<i>Zizyphus spina-Christi</i> Extract Protects Against Aflatoxin B1- Intitiated Hepatic Carcinogenicity

Abstract

Aflatoxins (AF), a group of closely related, extremely toxic mycotoxins, produced by Aspergillus flavus and A. parasiticus can occur as natural contaminants of foods and feeds. Aflatoxins have been shown to be hepatotoxic, carcinogenic, mutagenic, and teratogenic to different animal species. Zizyphus spina-christi L. extract was investigated for its antifungal and antimicrobial activities. The aim of the present work was to evaluate the antioxidant activity of the methanol extract of Z. spina-christi L. leaves against the oxidative stress of aflatoxin in rats. Fourty male Sprague-Dawley male rats were divided into four groups including the control group, the group fed aflatoxin-contaminated diet (3 mg /kg diet) and the groups treated with Zizyphus extract (5 mg /kg b.w) alone or in combination with AF for 15 days. Biochemical analysis reveled that treatment with AF resulted in a significant increase in ALT, AST, cholesterol, triglycerides, uric acid, TNFa, LPO, NO and CEA, whereas it decrease significantly GPX and SOD. The histopatholgical examination of the liver, kidney and testis showed sever histological changes typical to those reported for aflatoxicosis. Animals treated with Zizyphus extract alone or plus AF showed a significant improvement in all biochemical parameters and histological picture of liver, kidney and testis. It could be concluded that Zizyphus extract have a power protective role against aflatoxicosis.

Neuroprotective effect of <i>Ziziphus spina-christi</i> on brain injury induced by transient global cerebral ischemia and reperfusion in rat

“…They concluded that Z. spinachristi extract had a markedly protective effect against a flatoxicosis. It is well documented that Z. spina-christi extract is enriched in flavonoid compounds, which can reduce the production of ROS and also show good scavenging activity (Abdel-Wahhab et al (2007). These findings could explain the observed enhancement of the total anti-oxidant capacity and the reduced MDA level in rats treated with Z. spina-christi leaves extract.…”

“…The main phytochemical constituents of this plant are including phenolic, flavonoids, alkaloids and saponins (Asgarpanah and Haghighat, 2012). Abdel-Wahhab et al (2007) evaluated the anti-oxidant effect of methanolic Z. spina-christi leaf extract on the oxidative stress of aflatoxin in rats. They reported that the treatment of rats with Z. spina-christi extract significantly improved all biochemical parameters and histological profiles of liver, kidney and testis.…”

Hepatotoxicity of Pirimiphos-Methyl on Wistar Rats

“…Alteration in the architecture of the liver cells could result in the release of certain indicator enzymes in the body. The liver functional transaminases (AST and ALT) and alkaline phosphatase (ALP) enzyme activity in serum are most frequently measured for diagnosis of liver diseases particularly infective hepatitis, alcoholic cirrhosis, biliary obstruction and hepatocarcinoma [3,24]. It has been reported that the normal levels of the former liver functional enzymes activity are up to 37 IU/L for AST, 41 IU/L for ALT and 68-400IU/L for ALP in healthy individual rat sera [25,26].…”

„Azon orvosságok kezdete, melyeket a májra adnak”

“…A növényi kivonat gátolta a CYP 1A1/2 enzimet, amely részt vesz az aflatoxin-B1 bioaktiválásában. A kivonat az aflatoxin-B1 által okozott hepatocarcinogenesis és DNSkárosodás megakadályozását a fázis II enzimek, glutation-S-transzferáz és GSH-peroxidáz aktiválásával éri el [34].…”