<I>Rubus sanctus</I> protects against carbon tetrachloride-induced toxicity in rat isolated hepatocytes: isolation and characterization of its galloylated flavonoids

Abstract

In conclusion, RE protects against CCl(4)-induced toxicity in isolated rat hepatocytes.

Anti-apoptotic effects of tamarind leaves against ethanol-induced rat liver injury

“…These waste products, which contain a lot of phenolics, demonstrated antioxidant and anti‐apoptotic hepatoprotective effects in the current experiments on a rat model. These findings are in frank agreement with previous effects of polyphenols as demonstrated by our groups [20,23] and by others [24] . It has been reported that chlorogenic acid has a strong antioxidant activity, as well as catechin and epicatechin [25] .…”

The genus Rubus L.: An insight into phytochemicals and pharmacological studies of leaves from the most promising species

“…In a model of CCl 4 -induced hepatotoxicity in isolated hepatocytes, the methanol-aqueous extract of R. sanctus (100 mg/ml) showed hepatoprotective activity: it restored the levels of the antioxidant marker GSH, the enzymes lactate dehydrogenase (LDH) by 40%, alanine aminotransferase (ALAT) by 30%, and aspartate aminotransferase (ASAT) by 20% compared to the CCl 4 -treated group (Badr et al 2009). Antioxidant effects were found regarding lipid peroxidation and TBARS (thiobarbituric acid reactive substances) formation in isolated hepatocytes.…”

“…Galloyl esters of flavonols were isolated from the hydroalcoholic extract of R. sanctus leaves: Km-, Qu-, and myricetin-3-O-(6"-galloyl)-β-D-galactopyranoside (Badr et al 2009). Coumaroylhexoside derivatives of flavonols are present in Rubus leaves, including Qu and Km 3-O-(6"-O-p-coumaroyl)-glucoside (tiliroside) (69) (Pavlovic et al 2016).…”

Potentilla and Rubus medicinal plants

“…R. parvifolius extract possessed prominent hepatoprotective effects against CCl4induced hepatic injury in mice, which was at least partially ascribed to its strong antioxidant capacity (Gao et al, 2011). R. sanctus aqueous alcoholic extract contains a complicated phenolic mixture (ellagitannins, flavonoids, and caffeic acid derivatives) and protects against CCl 4induced toxicity in isolated rat hepatocytes (Badr et al, 2009). R. sanctus aqueous alcoholic extract contains a complicated phenolic mixture (ellagitannins, flavonoids, and caffeic acid derivatives) and protects against CCl 4induced toxicity in isolated rat hepatocytes (Badr et al, 2009).…”