7] which forms the hallmark of this case.…”

Section: Discussionmentioning

confidence: 99%

A case of hemophagocytic syndrome as a complication of <i>Plasmodium</i> vivax malaria

Mukharjee¹,

Sagar²,

Fulara³

et al. 2013

OJCD

View full text Add to dashboard Cite

ABSTRACT. We report a case of hemophagocytic syndrome as a complication of Plasmodium vivax malaria which is a rare presentation according to the data. This patient presented with high grade fever with chills (P. vivax positive), fever however did not respond to anti-malarials. The patient continued to have high grade fever with altered sensorium and deranged liver function with pancytopenia. Since she fulfilled the criteria of (HPS), patient was put on injectable steroids and responded dramatically. Hemophagocytic syndrome is a potentially fatal syndrome and therefore high index suspicion and early treatment is the key to reduce the mortatlity.

show abstract

<i>Plasmodium falciparum</i> Malaria Infection Complicated by Haemophagocytic Syndrome in an Old Man

Cited by 8 publications

References 3 publications

Plasmodium vivax malaria complicated by hemophagocytic syndrome in an immunocompetent serviceman

Plasmodium vivax malaria complicated by hemophagocytic syndrome in an immunocompetent serviceman

Fatal Case of Haemophagocytic Syndrome Associated With Infection of Plasmodium Falciparum

A case of hemophagocytic syndrome as a complication of <i>Plasmodium</i> vivax malaria

Contact Info

Product

Resources

About

<i>Plasmodium falciparum</i> Malaria Infection Complicated by Haemophagocytic Syndrome in an Old Man

Cited by 8 publications

References 3 publications

Plasmodium vivax malaria complicated by hemophagocytic syndrome in an immunocompetent serviceman

Plasmodium vivax malaria complicated by hemophagocytic syndrome in an immunocompetent serviceman

Fatal Case of Haemophagocytic Syndrome Associated With Infection of Plasmodium Falciparum

A case of hemophagocytic syndrome as a complication of &lt;i&gt;Plasmodium&lt;/i&gt; vivax malaria

Contact Info

Product

Resources

About

A case of hemophagocytic syndrome as a complication of <i>Plasmodium</i> vivax malaria